Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979782890> ?p ?o ?g. }
- W2979782890 abstract "Abstract Identifying the mechanisms underlying cognitive development in early life is a critical objective. The expression of insulin‐like growth factor binding protein 2 (IGFBP2) in the hippocampus increases during neonatal development and is associated with learning and memory, but a causal connection has not been established. Here, it is reported that neurons and astrocytes expressing IGFBP2 are distributed throughout the hippocampus. IGFBP2 enhances excitatory inputs onto CA1 pyramidal neurons, facilitating intrinsic excitability and spike transmission, and regulates plasticity at excitatory synapses in a cell‐type specific manner. It facilitates long‐term potentiation (LTP) by enhancing N‐methyl‐ d ‐aspartate (NMDA) receptor‐dependent excitatory postsynaptic current (EPSC), and enhances neurite proliferation and elongation. Knockout of igfbp2 reduces the numbers of pyramidal cells and interneurons, impairs LTP and cognitive performance, and reduces tonic excitation of pyramidal neurons that are all rescued by IGFBP2. The results provide insight into the requirement for IGFBP2 in cognition in early life." @default.
- W2979782890 created "2019-10-18" @default.
- W2979782890 creator A5006977688 @default.
- W2979782890 creator A5009020573 @default.
- W2979782890 creator A5019034734 @default.
- W2979782890 creator A5019399811 @default.
- W2979782890 creator A5031197115 @default.
- W2979782890 creator A5036027640 @default.
- W2979782890 creator A5045823901 @default.
- W2979782890 creator A5047874096 @default.
- W2979782890 creator A5048241447 @default.
- W2979782890 creator A5048325535 @default.
- W2979782890 creator A5051444931 @default.
- W2979782890 creator A5064842058 @default.
- W2979782890 creator A5070671062 @default.
- W2979782890 creator A5082041657 @default.
- W2979782890 creator A5082398206 @default.
- W2979782890 creator A5087918540 @default.
- W2979782890 date "2019-10-14" @default.
- W2979782890 modified "2023-10-14" @default.
- W2979782890 title "IGFBP2 Plays an Essential Role in Cognitive Development during Early Life" @default.
- W2979782890 cites W1521954724 @default.
- W2979782890 cites W1989924763 @default.
- W2979782890 cites W2008069212 @default.
- W2979782890 cites W2010110624 @default.
- W2979782890 cites W2020799083 @default.
- W2979782890 cites W2020914828 @default.
- W2979782890 cites W2022060657 @default.
- W2979782890 cites W2023397398 @default.
- W2979782890 cites W2039743252 @default.
- W2979782890 cites W2059743066 @default.
- W2979782890 cites W2067443877 @default.
- W2979782890 cites W2077208091 @default.
- W2979782890 cites W2094807062 @default.
- W2979782890 cites W2096681544 @default.
- W2979782890 cites W2106274713 @default.
- W2979782890 cites W2109618496 @default.
- W2979782890 cites W2117897492 @default.
- W2979782890 cites W2118775306 @default.
- W2979782890 cites W2119184935 @default.
- W2979782890 cites W2140735962 @default.
- W2979782890 cites W2156222687 @default.
- W2979782890 cites W2172078136 @default.
- W2979782890 cites W2261030667 @default.
- W2979782890 cites W2272398100 @default.
- W2979782890 cites W2287764147 @default.
- W2979782890 cites W2293311540 @default.
- W2979782890 cites W2594797417 @default.
- W2979782890 cites W2600293296 @default.
- W2979782890 cites W2613711356 @default.
- W2979782890 cites W2623090940 @default.
- W2979782890 cites W2746575140 @default.
- W2979782890 cites W2791142331 @default.
- W2979782890 cites W2796344372 @default.
- W2979782890 cites W2797389850 @default.
- W2979782890 cites W2808556497 @default.
- W2979782890 cites W2883065428 @default.
- W2979782890 cites W2889283495 @default.
- W2979782890 cites W2912841818 @default.
- W2979782890 doi "https://doi.org/10.1002/advs.201901152" @default.
- W2979782890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6891907" @default.
- W2979782890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31832311" @default.
- W2979782890 hasPublicationYear "2019" @default.
- W2979782890 type Work @default.
- W2979782890 sameAs 2979782890 @default.
- W2979782890 citedByCount "14" @default.
- W2979782890 countsByYear W29797828902019 @default.
- W2979782890 countsByYear W29797828902021 @default.
- W2979782890 countsByYear W29797828902022 @default.
- W2979782890 countsByYear W29797828902023 @default.
- W2979782890 crossrefType "journal-article" @default.
- W2979782890 hasAuthorship W2979782890A5006977688 @default.
- W2979782890 hasAuthorship W2979782890A5009020573 @default.
- W2979782890 hasAuthorship W2979782890A5019034734 @default.
- W2979782890 hasAuthorship W2979782890A5019399811 @default.
- W2979782890 hasAuthorship W2979782890A5031197115 @default.
- W2979782890 hasAuthorship W2979782890A5036027640 @default.
- W2979782890 hasAuthorship W2979782890A5045823901 @default.
- W2979782890 hasAuthorship W2979782890A5047874096 @default.
- W2979782890 hasAuthorship W2979782890A5048241447 @default.
- W2979782890 hasAuthorship W2979782890A5048325535 @default.
- W2979782890 hasAuthorship W2979782890A5051444931 @default.
- W2979782890 hasAuthorship W2979782890A5064842058 @default.
- W2979782890 hasAuthorship W2979782890A5070671062 @default.
- W2979782890 hasAuthorship W2979782890A5082041657 @default.
- W2979782890 hasAuthorship W2979782890A5082398206 @default.
- W2979782890 hasAuthorship W2979782890A5087918540 @default.
- W2979782890 hasBestOaLocation W29797828901 @default.
- W2979782890 hasConcept C112592302 @default.
- W2979782890 hasConcept C169760540 @default.
- W2979782890 hasConcept C170493617 @default.
- W2979782890 hasConcept C17077164 @default.
- W2979782890 hasConcept C197341189 @default.
- W2979782890 hasConcept C200170125 @default.
- W2979782890 hasConcept C25274449 @default.
- W2979782890 hasConcept C2781161787 @default.
- W2979782890 hasConcept C55493867 @default.
- W2979782890 hasConcept C67018056 @default.
- W2979782890 hasConcept C86803240 @default.
- W2979782890 hasConcept C98229152 @default.