FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979891585> ?p ?o ?g. }

• W2979891585 endingPage "919" @default.
• W2979891585 startingPage "919" @default.
• W2979891585 abstract "Rift Valley fever virus (RVFV), which causes Rift Valley fever (RVF), is a mosquito-borne zoonotic pathogen that causes serious morbidity and mortality in livestock and humans. RVF is a World Health Organization (WHO) priority disease and, together with rabies, is a major health burden in Africa. Here, we present the development and characterization of an inactivated recombinant RVFV and rabies virus (RABV) vaccine candidate (rSRV9-eGn). Immunization with rSRV9-eGn stimulated the production of RVFV-specific IgG antibodies and induced humoral and cellular immunity in mice but did not induce the production of neutralizing antibodies. IgG1 and IgG2a were the main isotypes observed by IgG subtype detection, and IgG3 antibodies were not detected. The ratios of IgG1/IgG2a > 1 indicated a Type 2 humoral immune response. An effective vaccine is intended to establish a long-lived population of memory T cells, and mice generated memory cells among the proliferating T cell population after immunization with rSRV9-eGn, with effector memory T cells (TEM) as the major population. Due to the lack of prophylactic treatment experiments, it is impossible to predict whether this vaccine can protect animals from RVFV infection with only high titres of anti-RVFV IgG antibodies and no neutralizing antibodies induced, and thus, protection confirmation needs further verification. However, this RVFV vaccine designed with RABV as the vector provides ideas for the development of vaccines that prevent RVFV and RABV infections." @default.
• W2979891585 created "2019-10-18" @default.
• W2979891585 creator A5006028447 @default.
• W2979891585 creator A5007689920 @default.
• W2979891585 creator A5012009078 @default.
• W2979891585 creator A5030044802 @default.
• W2979891585 creator A5034517280 @default.
• W2979891585 creator A5034746165 @default.
• W2979891585 creator A5044480186 @default.
• W2979891585 creator A5055557335 @default.
• W2979891585 creator A5058518849 @default.
• W2979891585 creator A5060507902 @default.
• W2979891585 creator A5066593508 @default.
• W2979891585 creator A5074022590 @default.
• W2979891585 creator A5074140465 @default.
• W2979891585 creator A5074602745 @default.
• W2979891585 creator A5076190187 @default.
• W2979891585 creator A5078204519 @default.
• W2979891585 creator A5080098344 @default.
• W2979891585 creator A5085664675 @default.
• W2979891585 creator A5090800883 @default.
• W2979891585 date "2019-10-08" @default.
• W2979891585 modified "2023-09-26" @default.
• W2979891585 title "Genetically Modified Rabies Virus Vector-Based Rift Valley Fever Virus Vaccine is Safe and Induces Efficacious Immune Responses in Mice" @default.
• W2979891585 cites W1118513983 @default.
• W2979891585 cites W1752709102 @default.
• W2979891585 cites W1870844066 @default.
• W2979891585 cites W1965839715 @default.
• W2979891585 cites W1988441356 @default.
• W2979891585 cites W1989888538 @default.
• W2979891585 cites W1996573913 @default.
• W2979891585 cites W2004541209 @default.
• W2979891585 cites W2019081095 @default.
• W2979891585 cites W2024088157 @default.
• W2979891585 cites W2025320014 @default.
• W2979891585 cites W2050203648 @default.
• W2979891585 cites W2056760766 @default.
• W2979891585 cites W2057110197 @default.
• W2979891585 cites W2062526578 @default.
• W2979891585 cites W2065199367 @default.
• W2979891585 cites W2065785038 @default.
• W2979891585 cites W2098052012 @default.
• W2979891585 cites W2099479563 @default.
• W2979891585 cites W2126562148 @default.
• W2979891585 cites W2127081791 @default.
• W2979891585 cites W2150753192 @default.
• W2979891585 cites W2221955069 @default.
• W2979891585 cites W2256756668 @default.
• W2979891585 cites W2274814902 @default.
• W2979891585 cites W2471631508 @default.
• W2979891585 cites W2515233005 @default.
• W2979891585 cites W2573934367 @default.
• W2979891585 cites W2590826851 @default.
• W2979891585 cites W2605606775 @default.
• W2979891585 cites W2610231130 @default.
• W2979891585 cites W2745757394 @default.
• W2979891585 cites W2745807224 @default.
• W2979891585 cites W2754311886 @default.
• W2979891585 cites W2780743931 @default.
• W2979891585 cites W2785358168 @default.
• W2979891585 cites W2794499311 @default.
• W2979891585 cites W2807407440 @default.
• W2979891585 cites W2893827872 @default.
• W2979891585 cites W2895067807 @default.
• W2979891585 cites W2903660526 @default.
• W2979891585 cites W2906222458 @default.
• W2979891585 cites W2932902987 @default.
• W2979891585 cites W2942161022 @default.
• W2979891585 cites W2950943749 @default.
• W2979891585 cites W2959719126 @default.
• W2979891585 cites W4235010090 @default.
• W2979891585 doi "https://doi.org/10.3390/v11100919" @default.
• W2979891585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6832564" @default.
• W2979891585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31597372" @default.
• W2979891585 hasPublicationYear "2019" @default.
• W2979891585 type Work @default.
• W2979891585 sameAs 2979891585 @default.
• W2979891585 citedByCount "16" @default.
• W2979891585 countsByYear W29798915852020 @default.
• W2979891585 countsByYear W29798915852021 @default.
• W2979891585 countsByYear W29798915852022 @default.
• W2979891585 countsByYear W29798915852023 @default.
• W2979891585 crossrefType "journal-article" @default.
• W2979891585 hasAuthorship W2979891585A5006028447 @default.
• W2979891585 hasAuthorship W2979891585A5007689920 @default.
• W2979891585 hasAuthorship W2979891585A5012009078 @default.
• W2979891585 hasAuthorship W2979891585A5030044802 @default.
• W2979891585 hasAuthorship W2979891585A5034517280 @default.
• W2979891585 hasAuthorship W2979891585A5034746165 @default.
• W2979891585 hasAuthorship W2979891585A5044480186 @default.
• W2979891585 hasAuthorship W2979891585A5055557335 @default.
• W2979891585 hasAuthorship W2979891585A5058518849 @default.
• W2979891585 hasAuthorship W2979891585A5060507902 @default.
• W2979891585 hasAuthorship W2979891585A5066593508 @default.
• W2979891585 hasAuthorship W2979891585A5074022590 @default.
• W2979891585 hasAuthorship W2979891585A5074140465 @default.
• W2979891585 hasAuthorship W2979891585A5074602745 @default.
• W2979891585 hasAuthorship W2979891585A5076190187 @default.

• next