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- W2980212891 abstract "The objective of this study was to examine the anti-colitis activity of Jakyakgamcho-tang (JGT) in dextran sulfate sodium (DSS)-induced colitis and explore changes of the gut microbial community using 16S rRNA amplicon sequencing and metabolomics approaches. It was found that treatment with JGT or 5-aminosalicylic acid (5-ASA) alleviated the severity of colitis symptoms by suppressing inflammatory cytokine levels of IL-6, IL-12, and IFN-γ. The non-metric multidimensional scaling analysis of gut microbiome revealed that JGT groups were clearly separated from the DSS group, suggesting that JGT administration altered gut microbiota. The operational taxonomic units (OTUs) that were decreased by DSS but increased by JGT include Akkermansia and Allobaculum. On the other hand, OTUs that were increased by DSS but decreased by 5-ASA or JGT treatments include Bacteroidales S24-7, Ruminococcaceae, and Rikenellaceae, and the genera Bacteroides, Parabacteroides, Oscillospira, and Coprobacillus. After JGT administration, the metabolites, including most amino acids and lactic acid that were altered by colitis induction, became similar to those of the control group. This study demonstrates that JGT might have potential to effectively treat colitis by restoring dysbiosis of gut microbiota and host metabolites." @default.
- W2980212891 created "2019-10-18" @default.
- W2980212891 creator A5026014755 @default.
- W2980212891 creator A5040432537 @default.
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- W2980212891 creator A5080555312 @default.
- W2980212891 creator A5088022966 @default.
- W2980212891 date "2019-10-14" @default.
- W2980212891 modified "2023-09-26" @default.
- W2980212891 title "Korean Traditional Medicine (Jakyakgamcho-tang) Ameliorates Colitis by Regulating Gut Microbiota" @default.
- W2980212891 cites W1492754204 @default.
- W2980212891 cites W1505961841 @default.
- W2980212891 cites W1555574479 @default.
- W2980212891 cites W1597959509 @default.
- W2980212891 cites W1702435110 @default.
- W2980212891 cites W1867482183 @default.
- W2980212891 cites W1875987752 @default.
- W2980212891 cites W1914679235 @default.
- W2980212891 cites W1919048856 @default.
- W2980212891 cites W1946762479 @default.
- W2980212891 cites W1965018721 @default.
- W2980212891 cites W1974590491 @default.
- W2980212891 cites W1980914602 @default.
- W2980212891 cites W1991723267 @default.
- W2980212891 cites W2002496324 @default.
- W2980212891 cites W2003955379 @default.
- W2980212891 cites W2009671191 @default.
- W2980212891 cites W2009706335 @default.
- W2980212891 cites W2013170543 @default.
- W2980212891 cites W2016223756 @default.
- W2980212891 cites W2016742425 @default.
- W2980212891 cites W2020398205 @default.
- W2980212891 cites W2027659227 @default.
- W2980212891 cites W2032230795 @default.
- W2980212891 cites W2034285706 @default.
- W2980212891 cites W2034382475 @default.
- W2980212891 cites W2036256897 @default.
- W2980212891 cites W2036258026 @default.
- W2980212891 cites W2041446227 @default.
- W2980212891 cites W2041613547 @default.
- W2980212891 cites W2048853985 @default.
- W2980212891 cites W2052683847 @default.
- W2980212891 cites W2053244592 @default.
- W2980212891 cites W2058181781 @default.
- W2980212891 cites W2067143265 @default.
- W2980212891 cites W2070402792 @default.
- W2980212891 cites W2071644653 @default.
- W2980212891 cites W2072488504 @default.
- W2980212891 cites W2074080336 @default.
- W2980212891 cites W2078430207 @default.
- W2980212891 cites W2085150031 @default.
- W2980212891 cites W2086465908 @default.
- W2980212891 cites W2090256856 @default.
- W2980212891 cites W2090711753 @default.
- W2980212891 cites W2095161324 @default.
- W2980212891 cites W2098973659 @default.
- W2980212891 cites W2103970981 @default.
- W2980212891 cites W2108718991 @default.
- W2980212891 cites W2111362292 @default.
- W2980212891 cites W2116224125 @default.
- W2980212891 cites W2119864240 @default.
- W2980212891 cites W2125826054 @default.
- W2980212891 cites W2133856765 @default.
- W2980212891 cites W2134241692 @default.
- W2980212891 cites W2138119117 @default.
- W2980212891 cites W2139334262 @default.
- W2980212891 cites W2139343480 @default.
- W2980212891 cites W2139958597 @default.
- W2980212891 cites W2150968312 @default.
- W2980212891 cites W2154026962 @default.
- W2980212891 cites W2170729963 @default.
- W2980212891 cites W2260815707 @default.
- W2980212891 cites W2282124923 @default.
- W2980212891 cites W2290702494 @default.
- W2980212891 cites W2328023807 @default.
- W2980212891 cites W2404854108 @default.
- W2980212891 cites W2473313158 @default.
- W2980212891 cites W2513506562 @default.
- W2980212891 cites W2534977774 @default.
- W2980212891 cites W2566680380 @default.
- W2980212891 cites W2567490210 @default.
- W2980212891 cites W2576537216 @default.
- W2980212891 cites W2587895783 @default.
- W2980212891 cites W2594894350 @default.
- W2980212891 cites W2597502341 @default.
- W2980212891 cites W2736839127 @default.
- W2980212891 cites W2755726563 @default.
- W2980212891 cites W2774055894 @default.
- W2980212891 cites W2783681062 @default.
- W2980212891 cites W2788222993 @default.
- W2980212891 cites W2792021903 @default.
- W2980212891 cites W2807728333 @default.
- W2980212891 cites W2890404977 @default.
- W2980212891 cites W2914417988 @default.
- W2980212891 cites W2937401606 @default.
- W2980212891 cites W2951005150 @default.