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• W2980138715 abstract "Abstract Anticancer properties of non-psychoactive cannabinoid cannabidiol (CBD) have been demonstrated on tumors of different histogenesis. Different molecular targets for CBD were proposed, including cannabinoid receptors and some plasma membrane ion channels. Here we have shown that cell lines derived from acute lymphoblastic leukemia of T lineage (T-ALL), but not resting healthy T cells, are highly sensitive to CBD treatment. CBD effect does not depend on cannabinoid receptors or plasma membrane Ca 2+ -permeable channels. Instead, CBD directly targets mitochondria and alters their capacity to handle Ca 2+ . At lethal concentrations, CBD causes mitochondrial Ca 2+ overload, stable mitochondrial transition pore formation and cell death. Our results suggest that CBD is an attractive candidate to be included into chemotherapeutic protocols for T-ALL treatment." @default.
• W2980138715 created "2019-10-18" @default.
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• W2980138715 date "2019-10-14" @default.
• W2980138715 modified "2023-10-14" @default.
• W2980138715 title "Cannabidiol directly targets mitochondria and disturbs calcium homeostasis in acute lymphoblastic leukemia" @default.
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• W2980138715 doi "https://doi.org/10.1038/s41419-019-2024-0" @default.
• W2980138715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6791884" @default.
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• W2980138715 hasPublicationYear "2019" @default.
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