FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979741830> ?p ?o ?g. }

• W2979741830 endingPage "5063" @default.
• W2979741830 startingPage "5063" @default.
• W2979741830 abstract "Drug resistance represents a major issue in treating breast cancer, despite the identification of novel therapeutic strategies, biomarkers, and subgroups. We have previously identified the LQB-223, 11a-N-Tosyl-5-deoxi-pterocarpan, as a promising compound in sensitizing doxorubicin-resistant breast cancer cells, with little toxicity to non-neoplastic cells. Here, we investigated the mechanisms underlying LQB-223 antitumor effects in 2D and 3D models of breast cancer. MCF-7 and MDA-MB-231 cells had migration and motility profile assessed by wound-healing and phagokinetic track motility assays, respectively. Cytotoxicity in 3D conformation was evaluated by measuring spheroid size and performing acid phosphatase and gelatin migration assays. Protein expression was analyzed by immunoblotting. Our results show that LQB-223, but not doxorubicin treatment, suppressed the migratory and motility capacity of breast cancer cells. In 3D conformation, LQB-223 remarkably decreased cell viability, as well as reduced 3D culture size and migration. Mechanistically, LQB-223-mediated anticancer effects involved decreased proteins levels of XIAP, c-IAP1, and Mcl-1 chemoresistance-related proteins, but not survivin. Survivin knockdown partially potentiated LQB-223-induced cytotoxicity. Additionally, cell treatment with LQB-223 resulted in changes in the mRNA levels of epithelial-mesenchymal transition markers, suggesting that it might modulate cell plasticity. Our data demonstrate that LQB-223 impairs 3D culture growth and migration in 2D and 3D models of breast cancer exhibiting different phenotypes." @default.
• W2979741830 created "2019-10-18" @default.
• W2979741830 creator A5013280515 @default.
• W2979741830 creator A5015983176 @default.
• W2979741830 creator A5018386252 @default.
• W2979741830 creator A5020071379 @default.
• W2979741830 creator A5022782212 @default.
• W2979741830 creator A5050933680 @default.
• W2979741830 creator A5058443506 @default.
• W2979741830 creator A5070946381 @default.
• W2979741830 creator A5086610740 @default.
• W2979741830 creator A5087213224 @default.
• W2979741830 creator A5090478209 @default.
• W2979741830 date "2019-10-12" @default.
• W2979741830 modified "2023-09-26" @default.
• W2979741830 title "The LQB-223 Compound Modulates Antiapoptotic Proteins and Impairs Breast Cancer Cell Growth and Migration" @default.
• W2979741830 cites W1662899239 @default.
• W2979741830 cites W1856175162 @default.
• W2979741830 cites W1881540319 @default.
• W2979741830 cites W1965659632 @default.
• W2979741830 cites W1981920755 @default.
• W2979741830 cites W1982288977 @default.
• W2979741830 cites W1984326475 @default.
• W2979741830 cites W2005204750 @default.
• W2979741830 cites W2005895632 @default.
• W2979741830 cites W2036959910 @default.
• W2979741830 cites W2039274123 @default.
• W2979741830 cites W2042572261 @default.
• W2979741830 cites W2044590638 @default.
• W2979741830 cites W2044702943 @default.
• W2979741830 cites W2047866696 @default.
• W2979741830 cites W2048893832 @default.
• W2979741830 cites W2065392301 @default.
• W2979741830 cites W2091238429 @default.
• W2979741830 cites W2094454542 @default.
• W2979741830 cites W2097255042 @default.
• W2979741830 cites W2099540110 @default.
• W2979741830 cites W2104176186 @default.
• W2979741830 cites W2165316896 @default.
• W2979741830 cites W2178157469 @default.
• W2979741830 cites W2259802687 @default.
• W2979741830 cites W2359219670 @default.
• W2979741830 cites W2461857357 @default.
• W2979741830 cites W2510822586 @default.
• W2979741830 cites W2515795587 @default.
• W2979741830 cites W2529945511 @default.
• W2979741830 cites W2549441121 @default.
• W2979741830 cites W2560357342 @default.
• W2979741830 cites W2567218831 @default.
• W2979741830 cites W2569617947 @default.
• W2979741830 cites W2572077158 @default.
• W2979741830 cites W2585573922 @default.
• W2979741830 cites W2586363758 @default.
• W2979741830 cites W2591810315 @default.
• W2979741830 cites W2596851559 @default.
• W2979741830 cites W2601260305 @default.
• W2979741830 cites W2621577071 @default.
• W2979741830 cites W2736563004 @default.
• W2979741830 cites W2739546484 @default.
• W2979741830 cites W2755778068 @default.
• W2979741830 cites W2762328399 @default.
• W2979741830 cites W2791738263 @default.
• W2979741830 cites W2793670714 @default.
• W2979741830 cites W2802441329 @default.
• W2979741830 cites W2809026310 @default.
• W2979741830 cites W2810356027 @default.
• W2979741830 cites W2882982837 @default.
• W2979741830 cites W2883808667 @default.
• W2979741830 cites W2886795971 @default.
• W2979741830 cites W2898365111 @default.
• W2979741830 cites W2901391456 @default.
• W2979741830 cites W2907477825 @default.
• W2979741830 cites W2914792039 @default.
• W2979741830 cites W2924352987 @default.
• W2979741830 cites W2950973328 @default.
• W2979741830 cites W2966353244 @default.
• W2979741830 cites W2989985966 @default.
• W2979741830 doi "https://doi.org/10.3390/ijms20205063" @default.
• W2979741830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6834317" @default.
• W2979741830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31614718" @default.
• W2979741830 hasPublicationYear "2019" @default.
• W2979741830 type Work @default.
• W2979741830 sameAs 2979741830 @default.
• W2979741830 citedByCount "1" @default.
• W2979741830 countsByYear W29797418302022 @default.
• W2979741830 crossrefType "journal-article" @default.
• W2979741830 hasAuthorship W2979741830A5013280515 @default.
• W2979741830 hasAuthorship W2979741830A5015983176 @default.
• W2979741830 hasAuthorship W2979741830A5018386252 @default.
• W2979741830 hasAuthorship W2979741830A5020071379 @default.
• W2979741830 hasAuthorship W2979741830A5022782212 @default.
• W2979741830 hasAuthorship W2979741830A5050933680 @default.
• W2979741830 hasAuthorship W2979741830A5058443506 @default.
• W2979741830 hasAuthorship W2979741830A5070946381 @default.
• W2979741830 hasAuthorship W2979741830A5086610740 @default.
• W2979741830 hasAuthorship W2979741830A5087213224 @default.
• W2979741830 hasAuthorship W2979741830A5090478209 @default.
• W2979741830 hasBestOaLocation W29797418301 @default.

• next