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• W2979848079 abstract "Abstract A favourable genetic structure and diversity of behavioural features highlights the potential of dogs for studying the genetic architecture of behaviour traits. However, behaviours are complex traits, which have been shown to be influenced by numerous genetic and non-genetic factors, complicating their analysis. In this study, the genetic contribution to behaviour variation in German Shepherd dogs (GSDs) was analysed using genomic approaches. GSDs were phenotyped for behaviour traits using the established Canine Behavioural Assessment and Research Questionnaire (C-BARQ). Genome-wide association study (GWAS) and regional heritability mapping (RHM) approaches were employed to identify associations between behaviour traits and genetic variants, while accounting for relevant non-genetic factors. By combining these complementary methods we endeavoured to increase the power to detect loci with small effects. Several behavioural traits exhibited moderate heritabilities, with the highest identified for Human-directed playfulness, a trait characterised by positive interactions with humans. We identified several genomic regions associated with one or more of the analysed behaviour traits. Some candidate genes located in these regions were previously linked to behavioural disorders in humans, suggesting a new context for their influence on behaviour characteristics. Overall, the results support dogs as a valuable resource to dissect the genetic architecture of behaviour traits and also highlight the value of focusing on a single breed in order to control for background genetic effects and thus avoid limitations of between-breed analyses." @default.
• W2979848079 created "2019-10-18" @default.
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• W2979848079 date "2019-10-14" @default.
• W2979848079 modified "2023-10-18" @default.
• W2979848079 title "Genetic dissection of complex behaviour traits in German Shepherd dogs" @default.
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• W2979848079 doi "https://doi.org/10.1038/s41437-019-0275-2" @default.
• W2979848079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6834583" @default.
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