Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980194015> ?p ?o ?g. }
- W2980194015 endingPage "11680" @default.
- W2980194015 startingPage "11667" @default.
- W2980194015 abstract "Abstract DNA mismatch repair (MMR) maintains genome stability through repair of DNA replication errors. In Escherichia coli, initiation of MMR involves recognition of the mismatch by MutS, recruitment of MutL, activation of endonuclease MutH and DNA strand incision at a hemimethylated GATC site. Here, we studied the mechanism of communication that couples mismatch recognition to daughter strand incision. We investigated the effect of catalytically-deficient Cas9 as well as stalled RNA polymerase as roadblocks placed on DNA in between the mismatch and GATC site in ensemble and single molecule nanomanipulation incision assays. The MMR proteins were observed to incise GATC sites beyond a roadblock, albeit with reduced efficiency. This residual incision is completely abolished upon shortening the disordered linker regions of MutL. These results indicate that roadblock bypass can be fully attributed to the long, disordered linker regions in MutL and establish that communication during MMR initiation occurs along the DNA backbone." @default.
- W2980194015 created "2019-10-18" @default.
- W2980194015 creator A5002578012 @default.
- W2980194015 creator A5003301414 @default.
- W2980194015 creator A5011014479 @default.
- W2980194015 creator A5023204894 @default.
- W2980194015 creator A5037396962 @default.
- W2980194015 creator A5038398625 @default.
- W2980194015 creator A5045220419 @default.
- W2980194015 creator A5047204594 @default.
- W2980194015 creator A5061336324 @default.
- W2980194015 creator A5072025848 @default.
- W2980194015 creator A5078989047 @default.
- W2980194015 creator A5079816248 @default.
- W2980194015 date "2019-10-10" @default.
- W2980194015 modified "2023-10-14" @default.
- W2980194015 title "The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair" @default.
- W2980194015 cites W1561143138 @default.
- W2980194015 cites W1577360400 @default.
- W2980194015 cites W1577713059 @default.
- W2980194015 cites W1585911315 @default.
- W2980194015 cites W159335997 @default.
- W2980194015 cites W1607945477 @default.
- W2980194015 cites W1843397982 @default.
- W2980194015 cites W1917300465 @default.
- W2980194015 cites W1924084608 @default.
- W2980194015 cites W1970196890 @default.
- W2980194015 cites W1972018037 @default.
- W2980194015 cites W1974527579 @default.
- W2980194015 cites W1984467885 @default.
- W2980194015 cites W1991387734 @default.
- W2980194015 cites W1993964809 @default.
- W2980194015 cites W2004723279 @default.
- W2980194015 cites W2006760092 @default.
- W2980194015 cites W2007446614 @default.
- W2980194015 cites W2009608382 @default.
- W2980194015 cites W2010194741 @default.
- W2980194015 cites W2014785893 @default.
- W2980194015 cites W2016286342 @default.
- W2980194015 cites W2026995122 @default.
- W2980194015 cites W2029780301 @default.
- W2980194015 cites W2030776726 @default.
- W2980194015 cites W2033361357 @default.
- W2980194015 cites W2033639747 @default.
- W2980194015 cites W2034482517 @default.
- W2980194015 cites W2035765657 @default.
- W2980194015 cites W2037816942 @default.
- W2980194015 cites W2042785161 @default.
- W2980194015 cites W2045435533 @default.
- W2980194015 cites W2048836313 @default.
- W2980194015 cites W2051924844 @default.
- W2980194015 cites W2057152177 @default.
- W2980194015 cites W2057709034 @default.
- W2980194015 cites W2067215249 @default.
- W2980194015 cites W2075182125 @default.
- W2980194015 cites W2075271539 @default.
- W2980194015 cites W2076300945 @default.
- W2980194015 cites W2078319055 @default.
- W2980194015 cites W2082975917 @default.
- W2980194015 cites W2084744901 @default.
- W2980194015 cites W2089760271 @default.
- W2980194015 cites W2096331487 @default.
- W2980194015 cites W2097225979 @default.
- W2980194015 cites W2106101609 @default.
- W2980194015 cites W2115062176 @default.
- W2980194015 cites W2118131517 @default.
- W2980194015 cites W2118337143 @default.
- W2980194015 cites W2120881407 @default.
- W2980194015 cites W2123540648 @default.
- W2980194015 cites W2124295966 @default.
- W2980194015 cites W2137618022 @default.
- W2980194015 cites W2140611425 @default.
- W2980194015 cites W2141323033 @default.
- W2980194015 cites W2143675334 @default.
- W2980194015 cites W2145803410 @default.
- W2980194015 cites W2157560413 @default.
- W2980194015 cites W2164015357 @default.
- W2980194015 cites W2166973961 @default.
- W2980194015 cites W2167279371 @default.
- W2980194015 cites W2171732965 @default.
- W2980194015 cites W2182089335 @default.
- W2980194015 cites W2186358235 @default.
- W2980194015 cites W2188713308 @default.
- W2980194015 cites W2260480416 @default.
- W2980194015 cites W2376940437 @default.
- W2980194015 cites W2390421705 @default.
- W2980194015 cites W2413493645 @default.
- W2980194015 cites W2551721425 @default.
- W2980194015 cites W2558002100 @default.
- W2980194015 cites W2586867260 @default.
- W2980194015 cites W2771417816 @default.
- W2980194015 cites W2808519941 @default.
- W2980194015 cites W2895603808 @default.
- W2980194015 cites W2949178188 @default.
- W2980194015 cites W2973731348 @default.
- W2980194015 doi "https://doi.org/10.1093/nar/gkz834" @default.
- W2980194015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6902014" @default.
- W2980194015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31598722" @default.