Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979886440> ?p ?o ?g. }
- W2979886440 endingPage "112279" @default.
- W2979886440 startingPage "112279" @default.
- W2979886440 abstract "Abstract Parkinson's disease (PD) is a progressive neuropathology characterized by motor and non-motor alterations. β-sitosterol β-d-glucoside (BSSG) is a neurotoxin whose prolonged oral administration in rats has been proposed as a new PD model. Herein, we demonstrate that a single, unilateral, and intranigral administration of BSSG also elicits bilateral sensorimotor alterations in the rat. Six behavioral tests evaluated the effect of different concentrations of BSSG (3, 6, 9, and 12 μg/μL DMSO) from 15 to 120 days after administration. The first behavioral alterations, which appeared on day 15, were unbalanced and uncoordinated gaits and a decrease in the sensorimotor cortex activity, as evidenced by the beam-walking and the vibrissae tests, respectively. After 30 days, the corridor test revealed hyposmia and a decreased locomotor activity in the open field. The last alteration was a depressive-like behavior, as shown by the forced swim test on days 60 and 120. According to the cylinder test, no locomotor asymmetry was observed over time with any BSSG concentrations tested. Also, a mesencephalic TH(+) cell loss (p" @default.
- W2979886440 created "2019-10-18" @default.
- W2979886440 creator A5009553706 @default.
- W2979886440 creator A5010868604 @default.
- W2979886440 creator A5022768721 @default.
- W2979886440 creator A5026720473 @default.
- W2979886440 creator A5027226585 @default.
- W2979886440 creator A5046517943 @default.
- W2979886440 creator A5047691379 @default.
- W2979886440 creator A5049666968 @default.
- W2979886440 creator A5051498950 @default.
- W2979886440 creator A5054993595 @default.
- W2979886440 creator A5061310434 @default.
- W2979886440 creator A5063097729 @default.
- W2979886440 creator A5076166932 @default.
- W2979886440 creator A5084699865 @default.
- W2979886440 date "2020-01-01" @default.
- W2979886440 modified "2023-09-24" @default.
- W2979886440 title "A single intranigral administration of β-sitosterol β-d-glucoside elicits bilateral sensorimotor and non-motor alterations in the rat" @default.
- W2979886440 cites W1527671059 @default.
- W2979886440 cites W1533496890 @default.
- W2979886440 cites W1893133681 @default.
- W2979886440 cites W1970826466 @default.
- W2979886440 cites W1973190490 @default.
- W2979886440 cites W1977267085 @default.
- W2979886440 cites W1986327572 @default.
- W2979886440 cites W1988173316 @default.
- W2979886440 cites W1988204949 @default.
- W2979886440 cites W1990608488 @default.
- W2979886440 cites W1997490477 @default.
- W2979886440 cites W1997798495 @default.
- W2979886440 cites W1998395846 @default.
- W2979886440 cites W2000604066 @default.
- W2979886440 cites W2008257078 @default.
- W2979886440 cites W2013598219 @default.
- W2979886440 cites W2030755872 @default.
- W2979886440 cites W2033611011 @default.
- W2979886440 cites W2048482857 @default.
- W2979886440 cites W2053331667 @default.
- W2979886440 cites W2057541416 @default.
- W2979886440 cites W2064631345 @default.
- W2979886440 cites W2067304480 @default.
- W2979886440 cites W2067866417 @default.
- W2979886440 cites W2073378702 @default.
- W2979886440 cites W2073449985 @default.
- W2979886440 cites W2075093116 @default.
- W2979886440 cites W2082670534 @default.
- W2979886440 cites W2084366703 @default.
- W2979886440 cites W2084979068 @default.
- W2979886440 cites W2106235753 @default.
- W2979886440 cites W2107522917 @default.
- W2979886440 cites W2112054094 @default.
- W2979886440 cites W2128631317 @default.
- W2979886440 cites W2131402502 @default.
- W2979886440 cites W2137522954 @default.
- W2979886440 cites W2142389530 @default.
- W2979886440 cites W2150026124 @default.
- W2979886440 cites W2150202665 @default.
- W2979886440 cites W2158989056 @default.
- W2979886440 cites W2171973513 @default.
- W2979886440 cites W2201320985 @default.
- W2979886440 cites W2463222011 @default.
- W2979886440 cites W2521036148 @default.
- W2979886440 cites W2619861045 @default.
- W2979886440 cites W2727991808 @default.
- W2979886440 cites W2733919684 @default.
- W2979886440 cites W2752602007 @default.
- W2979886440 cites W2770922837 @default.
- W2979886440 cites W2802319189 @default.
- W2979886440 cites W2883611426 @default.
- W2979886440 cites W2921918107 @default.
- W2979886440 cites W4211044101 @default.
- W2979886440 cites W591772137 @default.
- W2979886440 doi "https://doi.org/10.1016/j.bbr.2019.112279" @default.
- W2979886440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31606429" @default.
- W2979886440 hasPublicationYear "2020" @default.
- W2979886440 type Work @default.
- W2979886440 sameAs 2979886440 @default.
- W2979886440 citedByCount "10" @default.
- W2979886440 countsByYear W29798864402020 @default.
- W2979886440 countsByYear W29798864402021 @default.
- W2979886440 countsByYear W29798864402022 @default.
- W2979886440 countsByYear W29798864402023 @default.
- W2979886440 crossrefType "journal-article" @default.
- W2979886440 hasAuthorship W2979886440A5009553706 @default.
- W2979886440 hasAuthorship W2979886440A5010868604 @default.
- W2979886440 hasAuthorship W2979886440A5022768721 @default.
- W2979886440 hasAuthorship W2979886440A5026720473 @default.
- W2979886440 hasAuthorship W2979886440A5027226585 @default.
- W2979886440 hasAuthorship W2979886440A5046517943 @default.
- W2979886440 hasAuthorship W2979886440A5047691379 @default.
- W2979886440 hasAuthorship W2979886440A5049666968 @default.
- W2979886440 hasAuthorship W2979886440A5051498950 @default.
- W2979886440 hasAuthorship W2979886440A5054993595 @default.
- W2979886440 hasAuthorship W2979886440A5061310434 @default.
- W2979886440 hasAuthorship W2979886440A5063097729 @default.
- W2979886440 hasAuthorship W2979886440A5076166932 @default.
- W2979886440 hasAuthorship W2979886440A5084699865 @default.