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- W2979820907 endingPage "4159" @default.
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- W2979820907 abstract "Purpose: The purpose of this study was to examine the effect of multiple blast exposures and blast preconditioning on the structure and function of retinal ganglion cells (RGCs), to identify molecular pathways that contribute to RGC loss, and to evaluate the role of kynurenine-3-monooxygenase (KMO) inhibition on RGC structure and function. Methods: Mice were subjected to sham blast injury, one single blast injury, or three blast injuries separated by either 1 hour or 1 week, using a blast intensity of 20 PSI. To examine the effect of blast preconditioning, mice were subjected to sham blast injury, one single 20-PSI injury, or three blast injuries separated by 1 week (5 PSI, 5 PSI, 20 PSI and 5 PSI, 5 PSI, 5 PSI). RGC structure was analyzed by optical coherence tomography (OCT) and function was analyzed by the pattern electroretinogram (PERG). BRN3A-positive cells were quantified to determine RGC density. RNA-seq analysis was used to identify transcriptional changes between groups. Results: Analysis of mice with multiple blast exposures of 20 PSI revealed no significant differences compared to one 20-pounds per square inch (PSI) exposure using OCT, PERG, or BRN3A cell counts. Analysis of mice exposed to two preconditioning 5-PSI blasts prior to one 20-PSI blast showed preservation of RGC structure and function. RNA-seq analysis of the retina identified multiple transcriptomic changes between conditions. Pharmacologic inhibition of KMO preserved RGC responses compared to vehicle-treated mice. Conclusions: Preconditioning protects RGC from blast injury. Protective effects appear to involve changes in KMO activity, whose inhibition is also protective." @default.
- W2979820907 created "2019-10-18" @default.
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- W2979820907 date "2019-10-09" @default.
- W2979820907 modified "2023-10-15" @default.
- W2979820907 title "Blast Preconditioning Protects Retinal Ganglion Cells and Reveals Targets for Prevention of Neurodegeneration Following Blast-Mediated Traumatic Brian Injury" @default.
- W2979820907 cites W1200068469 @default.
- W2979820907 cites W1484554870 @default.
- W2979820907 cites W1520386485 @default.
- W2979820907 cites W1573025925 @default.
- W2979820907 cites W1862407261 @default.
- W2979820907 cites W1867264094 @default.
- W2979820907 cites W1882019559 @default.
- W2979820907 cites W1888971219 @default.
- W2979820907 cites W1965909793 @default.
- W2979820907 cites W1972653515 @default.
- W2979820907 cites W1973404077 @default.
- W2979820907 cites W1974574067 @default.
- W2979820907 cites W1979434326 @default.
- W2979820907 cites W1983733996 @default.
- W2979820907 cites W1984800913 @default.
- W2979820907 cites W1985336514 @default.
- W2979820907 cites W1989299264 @default.
- W2979820907 cites W1990286385 @default.
- W2979820907 cites W1993120818 @default.
- W2979820907 cites W1993871250 @default.
- W2979820907 cites W1999226287 @default.
- W2979820907 cites W1999987205 @default.
- W2979820907 cites W2000182546 @default.
- W2979820907 cites W2000984866 @default.
- W2979820907 cites W2003719026 @default.
- W2979820907 cites W2010703431 @default.
- W2979820907 cites W2011845342 @default.
- W2979820907 cites W2011949052 @default.
- W2979820907 cites W2013254213 @default.
- W2979820907 cites W2022349991 @default.
- W2979820907 cites W2030938312 @default.
- W2979820907 cites W2041659756 @default.
- W2979820907 cites W2058042345 @default.
- W2979820907 cites W2064187676 @default.
- W2979820907 cites W2088637934 @default.
- W2979820907 cites W2093227833 @default.
- W2979820907 cites W2100559561 @default.
- W2979820907 cites W2116016048 @default.
- W2979820907 cites W2136305574 @default.
- W2979820907 cites W2137938185 @default.
- W2979820907 cites W2138207763 @default.
- W2979820907 cites W2141385001 @default.
- W2979820907 cites W2142086230 @default.
- W2979820907 cites W2144537780 @default.
- W2979820907 cites W2145209567 @default.
- W2979820907 cites W2152239989 @default.
- W2979820907 cites W2153235672 @default.
- W2979820907 cites W2157804149 @default.
- W2979820907 cites W2169456326 @default.
- W2979820907 cites W2173210998 @default.
- W2979820907 cites W2235097232 @default.
- W2979820907 cites W2252544267 @default.
- W2979820907 cites W2258586380 @default.
- W2979820907 cites W2303092219 @default.
- W2979820907 cites W2306606219 @default.
- W2979820907 cites W2319602356 @default.
- W2979820907 cites W2322581582 @default.
- W2979820907 cites W2329270408 @default.
- W2979820907 cites W2330807792 @default.
- W2979820907 cites W2341140029 @default.
- W2979820907 cites W2377661981 @default.
- W2979820907 cites W2402602414 @default.
- W2979820907 cites W2416291464 @default.
- W2979820907 cites W2427040778 @default.
- W2979820907 cites W2503817556 @default.
- W2979820907 cites W2507454459 @default.
- W2979820907 cites W2508920792 @default.
- W2979820907 cites W2520018422 @default.
- W2979820907 cites W2530332002 @default.
- W2979820907 cites W2548833686 @default.
- W2979820907 cites W2559466477 @default.
- W2979820907 cites W2566567183 @default.
- W2979820907 cites W2578837025 @default.
- W2979820907 cites W2595951543 @default.
- W2979820907 cites W2625130810 @default.
- W2979820907 cites W2740619210 @default.
- W2979820907 cites W2783968777 @default.
- W2979820907 cites W2785262897 @default.
- W2979820907 cites W2792552392 @default.
- W2979820907 cites W2792580789 @default.
- W2979820907 cites W2794763796 @default.