Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980004503> ?p ?o ?g. }
- W2980004503 abstract "Respiratory Syncytial Virus (RSV) causes serious respiratory tract illness and substantial morbidity and some mortality in populations at the extremes of age, i.e., infants, young children, and the elderly. To date, RSV vaccine development has been unsuccessful, a feature linked to the lack of biomarkers available to assess the safety and efficacy of RSV vaccine candidates. We examined microRNAs (miR) as potential biomarkers for different types of RSV vaccine candidates. In this study, mice were vaccinated with a live attenuated RSV candidate that lacks the small hydrophobic (SH) and attachment (G) proteins (CP52), an RSV G protein microparticle (GA2-MP) vaccine, a formalin-inactivated RSV (FI-RSV) vaccine or were mock-treated. Several immunological endpoints and miR expression profiles were determined in mouse serum and bronchoalveolar lavage (BAL) following vaccine priming, boost, and RSV challenge. We identified miRs that were linked with immunological parameters of disease and protection. We show that miRs are potential biomarkers providing valuable insights for vaccine development." @default.
- W2980004503 created "2019-10-18" @default.
- W2980004503 creator A5014421292 @default.
- W2980004503 creator A5036238484 @default.
- W2980004503 creator A5053051899 @default.
- W2980004503 creator A5073652963 @default.
- W2980004503 date "2019-10-09" @default.
- W2980004503 modified "2023-10-14" @default.
- W2980004503 title "Determining Immune and miRNA Biomarkers Related to Respiratory Syncytial Virus (RSV) Vaccine Types" @default.
- W2980004503 cites W1503793155 @default.
- W2980004503 cites W1511506873 @default.
- W2980004503 cites W1528331455 @default.
- W2980004503 cites W1537472265 @default.
- W2980004503 cites W1539059755 @default.
- W2980004503 cites W1609044025 @default.
- W2980004503 cites W1799768229 @default.
- W2980004503 cites W1844315553 @default.
- W2980004503 cites W1925673037 @default.
- W2980004503 cites W1938275220 @default.
- W2980004503 cites W1969964905 @default.
- W2980004503 cites W1973047854 @default.
- W2980004503 cites W1980112627 @default.
- W2980004503 cites W1980144092 @default.
- W2980004503 cites W1980780108 @default.
- W2980004503 cites W1986189079 @default.
- W2980004503 cites W1991051577 @default.
- W2980004503 cites W1993466789 @default.
- W2980004503 cites W1998734533 @default.
- W2980004503 cites W1999324217 @default.
- W2980004503 cites W2001173923 @default.
- W2980004503 cites W2007023182 @default.
- W2980004503 cites W2014664666 @default.
- W2980004503 cites W2017549908 @default.
- W2980004503 cites W2018164772 @default.
- W2980004503 cites W2021038135 @default.
- W2980004503 cites W2021996518 @default.
- W2980004503 cites W2022639441 @default.
- W2980004503 cites W2024166644 @default.
- W2980004503 cites W2024339681 @default.
- W2980004503 cites W2026570544 @default.
- W2980004503 cites W2027263955 @default.
- W2980004503 cites W2028532590 @default.
- W2980004503 cites W2031211914 @default.
- W2980004503 cites W2031613673 @default.
- W2980004503 cites W2031806278 @default.
- W2980004503 cites W2032181958 @default.
- W2980004503 cites W2032578603 @default.
- W2980004503 cites W2034978765 @default.
- W2980004503 cites W2035555189 @default.
- W2980004503 cites W2035825518 @default.
- W2980004503 cites W2037388718 @default.
- W2980004503 cites W2040477035 @default.
- W2980004503 cites W2042883762 @default.
- W2980004503 cites W2046180011 @default.
- W2980004503 cites W2046182783 @default.
- W2980004503 cites W2048617927 @default.
- W2980004503 cites W2050155729 @default.
- W2980004503 cites W2066391818 @default.
- W2980004503 cites W2069009920 @default.
- W2980004503 cites W2081113032 @default.
- W2980004503 cites W2088085588 @default.
- W2980004503 cites W2091123450 @default.
- W2980004503 cites W2102690764 @default.
- W2980004503 cites W2102809170 @default.
- W2980004503 cites W2107277218 @default.
- W2980004503 cites W2109732621 @default.
- W2980004503 cites W2111150879 @default.
- W2980004503 cites W2111154902 @default.
- W2980004503 cites W2113034372 @default.
- W2980004503 cites W2113445340 @default.
- W2980004503 cites W2114653354 @default.
- W2980004503 cites W2116555540 @default.
- W2980004503 cites W2118919020 @default.
- W2980004503 cites W2122616510 @default.
- W2980004503 cites W2123682340 @default.
- W2980004503 cites W2125818108 @default.
- W2980004503 cites W2133727134 @default.
- W2980004503 cites W2140461292 @default.
- W2980004503 cites W2148326845 @default.
- W2980004503 cites W2153060237 @default.
- W2980004503 cites W2159482780 @default.
- W2980004503 cites W2160094681 @default.
- W2980004503 cites W2161746509 @default.
- W2980004503 cites W2162674813 @default.
- W2980004503 cites W2163106706 @default.
- W2980004503 cites W2165463148 @default.
- W2980004503 cites W2171225273 @default.
- W2980004503 cites W2175074567 @default.
- W2980004503 cites W2192080449 @default.
- W2980004503 cites W2193720945 @default.
- W2980004503 cites W2194588644 @default.
- W2980004503 cites W2258645079 @default.
- W2980004503 cites W2343080710 @default.
- W2980004503 cites W2406965650 @default.
- W2980004503 cites W2411670982 @default.
- W2980004503 cites W2412707497 @default.
- W2980004503 cites W2470193734 @default.
- W2980004503 cites W2486437856 @default.
- W2980004503 cites W2507788294 @default.
- W2980004503 cites W2509196986 @default.