FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980218129> ?p ?o ?g. }

• W2980218129 endingPage "273" @default.
• W2980218129 startingPage "263" @default.
• W2980218129 abstract "An accurate profiling of the genomic landscape is mandatory to establish the best clinical and therapeutic approach for patients with solid malignancies. Moreover, tumor cells constantly adapt to external pressures-i.e., systemic treatment-with the selection and expansion of resistant subclones and the emergence of heterogeneous overlapping genomic alterations of resistance. The current standard for molecular characterization in cancer is the performance of a tissue tumor biopsy at the time of diagnosis and, when possible, a re-biopsy at the time of progression. However, tissue biopsy is not always feasible or practical and may underestimate tumor heterogeneity and clonal dynamics. Circulating DNA fragments carrying tumor-specific sequence alterations (circulating tumor DNA, ctDNA) are released from cancer cells into the bloodstream, representing a variable and generally small fraction of the total circulating cell-free DNA. Tumor genotyping in ctDNA (liquid biopsy) offers potential advantages versus the standard tumor tissue biopsy, including non-invasiveness and representation of molecular heterogeneity. Technical advances in sequencing platforms have led to dramatic improvements in variant detection sensitivity and specificity that allow for the detection and quantification of low levels of ctDNA. This provides valuable information on both actionable mutations and captures real-time variations in tumor dynamics. Liquid biopsy clinical applications include molecular diagnosis, determination of tumor load as a surrogate marker of early response, monitoring of mutations of resistance to targeted therapy and detection of minimal residual disease after cancer surgery. The aim of this chapter is to provide an overview of the biological rational and technical background of ctDNA analysis, as well as on the main clinical applications of liquid biopsy in dynamic treatment stratification in solid tumors. Special emphasis will be made on the current and potential benefits of the implementation of ctDNA in clinical practice, mainly in melanoma, lung, and colorectal cancer." @default.
• W2980218129 created "2019-10-18" @default.
• W2980218129 creator A5000601939 @default.
• W2980218129 creator A5001410842 @default.
• W2980218129 creator A5083616708 @default.
• W2980218129 date "2019-10-12" @default.
• W2980218129 modified "2023-10-16" @default.
• W2980218129 title "Dynamic Treatment Stratification Using ctDNA" @default.
• W2980218129 cites W1888871611 @default.
• W2980218129 cites W2006168411 @default.
• W2980218129 cites W2007513598 @default.
• W2980218129 cites W2022465587 @default.
• W2980218129 cites W2027371008 @default.
• W2980218129 cites W2027735722 @default.
• W2980218129 cites W2041919461 @default.
• W2980218129 cites W2062109911 @default.
• W2980218129 cites W2103724490 @default.
• W2980218129 cites W2107503225 @default.
• W2980218129 cites W2116731538 @default.
• W2980218129 cites W2140575188 @default.
• W2980218129 cites W2141630197 @default.
• W2980218129 cites W2154018281 @default.
• W2980218129 cites W2167806838 @default.
• W2980218129 cites W2169198176 @default.
• W2980218129 cites W2171237493 @default.
• W2980218129 cites W2177855755 @default.
• W2980218129 cites W2191042712 @default.
• W2980218129 cites W2468983064 @default.
• W2980218129 cites W2498387096 @default.
• W2980218129 cites W2529353322 @default.
• W2980218129 cites W2560160922 @default.
• W2980218129 cites W2570618306 @default.
• W2980218129 cites W2588078993 @default.
• W2980218129 cites W2592144107 @default.
• W2980218129 cites W2607200433 @default.
• W2980218129 cites W2607977201 @default.
• W2980218129 cites W2766399158 @default.
• W2980218129 cites W2783576981 @default.
• W2980218129 cites W2789230459 @default.
• W2980218129 cites W2791176983 @default.
• W2980218129 cites W2792093743 @default.
• W2980218129 cites W2901178367 @default.
• W2980218129 cites W4235857807 @default.
• W2980218129 cites W4255298747 @default.
• W2980218129 doi "https://doi.org/10.1007/978-3-030-26439-0_14" @default.
• W2980218129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31605234" @default.
• W2980218129 hasPublicationYear "2019" @default.
• W2980218129 type Work @default.
• W2980218129 sameAs 2980218129 @default.
• W2980218129 citedByCount "8" @default.
• W2980218129 countsByYear W29802181292020 @default.
• W2980218129 countsByYear W29802181292021 @default.
• W2980218129 countsByYear W29802181292023 @default.
• W2980218129 crossrefType "book-chapter" @default.
• W2980218129 hasAuthorship W2980218129A5000601939 @default.
• W2980218129 hasAuthorship W2980218129A5001410842 @default.
• W2980218129 hasAuthorship W2980218129A5083616708 @default.
• W2980218129 hasConcept C113968399 @default.
• W2980218129 hasConcept C121608353 @default.
• W2980218129 hasConcept C126322002 @default.
• W2980218129 hasConcept C142724271 @default.
• W2980218129 hasConcept C152110520 @default.
• W2980218129 hasConcept C172680121 @default.
• W2980218129 hasConcept C2775934546 @default.
• W2980218129 hasConcept C2777306565 @default.
• W2980218129 hasConcept C2778258057 @default.
• W2980218129 hasConcept C2779013556 @default.
• W2980218129 hasConcept C2779234561 @default.
• W2980218129 hasConcept C2779529041 @default.
• W2980218129 hasConcept C2779823535 @default.
• W2980218129 hasConcept C2780007613 @default.
• W2980218129 hasConcept C2781230642 @default.
• W2980218129 hasConcept C2781335228 @default.
• W2980218129 hasConcept C502942594 @default.
• W2980218129 hasConcept C51679486 @default.
• W2980218129 hasConcept C54355233 @default.
• W2980218129 hasConcept C552990157 @default.
• W2980218129 hasConcept C61238886 @default.
• W2980218129 hasConcept C70721500 @default.
• W2980218129 hasConcept C71924100 @default.
• W2980218129 hasConcept C86803240 @default.
• W2980218129 hasConceptScore W2980218129C113968399 @default.
• W2980218129 hasConceptScore W2980218129C121608353 @default.
• W2980218129 hasConceptScore W2980218129C126322002 @default.
• W2980218129 hasConceptScore W2980218129C142724271 @default.
• W2980218129 hasConceptScore W2980218129C152110520 @default.
• W2980218129 hasConceptScore W2980218129C172680121 @default.
• W2980218129 hasConceptScore W2980218129C2775934546 @default.
• W2980218129 hasConceptScore W2980218129C2777306565 @default.
• W2980218129 hasConceptScore W2980218129C2778258057 @default.
• W2980218129 hasConceptScore W2980218129C2779013556 @default.
• W2980218129 hasConceptScore W2980218129C2779234561 @default.
• W2980218129 hasConceptScore W2980218129C2779529041 @default.
• W2980218129 hasConceptScore W2980218129C2779823535 @default.
• W2980218129 hasConceptScore W2980218129C2780007613 @default.
• W2980218129 hasConceptScore W2980218129C2781230642 @default.
• W2980218129 hasConceptScore W2980218129C2781335228 @default.
• W2980218129 hasConceptScore W2980218129C502942594 @default.

• next