Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979840500> ?p ?o ?g. }
- W2979840500 endingPage "5035" @default.
- W2979840500 startingPage "5035" @default.
- W2979840500 abstract "Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by symmetric polyarthritis with swelling and pain at synovial joints. In RA patients, delayed neutrophil apoptosis amplifies the inflammatory response and massively released neutrophil extracellular traps (NETs) induce tissue damage and provide self-antigens. Andrographolide (AD) is the major active labdane diterpenoid derived from Andrographis paniculata, which has multiple pharmacological effects, including hepatoprotection, anti-angiogenesis, anti-thrombosis, and anti-inflammation. In the present study, we investigated the effect of AD on an adjuvant-induced arthritis (AA) murine model of RA and found that AD alleviated murine arthritis by reducing neutrophil infiltration and NETosis in the ankle joints and relieved the systematic inflammation. In vitro experiments showed that AD accelerated the apoptosis of lipopolysaccharide-activated neutrophils and inhibited autophagy-dependent extracellular traps formation of neutrophils. These findings suggest that AD has considerable potential for RA therapy." @default.
- W2979840500 created "2019-10-18" @default.
- W2979840500 creator A5012843798 @default.
- W2979840500 creator A5033240983 @default.
- W2979840500 creator A5036478960 @default.
- W2979840500 creator A5045470240 @default.
- W2979840500 creator A5083729859 @default.
- W2979840500 creator A5085548947 @default.
- W2979840500 creator A5088890150 @default.
- W2979840500 creator A5091216081 @default.
- W2979840500 date "2019-10-11" @default.
- W2979840500 modified "2023-10-14" @default.
- W2979840500 title "Andrographolide Ameliorates Rheumatoid Arthritis by Regulating the Apoptosis–NETosis Balance of Neutrophils" @default.
- W2979840500 cites W1551051666 @default.
- W2979840500 cites W1614500582 @default.
- W2979840500 cites W1983075934 @default.
- W2979840500 cites W1983929025 @default.
- W2979840500 cites W1986072506 @default.
- W2979840500 cites W1990092707 @default.
- W2979840500 cites W1998795233 @default.
- W2979840500 cites W1998885858 @default.
- W2979840500 cites W2008708488 @default.
- W2979840500 cites W2022675211 @default.
- W2979840500 cites W2023976647 @default.
- W2979840500 cites W2033753616 @default.
- W2979840500 cites W2047064554 @default.
- W2979840500 cites W2056686776 @default.
- W2979840500 cites W2062770015 @default.
- W2979840500 cites W2069302785 @default.
- W2979840500 cites W2070446195 @default.
- W2979840500 cites W2073666097 @default.
- W2979840500 cites W2076794463 @default.
- W2979840500 cites W2088455943 @default.
- W2979840500 cites W2091512988 @default.
- W2979840500 cites W2104294732 @default.
- W2979840500 cites W2104934425 @default.
- W2979840500 cites W2110826367 @default.
- W2979840500 cites W2127868048 @default.
- W2979840500 cites W2135510881 @default.
- W2979840500 cites W2138526118 @default.
- W2979840500 cites W2139719760 @default.
- W2979840500 cites W2140965629 @default.
- W2979840500 cites W2141522272 @default.
- W2979840500 cites W2142633654 @default.
- W2979840500 cites W2150952126 @default.
- W2979840500 cites W2153434457 @default.
- W2979840500 cites W2165578318 @default.
- W2979840500 cites W2168851595 @default.
- W2979840500 cites W2185829573 @default.
- W2979840500 cites W2270670296 @default.
- W2979840500 cites W2320328374 @default.
- W2979840500 cites W2523524440 @default.
- W2979840500 cites W2533494998 @default.
- W2979840500 cites W2553173693 @default.
- W2979840500 cites W2560882502 @default.
- W2979840500 cites W2586749826 @default.
- W2979840500 cites W2588492589 @default.
- W2979840500 cites W2600443448 @default.
- W2979840500 cites W2609222984 @default.
- W2979840500 cites W2623852148 @default.
- W2979840500 cites W2737772836 @default.
- W2979840500 cites W2752796394 @default.
- W2979840500 cites W2762816177 @default.
- W2979840500 cites W2774231884 @default.
- W2979840500 cites W2890156259 @default.
- W2979840500 cites W2890608919 @default.
- W2979840500 cites W2898283871 @default.
- W2979840500 cites W2902102863 @default.
- W2979840500 cites W2903033410 @default.
- W2979840500 cites W2911027500 @default.
- W2979840500 cites W2914524806 @default.
- W2979840500 cites W2915717782 @default.
- W2979840500 cites W4211054359 @default.
- W2979840500 cites W4211111012 @default.
- W2979840500 cites W67411145 @default.
- W2979840500 doi "https://doi.org/10.3390/ijms20205035" @default.
- W2979840500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6834122" @default.
- W2979840500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31614480" @default.
- W2979840500 hasPublicationYear "2019" @default.
- W2979840500 type Work @default.
- W2979840500 sameAs 2979840500 @default.
- W2979840500 citedByCount "35" @default.
- W2979840500 countsByYear W29798405002020 @default.
- W2979840500 countsByYear W29798405002021 @default.
- W2979840500 countsByYear W29798405002022 @default.
- W2979840500 countsByYear W29798405002023 @default.
- W2979840500 crossrefType "journal-article" @default.
- W2979840500 hasAuthorship W2979840500A5012843798 @default.
- W2979840500 hasAuthorship W2979840500A5033240983 @default.
- W2979840500 hasAuthorship W2979840500A5036478960 @default.
- W2979840500 hasAuthorship W2979840500A5045470240 @default.
- W2979840500 hasAuthorship W2979840500A5083729859 @default.
- W2979840500 hasAuthorship W2979840500A5085548947 @default.
- W2979840500 hasAuthorship W2979840500A5088890150 @default.
- W2979840500 hasAuthorship W2979840500A5091216081 @default.
- W2979840500 hasBestOaLocation W29798405001 @default.
- W2979840500 hasConcept C134897094 @default.
- W2979840500 hasConcept C142724271 @default.