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- W2980011220 abstract "Farmers are routinely exposed to organic dusts and aeroallergens that can have adverse respiratory health effects including asthma. Horses are farm-reared large animals with similar exposures and can develop equine asthma syndrome (EAS). This review aims to compare the etiology, pathophysiology, and immunology of asthma in horses compared to farmers and highlights the horse as a potential translational animal model for organic dust-induced asthma in humans.Severe EAS shares many clinical and pathological features with various phenotypes of human asthma including allergic, non-allergic, late onset, and severe asthma. EAS disease features include variable airflow obstruction, cough, airway hyperresponsiveness, airway inflammation/remodeling, neutrophilic infiltrates, excess mucus production, and chronic innate immune activation. Severe EAS is a naturally occurring and biologically relevant, translational animal disease model that could contribute to a more thorough understanding of the environmental and immunologic factors contributing to organic dust-induced asthma in humans." @default.
- W2980011220 created "2019-10-18" @default.
- W2980011220 creator A5001733429 @default.
- W2980011220 creator A5005628118 @default.
- W2980011220 creator A5041548914 @default.
- W2980011220 date "2019-10-10" @default.
- W2980011220 modified "2023-09-23" @default.
- W2980011220 title "Comparative Review of Asthma in Farmers and Horses" @default.
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