FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979779566> ?p ?o ?g. }

• W2979779566 abstract "Aberrant expression of the epidermal growth factor receptor (EGFR) plays vital roles in tumor development and progression. In the present study, ultraviolet irradiation induced the upregulation of EGFR in skin‑derived keratinocytes, which may contribute to the development of cutaneous squamous cell carcinoma (CSCC). This was supported by the high expression of EGFR in CSCC clinical samples. Treating A431 CSCC cells with gefitinib, a tyrosine kinase inhibitor, activated the intrinsic mitochondrial apoptotic pathway while inducing protective autophagy. Combined application of chloroquine with gefitinib enhanced the treatment efficacy of gefitinib against CSCC by inhibiting autophagic flux. These findings demonstrated that autophagy inhibition may be an effective strategy for enhancing the sensitivity of EGFR‑expressing cells to tyrosine kinase inhibitor treatment. Manipulating pro‑survival autophagy by the combined application of chloroquine with gefitinib is a promising approach for improving the efficacy of EGFR inhibitors in cancer treatment. This may contribute to novel EGFR‑targeted therapeutic strategies in the near future." @default.
• W2979779566 created "2019-10-18" @default.
• W2979779566 creator A5009417825 @default.
• W2979779566 creator A5018341654 @default.
• W2979779566 creator A5071985886 @default.
• W2979779566 creator A5091777106 @default.
• W2979779566 date "2019-10-09" @default.
• W2979779566 modified "2023-09-29" @default.
• W2979779566 title "Chloroquine promotes gefitinib‑induced apoptosis by inhibiting protective autophagy in cutaneous squamous cell carcinoma" @default.
• W2979779566 cites W1523693806 @default.
• W2979779566 cites W1529230314 @default.
• W2979779566 cites W1837617056 @default.
• W2979779566 cites W1998613363 @default.
• W2979779566 cites W2003984225 @default.
• W2979779566 cites W2024902613 @default.
• W2979779566 cites W2026198376 @default.
• W2979779566 cites W2030570585 @default.
• W2979779566 cites W2035748563 @default.
• W2979779566 cites W2043696829 @default.
• W2979779566 cites W2045122835 @default.
• W2979779566 cites W2073557222 @default.
• W2979779566 cites W2093034235 @default.
• W2979779566 cites W2107277218 @default.
• W2979779566 cites W2131757723 @default.
• W2979779566 cites W2133000461 @default.
• W2979779566 cites W2135514753 @default.
• W2979779566 cites W2142845200 @default.
• W2979779566 cites W2157824687 @default.
• W2979779566 cites W2164778558 @default.
• W2979779566 cites W2165310182 @default.
• W2979779566 cites W2168391786 @default.
• W2979779566 cites W2312266417 @default.
• W2979779566 cites W2551865970 @default.
• W2979779566 cites W2740002839 @default.
• W2979779566 cites W2802700656 @default.
• W2979779566 cites W1964184380 @default.
• W2979779566 doi "https://doi.org/10.3892/mmr.2019.10734" @default.
• W2979779566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6854599" @default.
• W2979779566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31638204" @default.
• W2979779566 hasPublicationYear "2019" @default.
• W2979779566 type Work @default.
• W2979779566 sameAs 2979779566 @default.
• W2979779566 citedByCount "5" @default.
• W2979779566 countsByYear W29797795662020 @default.
• W2979779566 countsByYear W29797795662021 @default.
• W2979779566 countsByYear W29797795662022 @default.
• W2979779566 crossrefType "journal-article" @default.
• W2979779566 hasAuthorship W2979779566A5009417825 @default.
• W2979779566 hasAuthorship W2979779566A5018341654 @default.
• W2979779566 hasAuthorship W2979779566A5071985886 @default.
• W2979779566 hasAuthorship W2979779566A5091777106 @default.
• W2979779566 hasBestOaLocation W29797795661 @default.
• W2979779566 hasConcept C104317684 @default.
• W2979779566 hasConcept C121608353 @default.
• W2979779566 hasConcept C126322002 @default.
• W2979779566 hasConcept C127561419 @default.
• W2979779566 hasConcept C190283241 @default.
• W2979779566 hasConcept C203522944 @default.
• W2979779566 hasConcept C2778820342 @default.
• W2979779566 hasConcept C2779438470 @default.
• W2979779566 hasConcept C2780580887 @default.
• W2979779566 hasConcept C2781018059 @default.
• W2979779566 hasConcept C29537977 @default.
• W2979779566 hasConcept C42362537 @default.
• W2979779566 hasConcept C502942594 @default.
• W2979779566 hasConcept C55493867 @default.
• W2979779566 hasConcept C62478195 @default.
• W2979779566 hasConcept C71924100 @default.
• W2979779566 hasConcept C86803240 @default.
• W2979779566 hasConcept C95444343 @default.
• W2979779566 hasConceptScore W2979779566C104317684 @default.
• W2979779566 hasConceptScore W2979779566C121608353 @default.
• W2979779566 hasConceptScore W2979779566C126322002 @default.
• W2979779566 hasConceptScore W2979779566C127561419 @default.
• W2979779566 hasConceptScore W2979779566C190283241 @default.
• W2979779566 hasConceptScore W2979779566C203522944 @default.
• W2979779566 hasConceptScore W2979779566C2778820342 @default.
• W2979779566 hasConceptScore W2979779566C2779438470 @default.
• W2979779566 hasConceptScore W2979779566C2780580887 @default.
• W2979779566 hasConceptScore W2979779566C2781018059 @default.
• W2979779566 hasConceptScore W2979779566C29537977 @default.
• W2979779566 hasConceptScore W2979779566C42362537 @default.
• W2979779566 hasConceptScore W2979779566C502942594 @default.
• W2979779566 hasConceptScore W2979779566C55493867 @default.
• W2979779566 hasConceptScore W2979779566C62478195 @default.
• W2979779566 hasConceptScore W2979779566C71924100 @default.
• W2979779566 hasConceptScore W2979779566C86803240 @default.
• W2979779566 hasConceptScore W2979779566C95444343 @default.
• W2979779566 hasLocation W29797795661 @default.
• W2979779566 hasLocation W29797795662 @default.
• W2979779566 hasLocation W29797795663 @default.
• W2979779566 hasLocation W29797795664 @default.
• W2979779566 hasOpenAccess W2979779566 @default.
• W2979779566 hasPrimaryLocation W29797795661 @default.
• W2979779566 hasRelatedWork W1482573140 @default.
• W2979779566 hasRelatedWork W1855687750 @default.
• W2979779566 hasRelatedWork W2011806260 @default.
• W2979779566 hasRelatedWork W2035549030 @default.
• W2979779566 hasRelatedWork W2057074963 @default.
• W2979779566 hasRelatedWork W2085384252 @default.

• next