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- W2979884048 endingPage "116926" @default.
- W2979884048 startingPage "116926" @default.
- W2979884048 abstract "Sex-related differences in pain and opioids has been the focus of many researches. It is demonstrated that women experience greater clinical pain, lower pain threshold and tolerance, more sensitivity and distress to experimentally induced pain compared to men. Sex differences in response to opioid treatment revealed inconsistent results. However, the etiology of these disparities is not fully elucidated. It is, therefore, conceivable now that this literature merits to be revisited comprehensively. Possible multifaceted factors seem to be associated. These include neuroanatomical, hormonal, neuroimmunological, psychological, social and cultural aspects and comorbidities. This review aims at providing an overview of the substantial literature documenting the sex differences in pain and analgesic response to opioids from animal and human studies within the context of the modulatory effects of the aforementioned factors. A detailed and critical discussion of the cellular and molecular signaling pathways underlying the modulatory actions of gonadal hormones in the sexual dimorphism in pain processing and opioid analgesia is extensively presented. It is indicated that sexual dimorphic activation of certain brain regions contributes to differential pain sensitivity between females and males. Plausible crosstalk between sex hormones and neuroimmunological signaling pertinent to toll-like and purinergic receptors is uncovered as causal cues underlying sexually dimorphic pain and opioid analgesia. Conceivably, a thorough understanding of these factors may aid in sex-related advancement in pain therapeutic management." @default.
- W2979884048 created "2019-10-18" @default.
- W2979884048 creator A5002679863 @default.
- W2979884048 creator A5056280021 @default.
- W2979884048 date "2019-11-01" @default.
- W2979884048 modified "2023-10-14" @default.
- W2979884048 title "Sex differences in pain and opioid mediated antinociception: Modulatory role of gonadal hormones" @default.
- W2979884048 cites W1215373674 @default.
- W2979884048 cites W1570888300 @default.
- W2979884048 cites W1586554549 @default.
- W2979884048 cites W1605865008 @default.
- W2979884048 cites W1758146327 @default.
- W2979884048 cites W1826960795 @default.
- W2979884048 cites W1876803907 @default.
- W2979884048 cites W1913626557 @default.
- W2979884048 cites W1963537578 @default.
- W2979884048 cites W1964792919 @default.
- W2979884048 cites W1966280015 @default.
- W2979884048 cites W1966792230 @default.
- W2979884048 cites W1968764566 @default.
- W2979884048 cites W1973643714 @default.
- W2979884048 cites W1976256751 @default.
- W2979884048 cites W1976669812 @default.
- W2979884048 cites W1976781478 @default.
- W2979884048 cites W1980160645 @default.
- W2979884048 cites W1980674774 @default.
- W2979884048 cites W1981198886 @default.
- W2979884048 cites W1982891583 @default.
- W2979884048 cites W1985002988 @default.
- W2979884048 cites W1985992519 @default.
- W2979884048 cites W1989990363 @default.
- W2979884048 cites W1990367576 @default.
- W2979884048 cites W1990649212 @default.
- W2979884048 cites W1991011825 @default.
- W2979884048 cites W1991153436 @default.
- W2979884048 cites W1991667225 @default.
- W2979884048 cites W1993178542 @default.
- W2979884048 cites W1993672558 @default.
- W2979884048 cites W1995220909 @default.
- W2979884048 cites W1996940368 @default.
- W2979884048 cites W1997001171 @default.
- W2979884048 cites W1997184829 @default.
- W2979884048 cites W1999646306 @default.
- W2979884048 cites W1999889177 @default.
- W2979884048 cites W2000492372 @default.
- W2979884048 cites W2001670468 @default.
- W2979884048 cites W2002534005 @default.
- W2979884048 cites W2003289143 @default.
- W2979884048 cites W2004323875 @default.
- W2979884048 cites W2005172706 @default.
- W2979884048 cites W2007855905 @default.
- W2979884048 cites W2008388511 @default.
- W2979884048 cites W2010404884 @default.
- W2979884048 cites W2014143444 @default.
- W2979884048 cites W2014786081 @default.
- W2979884048 cites W2015366248 @default.
- W2979884048 cites W2016293007 @default.
- W2979884048 cites W2016634891 @default.
- W2979884048 cites W2018808311 @default.
- W2979884048 cites W2020015807 @default.
- W2979884048 cites W2020128213 @default.
- W2979884048 cites W2022382590 @default.
- W2979884048 cites W2023000793 @default.
- W2979884048 cites W2023731184 @default.
- W2979884048 cites W2024424770 @default.
- W2979884048 cites W2025641775 @default.
- W2979884048 cites W2025953250 @default.
- W2979884048 cites W2026595123 @default.
- W2979884048 cites W2026903066 @default.
- W2979884048 cites W2026982851 @default.
- W2979884048 cites W2027618182 @default.
- W2979884048 cites W2027642651 @default.
- W2979884048 cites W2029083566 @default.
- W2979884048 cites W2030867449 @default.
- W2979884048 cites W2032307457 @default.
- W2979884048 cites W2033106089 @default.
- W2979884048 cites W2033470468 @default.
- W2979884048 cites W2034279059 @default.
- W2979884048 cites W2035625905 @default.
- W2979884048 cites W2035888872 @default.
- W2979884048 cites W203651978 @default.
- W2979884048 cites W2036600146 @default.
- W2979884048 cites W2036732725 @default.
- W2979884048 cites W2037146477 @default.
- W2979884048 cites W2038559599 @default.
- W2979884048 cites W2039115160 @default.
- W2979884048 cites W2040653848 @default.
- W2979884048 cites W2045979065 @default.
- W2979884048 cites W2047367913 @default.
- W2979884048 cites W2048320173 @default.
- W2979884048 cites W2048321333 @default.
- W2979884048 cites W2049402964 @default.
- W2979884048 cites W2050571771 @default.
- W2979884048 cites W2052138390 @default.
- W2979884048 cites W2052248328 @default.
- W2979884048 cites W2052317102 @default.
- W2979884048 cites W2052691642 @default.
- W2979884048 cites W2054194137 @default.