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- W2980070277 abstract "Abstract The field of colorectal cancer oncology has witnessed major advances in the last decade for the treatment of late-stage cancers using targeted and immune-based therapies. However, there is yet a critical unmet need to develop novel approaches to improve the colorectal cancer prevention. Hereditary colorectal cancer syndromes, mainly Familial Adenomatous Polyposis and Lynch Syndrome, offer a unique opportunity to develop and test the activity of such interventions in high-risk populations displaying an accelerated carcinogenesis. Advances in genomics and systems biology provide unprecedented opportunities to understand the earliest molecular events present in pre-cancer initiation and enable the development of novel strategies to intercept the growth of pre-cancers and their evolution into invasive cancers. In this talk, the speaker will present genomic efforts leveraging next-generation sequencing approaches coupled with big data analysis and will show the potential of this conceptual framework to accelerate advances in cancer prevention that are applicable to other pre-cancers. In addition, challenges inherent to the analysis of pre-cancers and the implementation of clinical studies in Hereditary Cancer Syndromes will be presented. These genomic approaches are likely to bring transformational changes and advances in cancer interception for patients and families with Hereditary Colorectal Cancer Syndromes." @default.
- W2980070277 created "2019-10-18" @default.
- W2980070277 creator A5076039958 @default.
- W2980070277 date "2019-10-01" @default.
- W2980070277 modified "2023-09-24" @default.
- W2980070277 title "Genomic Analyses of Pre-cancers to Accelerate Cancer Interception in Hereditary Colorectal Cancer Syndromes" @default.
- W2980070277 doi "https://doi.org/10.1093/annonc/mdz302.001" @default.
- W2980070277 hasPublicationYear "2019" @default.
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