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- W2979854906 abstract "Abstract The alteration in cerebral taurine biosynthesis in spontaneously hypertensive rat (SHR) was studied. In the brain of SHR, a statistically significant decrease in the contents of cysteine sulfinic acid, cysteic acid and taurine was detected in the cerebellum, hypothalamus and striatum as compared with those found in normotensive Wistar Kyoto rat (WKR: genetically determined control animal). Similarly, it was found that the activity of cysteine dioxygenase, enzyme catalyzing the oxidation of cysteine, was significantly attenuated in the cerebellum, hypothalamus and striatum of SHR. In contrast, no alteration in the activity of cysteine sulfinic acid decarboxylase was detected in the brain of SHR. The decline of percent conversion of [14C] cysteine to [14C] taurine was also observed in tissue homogenates from the cerebellum, hypothalamus and striatum of SHR. These results indicate that taurine contents in the cerebellum, hypothalamus and striatum of SHR are lower than those found in WKR, possibly due to the attenuation of its biosynthesis. Possible regulatory roles of cysteine dioxygenase activity in the biosynthesis of cerebral taurine are also suggested." @default.
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- W2979854906 date "1983-01-01" @default.
- W2979854906 modified "2023-09-26" @default.
- W2979854906 title "Studies on biosynthetic pathways for taurine in brain(Π > Alterations in spontaneously hypertensive rat (SHR)" @default.
- W2979854906 doi "https://doi.org/10.1016/s0021-5198(19)64790-6" @default.
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