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- W2979966268 abstract "Abstract Elucidating the genetic basis of metabolic resistance to insecticides in malaria vectors is crucial to prolonging the effectiveness of insecticide-based control tools including long lasting insecticidal nets (LLINs). Here, we show that cis -regulatory variants of the cytochrome P450 gene, CYP6P9b , are associated with pyrethroid resistance in the African malaria vector Anopheles funestus . A DNA-based assay is designed to track this resistance that occurs near fixation in southern Africa but not in West/Central Africa. Applying this assay we demonstrate, using semi-field experimental huts, that CYP6P9b-mediated resistance associates with reduced effectiveness of LLINs. Furthermore, we establish that CYP6P9b combines with another P450, CYP6P9a , to additively exacerbate the reduced efficacy of insecticide-treated nets. Double homozygote resistant mosquitoes (RR/RR) significantly survive exposure to insecticide-treated nets and successfully blood feed more than other genotypes. This study provides tools to track and assess the impact of multi-gene driven metabolic resistance to pyrethroids, helping improve resistance management." @default.
- W2979966268 created "2019-10-18" @default.
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- W2979966268 date "2019-10-11" @default.
- W2979966268 modified "2023-10-16" @default.
- W2979966268 title "Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus" @default.
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- W2979966268 doi "https://doi.org/10.1038/s41467-019-12686-5" @default.
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