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- W2979983886 abstract "Abstract Canine intracranial meningiomas can be graded based on histological classification as benign (grade I), atypical (grade II), and anaplastic or malignant (grade III). In people, grade II/III meningiomas behave more aggressively, have a higher potential for recurrence after surgical resection, and have lower apparent diffusion coefficient (ADC) values with diffusion weighted imaging (DWI). In this retrospective analytical cross‐sectional study, 42 dogs had ADC values quantified in an attempt to differentiate tumor histologic grade. Our hypothesis was that ADC values would be significantly lower in grade II and III versus grade I meningiomas in dogs. On each ADC image, a polygonal region of interest (ROI) was hand‐drawn along the lesion's periphery, excluding fluid‐filled and hemorrhagic regions. Mean ADC value (ADC mean ) and minimum ADC value (ADC min ) were calculated. Additionally, two smaller, ovoid ROI were drawn within the lesion with mean ADC calculated (ADC mean sR and ADC min sR ). Normalized ADC values using white matter were also calculated (ADC n and ADC n sR ). Grades of each tumor were assigned based on histopathology review. Association between ADC parameters and histological grade was tested by means of two‐sample t ‐tests. There were 14 grade I (33.3%), 25 grade II (59.5%), and three grade III (7.2%) meningiomas. ADC mean sR and ADC min sR were significantly lower when comparing grade II/III to grade I ( P < .05). Grade II tumors had significantly lower ADC mean , ADC mean sR , ADC min sR , ADC n , and ADC n sR than grade I meningiomas. This preliminary study supports the potential of ADC values to help predict the histological grade of intracranial meningiomas in dogs." @default.
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- W2979983886 date "2019-10-10" @default.
- W2979983886 modified "2023-09-27" @default.
- W2979983886 title "Atypical and malignant canine intracranial meningiomas may have lower apparent diffusion coefficient values than benign tumors" @default.
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- W2979983886 doi "https://doi.org/10.1111/vru.12814" @default.
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