FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980229142> ?p ?o ?g. }

• W2980229142 endingPage "397" @default.
• W2980229142 startingPage "386" @default.
• W2980229142 abstract "Post-transcriptional regulation by miRNAs plays an important role in the pathogenesis of rheumatoid arthritis (RA), however, the roles of specific miRNAs in RA pathogenesis remain largely unclear. This study performed dual-omics (miRNA and mRNA) integration analysis and in-depth cellular and molecular functional exploration to identify novel RA-associated miRNAs and to understand their underlying pathogenic mechanism. Based on the miRNA and mRNA expression profiles in peripheral blood mononuclear cells (PBMCs) from a discovery sample set (25 RA cases and 18 healthy controls), 18 differentially expressed miRNAs (DEMIRs) (|Fold-change|>2 and P < 0.05) were identified and corresponding interaction networks of DEMIRs and mRNA were constructed. After the expression validation of the DEMIRs in a validation sample set (35 RA cases and 35 healthy controls), miR-99b-5p was highlighted. The over-expression of newly discovered miR-99b-5p is able to suppress T cell apoptosis, promote cell proliferation and activation, increase expression of proinflammatory cytokines (IL-2, IL-6, TNF-α, and IFN-γ), and inhibit expression of its target genes mTOR and RASSF4. This study comprehensively identified PBMC-expressed miRNAs along with corresponding regulatory networks significant for RA and discovered miR-99b-5p as a novel post-transcriptional mediator involved in RA pathogenesis. The findings improved our understanding of RA pathogenesis and provided novel insights into the molecular mechanisms underlying RA pathogenesis." @default.
• W2980229142 created "2019-10-18" @default.
• W2980229142 creator A5018249303 @default.
• W2980229142 creator A5025557155 @default.
• W2980229142 creator A5025808877 @default.
• W2980229142 creator A5041893821 @default.
• W2980229142 creator A5053595979 @default.
• W2980229142 creator A5056559492 @default.
• W2980229142 creator A5062251921 @default.
• W2980229142 creator A5066108947 @default.
• W2980229142 creator A5066156506 @default.
• W2980229142 creator A5069907598 @default.
• W2980229142 creator A5071531284 @default.
• W2980229142 creator A5072824384 @default.
• W2980229142 creator A5091577802 @default.
• W2980229142 date "2019-10-10" @default.
• W2980229142 modified "2023-10-08" @default.
• W2980229142 title "Identification of PBMC-expressed miRNAs for rheumatoid arthritis" @default.
• W2980229142 cites W1224580755 @default.
• W2980229142 cites W1513024220 @default.
• W2980229142 cites W1578152803 @default.
• W2980229142 cites W1917608452 @default.
• W2980229142 cites W1968142189 @default.
• W2980229142 cites W1975141727 @default.
• W2980229142 cites W1978088642 @default.
• W2980229142 cites W1979206745 @default.
• W2980229142 cites W1992141011 @default.
• W2980229142 cites W1996639668 @default.
• W2980229142 cites W1997001231 @default.
• W2980229142 cites W2025233865 @default.
• W2980229142 cites W2029415255 @default.
• W2980229142 cites W2035279761 @default.
• W2980229142 cites W2040195918 @default.
• W2980229142 cites W2052752381 @default.
• W2980229142 cites W2054117275 @default.
• W2980229142 cites W2064366944 @default.
• W2980229142 cites W2068127752 @default.
• W2980229142 cites W2071563106 @default.
• W2980229142 cites W2096115110 @default.
• W2980229142 cites W2097734060 @default.
• W2980229142 cites W2111687673 @default.
• W2980229142 cites W2117786309 @default.
• W2980229142 cites W2122624605 @default.
• W2980229142 cites W2130894316 @default.
• W2980229142 cites W2133777407 @default.
• W2980229142 cites W2142213527 @default.
• W2980229142 cites W2146024986 @default.
• W2980229142 cites W2157586673 @default.
• W2980229142 cites W2161425478 @default.
• W2980229142 cites W2172338503 @default.
• W2980229142 cites W2173293677 @default.
• W2980229142 cites W2261737322 @default.
• W2980229142 cites W2302089568 @default.
• W2980229142 cites W2520824122 @default.
• W2980229142 cites W2529902280 @default.
• W2980229142 cites W2530336006 @default.
• W2980229142 cites W2551421447 @default.
• W2980229142 cites W2616112277 @default.
• W2980229142 cites W2743646726 @default.
• W2980229142 cites W2748585716 @default.
• W2980229142 cites W2767548359 @default.
• W2980229142 cites W2772075789 @default.
• W2980229142 cites W2780724631 @default.
• W2980229142 cites W2791308648 @default.
• W2980229142 cites W2794761110 @default.
• W2980229142 cites W3139960800 @default.
• W2980229142 cites W750760073 @default.
• W2980229142 doi "https://doi.org/10.1080/15592294.2019.1676613" @default.
• W2980229142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7153549" @default.
• W2980229142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31588838" @default.
• W2980229142 hasPublicationYear "2019" @default.
• W2980229142 type Work @default.
• W2980229142 sameAs 2980229142 @default.
• W2980229142 citedByCount "15" @default.
• W2980229142 countsByYear W29802291422020 @default.
• W2980229142 countsByYear W29802291422021 @default.
• W2980229142 countsByYear W29802291422022 @default.
• W2980229142 countsByYear W29802291422023 @default.
• W2980229142 crossrefType "journal-article" @default.
• W2980229142 hasAuthorship W2980229142A5018249303 @default.
• W2980229142 hasAuthorship W2980229142A5025557155 @default.
• W2980229142 hasAuthorship W2980229142A5025808877 @default.
• W2980229142 hasAuthorship W2980229142A5041893821 @default.
• W2980229142 hasAuthorship W2980229142A5053595979 @default.
• W2980229142 hasAuthorship W2980229142A5056559492 @default.
• W2980229142 hasAuthorship W2980229142A5062251921 @default.
• W2980229142 hasAuthorship W2980229142A5066108947 @default.
• W2980229142 hasAuthorship W2980229142A5066156506 @default.
• W2980229142 hasAuthorship W2980229142A5069907598 @default.
• W2980229142 hasAuthorship W2980229142A5071531284 @default.
• W2980229142 hasAuthorship W2980229142A5072824384 @default.
• W2980229142 hasAuthorship W2980229142A5091577802 @default.
• W2980229142 hasBestOaLocation W29802291421 @default.
• W2980229142 hasConcept C104317684 @default.
• W2980229142 hasConcept C137061746 @default.
• W2980229142 hasConcept C145059251 @default.
• W2980229142 hasConcept C150194340 @default.
• W2980229142 hasConcept C164027704 @default.

• next