FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979766553> ?p ?o ?g. }

• W2979766553 abstract "Tacrolimus is one of the most used and effective immunosuppressive agents currently available in the clinic; however, its use is limited by nephrotoxicity, which is the main secondary effect of this drug. The mechanisms underlying tacrolimus‑induced nephrotoxicity remain unknown. The present study aimed to investigate the mechanism underlying tacrolimus‑induced nephrotoxicity and to identify novel potential targets. Masson staining, Sirius red staining and periodic acid‑silver methenamine staining were used to observe kidney pathological changes. Immunohistochemical and immunofluorescent analyses were performed to examine the expression levels of vimentin, E‑cadherin and α‑smooth muscle actin (α‑SMA). Transcriptomics and bioinformatics analyses were performed to investigate the nephrotoxicity mechanism induced by tacrolimus using RNA‑sequencing, differentially expressed genes identification and annotation, and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. The present results demonstrated that compared with the normal control group, the tacrolimus nephrotoxicity group exhibited severe renal fibrosis (P<0.05), upregulated vimentin (P<0.01), downregulated E‑cadherin (P<0.05) and upregulated α‑SMA (P<0.01). Transcriptomics and bioinformatics analyses identified the pathway ‘cytokine‑cytokine receptor interaction’ as the most significantly enriched (P<0.05). Moreover, KEGG pathway enrichment analysis identified that tacrolimus increased the expression levels of chemokine (C‑X‑C) motif ligand (CXCL)1, CXCL2 and CXCL3 and the chemokine receptor C‑X‑C chemokine receptor type 2 (CXCR2). Collectively, the present study suggested that tacrolimus increases the level of chemokine receptor CXCR2 to promote renal fibrosis progression, which is one of the potential mechanisms underlying tacrolimus‑induced nephrotoxicity." @default.
• W2979766553 created "2019-10-18" @default.
• W2979766553 creator A5034205421 @default.
• W2979766553 creator A5034654778 @default.
• W2979766553 creator A5067371995 @default.
• W2979766553 creator A5080434445 @default.
• W2979766553 creator A5087787378 @default.
• W2979766553 date "2019-10-10" @default.
• W2979766553 modified "2023-09-27" @default.
• W2979766553 title "Tacrolimus increases the expression level of the chemokine receptor CXCR2 to promote renal fibrosis progression" @default.
• W2979766553 cites W1493455024 @default.
• W2979766553 cites W1503743739 @default.
• W2979766553 cites W1563789749 @default.
• W2979766553 cites W1969443066 @default.
• W2979766553 cites W1974595846 @default.
• W2979766553 cites W1984068087 @default.
• W2979766553 cites W1984768559 @default.
• W2979766553 cites W1984947099 @default.
• W2979766553 cites W1987997716 @default.
• W2979766553 cites W1996938687 @default.
• W2979766553 cites W1997062945 @default.
• W2979766553 cites W2000576945 @default.
• W2979766553 cites W2017618070 @default.
• W2979766553 cites W2027774666 @default.
• W2979766553 cites W2028641895 @default.
• W2979766553 cites W2031400172 @default.
• W2979766553 cites W2044601245 @default.
• W2979766553 cites W2045245752 @default.
• W2979766553 cites W2063338463 @default.
• W2979766553 cites W2065097998 @default.
• W2979766553 cites W2066243575 @default.
• W2979766553 cites W2066362593 @default.
• W2979766553 cites W2068650301 @default.
• W2979766553 cites W2079880211 @default.
• W2979766553 cites W2086840464 @default.
• W2979766553 cites W2087775788 @default.
• W2979766553 cites W2090981374 @default.
• W2979766553 cites W2091048867 @default.
• W2979766553 cites W2117761398 @default.
• W2979766553 cites W2127913202 @default.
• W2979766553 cites W2128503092 @default.
• W2979766553 cites W2132610899 @default.
• W2979766553 cites W2140688313 @default.
• W2979766553 cites W2159482845 @default.
• W2979766553 cites W2225842963 @default.
• W2979766553 cites W2323251827 @default.
• W2979766553 cites W2334390934 @default.
• W2979766553 cites W2344339846 @default.
• W2979766553 cites W2400991174 @default.
• W2979766553 cites W2512194105 @default.
• W2979766553 cites W2773893742 @default.
• W2979766553 cites W2782138706 @default.
• W2979766553 cites W2791554788 @default.
• W2979766553 cites W2804822518 @default.
• W2979766553 cites W2898974435 @default.
• W2979766553 cites W2903515788 @default.
• W2979766553 cites W2911020049 @default.
• W2979766553 cites W2911814706 @default.
• W2979766553 cites W2920935218 @default.
• W2979766553 cites W2925694497 @default.
• W2979766553 cites W2942380144 @default.
• W2979766553 cites W2946006988 @default.
• W2979766553 cites W2947809282 @default.
• W2979766553 cites W2954892726 @default.
• W2979766553 cites W2965676704 @default.
• W2979766553 cites W2967069704 @default.
• W2979766553 cites W2969680240 @default.
• W2979766553 cites W405180396 @default.
• W2979766553 cites W4294216483 @default.
• W2979766553 doi "https://doi.org/10.3892/ijmm.2019.4368" @default.
• W2979766553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6844638" @default.
• W2979766553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31638188" @default.
• W2979766553 hasPublicationYear "2019" @default.
• W2979766553 type Work @default.
• W2979766553 sameAs 2979766553 @default.
• W2979766553 citedByCount "8" @default.
• W2979766553 countsByYear W29797665532021 @default.
• W2979766553 countsByYear W29797665532022 @default.
• W2979766553 countsByYear W29797665532023 @default.
• W2979766553 crossrefType "journal-article" @default.
• W2979766553 hasAuthorship W2979766553A5034205421 @default.
• W2979766553 hasAuthorship W2979766553A5034654778 @default.
• W2979766553 hasAuthorship W2979766553A5067371995 @default.
• W2979766553 hasAuthorship W2979766553A5080434445 @default.
• W2979766553 hasAuthorship W2979766553A5087787378 @default.
• W2979766553 hasBestOaLocation W29797665531 @default.
• W2979766553 hasConcept C126189478 @default.
• W2979766553 hasConcept C126322002 @default.
• W2979766553 hasConcept C12823836 @default.
• W2979766553 hasConcept C13373296 @default.
• W2979766553 hasConcept C134018914 @default.
• W2979766553 hasConcept C203014093 @default.
• W2979766553 hasConcept C2776914184 @default.
• W2979766553 hasConcept C2780091579 @default.
• W2979766553 hasConcept C2909675724 @default.
• W2979766553 hasConcept C2911091166 @default.
• W2979766553 hasConcept C502942594 @default.
• W2979766553 hasConcept C71924100 @default.
• W2979766553 hasConcept C86803240 @default.
• W2979766553 hasConcept C98274493 @default.

• next