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- W2979758103 abstract "Abstract Background ALK (anaplastic lymphoma kinase) activation in cancer was discovered in anaplastic large-cell non-Hodgkin’s lymphoma, followed by non-small cell lung cancer. Since then, several human cancers have reported to present ALK alterations, such as translocation, overexpression and mutation. ALK-tyrosine kinase inhibitors are reported to be effective in some of these cancers. Methods TACKLE (NCCH1712/MK003) is a phase II study designed to evaluate efficacy and safety of alectinib in patients with ALK-positive advanced rare cancer. This study is conducted as part of the MASTER KEY project, which is a basket/umbrella trial including a registry study for rare cancers (UMI27552). ALK-positive was defined as follow, 1) translocation, 2) activating mutation, 3) overexpression. Rare cancer was defined as annual incidence Clinical Trial Information JMA-IIA00364" @default.
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- W2979758103 date "2019-10-01" @default.
- W2979758103 modified "2023-10-12" @default.
- W2979758103 title "TACKLE: A phase II study of alectinib in patients with unresectable rare cancer harboring ALK alterations (NCCH1712)" @default.
- W2979758103 doi "https://doi.org/10.1093/annonc/mdz343.089" @default.
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