FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980072390> ?p ?o ?g. }

• W2980072390 endingPage "1685" @default.
• W2980072390 startingPage "1677" @default.
• W2980072390 abstract "Similar to the mesenchymal stem cells (MSCs), dental pulp stem cells (DPSCs) also have pluripotent differentiation characteristic and may be more ideal for tissue regeneration, especially in tooth regeneration engineering. However, bacterial infection may be a powerful obstacle. Berberine (BBR), known with antibacterial effects, was recently found to play functions in bone formation through promoting osteogenic differentiation from pluripotent stem cells. However, whether BBR also function in DPSCs osteogenic differentiation has not yet been reported. Primary DPSCs were isolated from dental pulp tissues extracted from human impacted mandibular third molars, and identified by flow cytometry for cell surface antigen molecules. A dexamethasone osteogenic medium was used to induce DPSCs osteogenic differentiation. BBR (1 μM and 5 μM) was pre-added to into medium, and then cell proliferation, spheroid formation and osteogenic differentiation capacities of DPSCs were analyzed, as well as the underlying molecules modulation mechanism. Flow cytometry identified that CD44, CD90, CD81 and CD105 positively expressed in the isolated hDPSCs, with CD34 and CD45 negetively expressed. BBR enhanced the cell proliferation of hDPSCs in a dose-dependent pattern, and promoted dexamethasone-induced osteogenic differentiation via enhancing Runx2 transcription factor activity followed by upregulating osteogenesis markers expression, whereas the adipogenic differentiation of hDPSCs was suppressed dramatically by BBR. The EGFR and MAPK pathways were activated by BBR, and inhibitors for these pathways significantly suppressed the osteogenic differentiation promotion of BBR. These results have revealed a novel mechanism that berberine might promote hDPSCs osteogenic differentiation through activating EGFR-MAPK-Runx2 signaling pathways." @default.
• W2980072390 created "2019-10-18" @default.
• W2980072390 creator A5002661071 @default.
• W2980072390 creator A5009053906 @default.
• W2980072390 creator A5042710203 @default.
• W2980072390 creator A5048931322 @default.
• W2980072390 creator A5052686179 @default.
• W2980072390 creator A5082878280 @default.
• W2980072390 date "2019-10-09" @default.
• W2980072390 modified "2023-09-30" @default.
• W2980072390 title "Berberine Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells Through Activating EGFR-MAPK-Runx2 Pathways" @default.
• W2980072390 cites W1508803320 @default.
• W2980072390 cites W1767511027 @default.
• W2980072390 cites W1994596418 @default.
• W2980072390 cites W2006089345 @default.
• W2980072390 cites W2012158163 @default.
• W2980072390 cites W2024898870 @default.
• W2980072390 cites W2029656920 @default.
• W2980072390 cites W2059769954 @default.
• W2980072390 cites W2060630008 @default.
• W2980072390 cites W2066371393 @default.
• W2980072390 cites W2071091332 @default.
• W2980072390 cites W2080513978 @default.
• W2980072390 cites W2092233035 @default.
• W2980072390 cites W2098575356 @default.
• W2980072390 cites W2108794443 @default.
• W2980072390 cites W2130516299 @default.
• W2980072390 cites W2139519181 @default.
• W2980072390 cites W2171777896 @default.
• W2980072390 cites W2326196285 @default.
• W2980072390 cites W2435987423 @default.
• W2980072390 cites W2491684481 @default.
• W2980072390 cites W2529338296 @default.
• W2980072390 cites W2617951505 @default.
• W2980072390 cites W2794174459 @default.
• W2980072390 cites W2797903287 @default.
• W2980072390 cites W2800178728 @default.
• W2980072390 cites W2805787330 @default.
• W2980072390 cites W2807361503 @default.
• W2980072390 cites W2810204213 @default.
• W2980072390 doi "https://doi.org/10.1007/s12253-019-00746-6" @default.
• W2980072390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31598896" @default.
• W2980072390 hasPublicationYear "2019" @default.
• W2980072390 type Work @default.
• W2980072390 sameAs 2980072390 @default.
• W2980072390 citedByCount "24" @default.
• W2980072390 countsByYear W29800723902020 @default.
• W2980072390 countsByYear W29800723902021 @default.
• W2980072390 countsByYear W29800723902022 @default.
• W2980072390 countsByYear W29800723902023 @default.
• W2980072390 crossrefType "journal-article" @default.
• W2980072390 hasAuthorship W2980072390A5002661071 @default.
• W2980072390 hasAuthorship W2980072390A5009053906 @default.
• W2980072390 hasAuthorship W2980072390A5042710203 @default.
• W2980072390 hasAuthorship W2980072390A5048931322 @default.
• W2980072390 hasAuthorship W2980072390A5052686179 @default.
• W2980072390 hasAuthorship W2980072390A5082878280 @default.
• W2980072390 hasConcept C10205521 @default.
• W2980072390 hasConcept C104317684 @default.
• W2980072390 hasConcept C116716535 @default.
• W2980072390 hasConcept C148738053 @default.
• W2980072390 hasConcept C1491633281 @default.
• W2980072390 hasConcept C185592680 @default.
• W2980072390 hasConcept C198826908 @default.
• W2980072390 hasConcept C202751555 @default.
• W2980072390 hasConcept C2776363554 @default.
• W2980072390 hasConcept C2777400515 @default.
• W2980072390 hasConcept C2778260815 @default.
• W2980072390 hasConcept C2780932548 @default.
• W2980072390 hasConcept C28328180 @default.
• W2980072390 hasConcept C55493867 @default.
• W2980072390 hasConcept C57074206 @default.
• W2980072390 hasConcept C62478195 @default.
• W2980072390 hasConcept C86803240 @default.
• W2980072390 hasConcept C95444343 @default.
• W2980072390 hasConceptScore W2980072390C10205521 @default.
• W2980072390 hasConceptScore W2980072390C104317684 @default.
• W2980072390 hasConceptScore W2980072390C116716535 @default.
• W2980072390 hasConceptScore W2980072390C148738053 @default.
• W2980072390 hasConceptScore W2980072390C1491633281 @default.
• W2980072390 hasConceptScore W2980072390C185592680 @default.
• W2980072390 hasConceptScore W2980072390C198826908 @default.
• W2980072390 hasConceptScore W2980072390C202751555 @default.
• W2980072390 hasConceptScore W2980072390C2776363554 @default.
• W2980072390 hasConceptScore W2980072390C2777400515 @default.
• W2980072390 hasConceptScore W2980072390C2778260815 @default.
• W2980072390 hasConceptScore W2980072390C2780932548 @default.
• W2980072390 hasConceptScore W2980072390C28328180 @default.
• W2980072390 hasConceptScore W2980072390C55493867 @default.
• W2980072390 hasConceptScore W2980072390C57074206 @default.
• W2980072390 hasConceptScore W2980072390C62478195 @default.
• W2980072390 hasConceptScore W2980072390C86803240 @default.
• W2980072390 hasConceptScore W2980072390C95444343 @default.
• W2980072390 hasIssue "3" @default.
• W2980072390 hasLocation W29800723901 @default.
• W2980072390 hasOpenAccess W2980072390 @default.
• W2980072390 hasPrimaryLocation W29800723901 @default.
• W2980072390 hasRelatedWork W1988356236 @default.

• next