FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980070413> ?p ?o ?g. }

• W2980070413 endingPage "e1552" @default.
• W2980070413 startingPage "e1541" @default.
• W2980070413 abstract "BackgroundInfant rotavirus vaccines have led to substantial reductions in hospital admissions and deaths due to gastroenteritis, but some studies have reported an elevated risk of intussusception, a rare bowel disorder. This analysis aimed to provide evidence on the potential mortality reduction benefits and intussusception risks of current rotavirus vaccination schedules, and to explore whether alternative schedules could have advantages.MethodsAll 135 low-income and middle-income countries, defined by gross national income per capita of less than US$12 236 in the 2018 fiscal year, were included in the model. Mortality reduction benefits and intussusception risks of rotavirus vaccination were modelled by use of an Excel-based static cohort model with a finely disaggregated age structure. Numbers of rotavirus gastroenteritis deaths and intussusception deaths in each week of age were calculated for all infants born in the year 2015 between birth and age 5·0 years, with and without restrictions on age at administration. Benefit–risk ratios (rotavirus gastroenteritis deaths prevented per excess intussusception death) and other indicators were calculated for two vaccination schedules currently recommended by WHO and 16 alternative schedules. Of these schedules, it was assumed that between one and three doses would be given; the first dose of the rotavirus vaccine would be co-administered with either BCG or diphtheria–tetanus–pertussis (DTP)1; and the second or third dose would be co-administered with either DTP1, DTP2, DTP3, or measles (Meas)1.FindingsA three-dose schedule co-administered with DTP (without age restrictions) could prevent about 74 000 (95% uncertainty interval 59 000–100 000) rotavirus gastroenteritis deaths (38% reduction) and could lead to 201 (77–550) excess intussusception deaths (1·4% increase) compared with no vaccination, resulting in a benefit–risk ratio of 369:1 (160:1–895:1). The benefit–risk ratio was most favourable when the relative risk of intussusception was assumed to decline with the national under-5 mortality rate (2386:1) and least favourable with pessimistic assumptions about access to hospital for intussusception treatment (168:1). Schedules that involve giving the first dose with BCG and the second with DTP1 had the fewest excess intussusception deaths and most favourable benefit–risk ratios.InterpretationRotavirus vaccines have a favourable benefit–risk profile in LMICs. Neonatal schedules have the potential to prevent more rotavirus gastroenteritis deaths and cause fewer excess intussusception deaths than the schedules currently recommended by WHO, but more efficacious rotavirus vaccines would be needed to achieve more substantial mortality reduction benefits.FundingBill & Melinda Gates Foundation." @default.
• W2980070413 created "2019-10-18" @default.
• W2980070413 creator A5012625929 @default.
• W2980070413 creator A5033151792 @default.
• W2980070413 creator A5033321113 @default.
• W2980070413 creator A5037935415 @default.
• W2980070413 creator A5050444974 @default.
• W2980070413 creator A5051281716 @default.
• W2980070413 creator A5054966986 @default.
• W2980070413 creator A5061848201 @default.
• W2980070413 creator A5067911817 @default.
• W2980070413 creator A5073562004 @default.
• W2980070413 creator A5089513385 @default.
• W2980070413 date "2019-11-01" @default.
• W2980070413 modified "2023-10-16" @default.
• W2980070413 title "Mortality reduction benefits and intussusception risks of rotavirus vaccination in 135 low-income and middle-income countries: a modelling analysis of current and alternative schedules" @default.
• W2980070413 cites W1180225333 @default.
• W2980070413 cites W1712434823 @default.
• W2980070413 cites W1972662001 @default.
• W2980070413 cites W1977730005 @default.
• W2980070413 cites W2015222753 @default.
• W2980070413 cites W2068533923 @default.
• W2980070413 cites W2068566053 @default.
• W2980070413 cites W2081808247 @default.
• W2980070413 cites W2091204316 @default.
• W2980070413 cites W2101100687 @default.
• W2980070413 cites W2106595147 @default.
• W2980070413 cites W2107362700 @default.
• W2980070413 cites W2119581587 @default.
• W2980070413 cites W2125434133 @default.
• W2980070413 cites W2126569882 @default.
• W2980070413 cites W2127264038 @default.
• W2980070413 cites W2127516971 @default.
• W2980070413 cites W2154855506 @default.
• W2980070413 cites W2251813897 @default.
• W2980070413 cites W2272999706 @default.
• W2980070413 cites W2281017812 @default.
• W2980070413 cites W2313149862 @default.
• W2980070413 cites W2323433219 @default.
• W2980070413 cites W2325869903 @default.
• W2980070413 cites W2333762130 @default.
• W2980070413 cites W2416791813 @default.
• W2980070413 cites W2606002843 @default.
• W2980070413 cites W2606589148 @default.
• W2980070413 cites W2612574351 @default.
• W2980070413 cites W2755856084 @default.
• W2980070413 cites W2766075783 @default.
• W2980070413 cites W2770589232 @default.
• W2980070413 cites W2785232091 @default.
• W2980070413 cites W2793865752 @default.
• W2980070413 cites W2798152895 @default.
• W2980070413 cites W2800288395 @default.
• W2980070413 cites W2805271490 @default.
• W2980070413 cites W2912128032 @default.
• W2980070413 cites W2922247917 @default.
• W2980070413 cites W2924723274 @default.
• W2980070413 cites W2948888508 @default.
• W2980070413 doi "https://doi.org/10.1016/s2214-109x(19)30412-7" @default.
• W2980070413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7024991" @default.
• W2980070413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31607466" @default.
• W2980070413 hasPublicationYear "2019" @default.
• W2980070413 type Work @default.
• W2980070413 sameAs 2980070413 @default.
• W2980070413 citedByCount "42" @default.
• W2980070413 countsByYear W29800704132019 @default.
• W2980070413 countsByYear W29800704132020 @default.
• W2980070413 countsByYear W29800704132021 @default.
• W2980070413 countsByYear W29800704132022 @default.
• W2980070413 countsByYear W29800704132023 @default.
• W2980070413 crossrefType "journal-article" @default.
• W2980070413 hasAuthorship W2980070413A5012625929 @default.
• W2980070413 hasAuthorship W2980070413A5033151792 @default.
• W2980070413 hasAuthorship W2980070413A5033321113 @default.
• W2980070413 hasAuthorship W2980070413A5037935415 @default.
• W2980070413 hasAuthorship W2980070413A5050444974 @default.
• W2980070413 hasAuthorship W2980070413A5051281716 @default.
• W2980070413 hasAuthorship W2980070413A5054966986 @default.
• W2980070413 hasAuthorship W2980070413A5061848201 @default.
• W2980070413 hasAuthorship W2980070413A5067911817 @default.
• W2980070413 hasAuthorship W2980070413A5073562004 @default.
• W2980070413 hasAuthorship W2980070413A5089513385 @default.
• W2980070413 hasBestOaLocation W29800704131 @default.
• W2980070413 hasConcept C126322002 @default.
• W2980070413 hasConcept C141071460 @default.
• W2980070413 hasConcept C144024400 @default.
• W2980070413 hasConcept C149923435 @default.
• W2980070413 hasConcept C187212893 @default.
• W2980070413 hasConcept C203014093 @default.
• W2980070413 hasConcept C22070199 @default.
• W2980070413 hasConcept C2776438120 @default.
• W2980070413 hasConcept C2777227250 @default.
• W2980070413 hasConcept C2777831738 @default.
• W2980070413 hasConcept C2779802037 @default.
• W2980070413 hasConcept C2779841045 @default.
• W2980070413 hasConcept C2781367151 @default.
• W2980070413 hasConcept C71924100 @default.
• W2980070413 hasConcept C99454951 @default.
• W2980070413 hasConceptScore W2980070413C126322002 @default.

• next