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• W2979944982 abstract "The effect of probiotic therapy on bacterial vaginosis (BV) is controversial. We conducted a meta-analysis of the efficacy and safety associated with probiotic treatment for BV.We searched multiple databases covering up to 1 March 2018. Studies published as blinded randomized controlled trials (RCTs), comparing treatment using probiotic versus active or placebo control in BV patients were included, with at least one-month follow-up. Random effects model and trial sequential analysis (TSA) were applied.Ten studies (n = 2321) were included. Compared with placebo, the probiotics-only therapy resulted in a beneficial outcome both in clinical cure rate at the 30th day (risk ratio, RR = 2.57; 95% confidential interval, 95% CI: 1.96 to 3.37), and Nugent score (mean difference, MD = -2.71; 95% CI: 3.41 to -2.00). This effect decreased but remained significant after eight weeks. Probiotics-post-antibiotics therapy had a decreased effect only for a short term and possibly among studies with a mostly black study population. No extra adverse events were observed. The TSA suggested a larger sample size for effective evaluation of the probiotics as a supplementary remedy.Probiotic regimes are safe and may exhibit a short-term and long-term beneficial effect for BV treatment. The ethnic-specific result for the probiotic used after antibiotics is worthy of further study." @default.
• W2979944982 created "2019-10-18" @default.
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• W2979944982 date "2019-10-12" @default.
• W2979944982 modified "2023-10-06" @default.
• W2979944982 title "Probiotics for the Treatment of Bacterial Vaginosis: A Meta-Analysis" @default.
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• W2979944982 doi "https://doi.org/10.3390/ijerph16203859" @default.
• W2979944982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6848925" @default.
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