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• W2980252792 abstract "Abstract Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set enrichment analysis using summary statistics from a large-scale genome-wide association study (N = 13,163) of hippocampal volume from the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium and two year hippocampal volume changes from baseline in cognitively normal individuals from Alzheimer’s Disease Neuroimaging Initiative Cohort (ADNI). Gene-set enrichment analysis of hippocampal volume identified 44 significantly enriched biological pathways (FDR corrected p -value < 0.05), of which 38 pathways were related to neurogenesis-related processes including neurogenesis, generation of new neurons, neuronal development, and neuronal migration and differentiation. For genes highly represented in the significantly enriched neurogenesis-related pathways, gene-based association analysis identified TESC , ACVR1 , MSRB3 , and DPP4 as significantly associated with hippocampal volume. Furthermore, co-expression network-based functional analysis of gene expression data in the hippocampal subfields, CA1 and CA3, from 32 normal controls showed that distinct co-expression modules were mostly enriched in neurogenesis related pathways. Our results suggest that neurogenesis-related pathways may be enriched for hippocampal volume and that hippocampal volume may serve as a potential phenotype for the investigation of human adult neurogenesis." @default.
• W2980252792 created "2019-10-18" @default.
• W2980252792 creator A5035352293 @default.
• W2980252792 date "2019-10-10" @default.
• W2980252792 modified "2023-10-18" @default.
• W2980252792 title "Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways" @default.
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• W2980252792 doi "https://doi.org/10.1038/s41598-019-50507-3" @default.
• W2980252792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6787090" @default.
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