FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980191806> ?p ?o ?g. }

• W2980191806 endingPage "2193" @default.
• W2980191806 startingPage "2193" @default.
• W2980191806 abstract "Abstract Abstract 2193 Poster Board II-170 Background: Despite the success of imatinib mesylate in treating patients with CML, several pts develop resistance to therapy. In addition, response rate for pts in accelerated (AP) or blast (BP) phase is significantly lower than in chronic phase (cp) and responses are usually short-lived. Omacetaxine (homoharringtonine) is a plant alkaloid extracted from cephalotaxus fortunei, with in vitro and clinical activity in CML. In vitro experience has shown synergy of omacetaxine combined with imatinib (Ref). Aim: Evaluate the safety and efficacy of intravenous omacetaxine combined with imatinib in the treatment of patients with CML in CP, AP, or BP. Methods: Patients with CML were eligible if they had 1) CP resistant to single agent imatinib, or 2) AP or BP, regardless of prior exposure to imatinib. Pts received omacetaxine 2.5 mg/m2 by 24-hour continuous infusion daily for 5 days (days 1-5 of each cycle) every 4 weeks and imatinib, 400 mg daily for pts in CP and 600 mg daily for pts in AP or BP. Results: Fifteen pts were enrolled: 9 in BP, 3 in AP, and 3 in CP. The median age is 55 years (range, 21-77); median time from diagnosis to treatment 35 months (range, 1 to 139). Twelve pts (80%) were imatinib resistant. Three pts had not received imatinib (all in BP; one had received prior interferon and stem cell transplant). Eight pts had received treatment with at least one other tyrosine kinase inhibitor beside imatinib. Mutation analysis was performed in 14 out of 15 pts and 7 had mutations (T315I in 3, F317L in 2, F359V and Q252H one each). Patients received a median of 3 cycles 4 (1-34). Eight (53%) pts responded. Hematologic response was achieved in 7 of 14 evaluable pts (1 started in CHR): 3 CHR (all BP), and 4 BCP (3 BP, 1 AP). Cytogenetic responses were achieved in 4 (of 14)pts(28%): 2 complete , 1 partial and 1 minor (BP) and one of the pt in CR later achieved complete molecular response. Responses were usually transient although one pt (BP) remains in complete molecular remission 42 months from the start of therapy. One pt died of unrelated causes while in major cytogenetic response 12 months after start of therapy, and one pt changed therapy with an ongoing minor cytogenetic response after 13 months. Therapy was overall well tolerated and administered on outpatient basis. Grade 3-4 non hematologic toxicity (regardless of causality) included fatigue (20%), nausea & vomiting (13%), dizziness (7%) and weight loss (6%). Grade 3-4 hematologic toxicity included thrombocytopenia (93%), anemia (80%), and neutropenia (80%). Transient treatment interruptions were required in 6 patients because of myelosuppression. The median survival is 4.7 months. Three patients are alive, 35, 41 and 42 months from start of therapy: 1 still on therapy with complete molecular response; 1 with complete cytogenetic remission on bosutinib, and one (T315I) on hydroxyurea. Conclusion: Omacetaxine combined with imatinib is effective in patients with advanced stages of CML and has a favorable toxicity profile. Further studies with this combination are warranted, particularly in advanced phase CML. Disclosures: Cortes-Franco: Chemgenex: Research Funding; Novartis: Research Funding." @default.
• W2980191806 created "2019-10-18" @default.
• W2980191806 creator A5003239545 @default.
• W2980191806 creator A5028845635 @default.
• W2980191806 creator A5040299848 @default.
• W2980191806 creator A5079303243 @default.
• W2980191806 creator A5084290698 @default.
• W2980191806 creator A5089428686 @default.
• W2980191806 creator A5090435894 @default.
• W2980191806 date "2009-11-20" @default.
• W2980191806 modified "2023-10-01" @default.
• W2980191806 title "A Phase 2 study of the Combination of Omacetaxine and Imatinib in the Treatment of Patients with Chronic Myeloid Leukemia (CML) in Advanced Stages or After Failure to Imatinib." @default.
• W2980191806 doi "https://doi.org/10.1182/blood.v114.22.2193.2193" @default.
• W2980191806 hasPublicationYear "2009" @default.
• W2980191806 type Work @default.
• W2980191806 sameAs 2980191806 @default.
• W2980191806 citedByCount "3" @default.
• W2980191806 countsByYear W29801918062012 @default.
• W2980191806 countsByYear W29801918062013 @default.
• W2980191806 crossrefType "journal-article" @default.
• W2980191806 hasAuthorship W2980191806A5003239545 @default.
• W2980191806 hasAuthorship W2980191806A5028845635 @default.
• W2980191806 hasAuthorship W2980191806A5040299848 @default.
• W2980191806 hasAuthorship W2980191806A5079303243 @default.
• W2980191806 hasAuthorship W2980191806A5084290698 @default.
• W2980191806 hasAuthorship W2980191806A5089428686 @default.
• W2980191806 hasAuthorship W2980191806A5090435894 @default.
• W2980191806 hasConcept C121608353 @default.
• W2980191806 hasConcept C126322002 @default.
• W2980191806 hasConcept C141071460 @default.
• W2980191806 hasConcept C143998085 @default.
• W2980191806 hasConcept C2777583451 @default.
• W2980191806 hasConcept C2778729363 @default.
• W2980191806 hasConcept C2778820342 @default.
• W2980191806 hasConcept C2910157418 @default.
• W2980191806 hasConcept C3019892230 @default.
• W2980191806 hasConcept C71924100 @default.
• W2980191806 hasConcept C90924648 @default.
• W2980191806 hasConcept C98274493 @default.
• W2980191806 hasConceptScore W2980191806C121608353 @default.
• W2980191806 hasConceptScore W2980191806C126322002 @default.
• W2980191806 hasConceptScore W2980191806C141071460 @default.
• W2980191806 hasConceptScore W2980191806C143998085 @default.
• W2980191806 hasConceptScore W2980191806C2777583451 @default.
• W2980191806 hasConceptScore W2980191806C2778729363 @default.
• W2980191806 hasConceptScore W2980191806C2778820342 @default.
• W2980191806 hasConceptScore W2980191806C2910157418 @default.
• W2980191806 hasConceptScore W2980191806C3019892230 @default.
• W2980191806 hasConceptScore W2980191806C71924100 @default.
• W2980191806 hasConceptScore W2980191806C90924648 @default.
• W2980191806 hasConceptScore W2980191806C98274493 @default.
• W2980191806 hasIssue "22" @default.
• W2980191806 hasLocation W29801918061 @default.
• W2980191806 hasOpenAccess W2980191806 @default.
• W2980191806 hasPrimaryLocation W29801918061 @default.
• W2980191806 hasRelatedWork W1554937972 @default.
• W2980191806 hasRelatedWork W1921369781 @default.
• W2980191806 hasRelatedWork W2038119532 @default.
• W2980191806 hasRelatedWork W2073439508 @default.
• W2980191806 hasRelatedWork W2079968296 @default.
• W2980191806 hasRelatedWork W2120077570 @default.
• W2980191806 hasRelatedWork W2121321278 @default.
• W2980191806 hasRelatedWork W2273178174 @default.
• W2980191806 hasRelatedWork W2738032586 @default.
• W2980191806 hasRelatedWork W2187195062 @default.
• W2980191806 hasVolume "114" @default.
• W2980191806 isParatext "false" @default.
• W2980191806 isRetracted "false" @default.
• W2980191806 magId "2980191806" @default.
• W2980191806 workType "article" @default.