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• W2979876965 abstract "Purpose . To evaluate the wound healing effect of doxycycline and its underlying mechanisms in a rat model of corneal alkali burn. Methods . Male SD rats were administered 1.0 N NaOH in the right cornea for 25 seconds and randomly divided into the doxycycline group and the control group, with 84 rats in each group. 1.0 g·L −1 doxycycline eye drops (doxycycline group) or vehicle (control group) was topically instilled onto the rat cornea after chemical injury. Three days, 7 days, and 14 days after alkali burn, microscopy was used to observe corneal wound healing by fluorescein staining and the degree of corneal opacity. The expression of transforming growth factor-beta 1 (TGF- β 1) and matrix metalloproteinase-9 (MMP-9) was detected by RT-PCR and ELISA, alpha-smooth muscle actin (a-SMA) levels were measured by immunofluorescent staining, and Western blot assays for TGF- β 1, a-SMA, and nuclear factor-kappa B (NF- κ B) were also performed. Results . Corneal wound healing and corneal opacity scores were better in the doxycycline group than in the control group. Three, 7, and 14 days after corneal alkali burn, a significant increase in TGF- β 1 was observed in corneas from the control group, compared with the corneas from the doxycycline group (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>). The corneal levels of MMP-9 in the doxycycline group were lower than those in the control group 3 days and 7 days after alkali burn (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>). In addition, doxycycline inhibited α -SMA expression and suppressed NF- κ B expression. Conclusion . Doxycycline treatment promoted corneal healing and reduced corneal opacity in SD rats. Doxycycline protected the cornea from alkali burn injury by reducing TGF- β 1, MMP-9, NF- κ B, and α -SMA expression." @default.
• W2979876965 created "2019-10-18" @default.
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• W2979876965 date "2019-10-10" @default.
• W2979876965 modified "2023-10-15" @default.
• W2979876965 title "The Wound Healing Effect of Doxycycline after Corneal Alkali Burn in Rats" @default.
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• W2979876965 doi "https://doi.org/10.1155/2019/5168652" @default.
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