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• W2979822502 abstract "The study evaluated whether it is psychomotor speed or higher-order cognitive processing which is primarily affected by antiepileptic drug (AED) treatment in epilepsy and whether computerized testing versus paper-pencil testing of executive functions is more sensitive. In this retrospective observational study, 55 patients with epilepsy underwent NeuroCog FXⓇ, a computerized battery assessing psychomotor speed/alertness and cognitive processing via 8 tasks, and EpiTrackⓇ, a paper-pencil screening of executive functions and working memory based on 6 subtests. Test performance was related to the number of drugs and the Defined Daily Dose and the presence/absence of AEDs with known adverse psychotropic effects. EpiTrackⓇ performance correlated with cognitive processing of the NeuroCog FXⓇ but not with psychomotor speed/alertness. Significant correlations with drug load were mainly yielded for EpiTrackⓇ (number of AEDs: r = -0.551, total DDD: r = -0.452) and cognitive processing (number of AEDs: r = -0.433, total DDD: r = -0.415). Psychomotor speed/alertness was less related to drug load (number of AEDs: r = -0.285, total DDD: r = -0.232). Statistical control for psychomotor speed/alertness hardly changed the correlations of EpiTrackⓇ or cognitive processing with drug load indices. AEDs with known adverse profiles negatively affected EpiTrackⓇ and the cognitive processing but not the psychomotor speed/alertness domain of the computerized test. The results demonstrate that it is less basal psychomotor speed than higher-order cognitive processing which is negatively affected by antiepileptic pharmacotherapy. The results question the value of (computer-)tests with a major emphasis on psychomotor speed and alertness for cognitive drug monitoring." @default.
• W2979822502 created "2019-10-18" @default.
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• W2979822502 date "2019-11-01" @default.
• W2979822502 modified "2023-09-24" @default.
• W2979822502 title "Is the computerized assessment of psychomotor speed more sensitive to cognitive effects of antiepileptic pharmacotherapy than tests with a focus on higher-order cognitive processing? Implications for the choice of sensitive test parameters" @default.
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• W2979822502 doi "https://doi.org/10.1016/j.euroneuro.2019.09.010" @default.
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