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• W2980253192 endingPage "e0215789" @default.
• W2980253192 startingPage "e0215789" @default.
• W2980253192 abstract "Mouse models of mesial temporal lobe epilepsy recapitulate aspects of human epilepsy, which is characterized by neuronal network remodeling in the hippocampal dentate gyrus. Observational studies suggest that this remodeling is associated with altered Wnt pathway signaling, although this has not been experimentally examined. We used the well-characterized mouse intrahippocampal kainate model of temporal lobe epilepsy to examine associations between hippocampal neurogenesis and altered Wnt signaling after seizure induction. Tissue was analyzed using immunohistochemistry and confocal microscopy, and gene expression analysis was performed by RT-qPCR on RNA extracted from anatomically micro-dissected dentate gyri. Seizures increased neurogenesis and dendritic arborization of newborn hippocampal dentate granule cells in peri-ictal regions, and decreased neurogenesis in the ictal zone, 2-weeks after kainate injection. Interestingly, administration of the novel canonical Wnt pathway inhibitor XAV939 daily for 2-weeks after kainate injection further increased dendritic arborization in peri-ictal regions after seizure, without an effect on baseline neurogenesis in control animals. Transcriptome analysis of dentate gyri demonstrated significant canonical Wnt gene dysregulation in kainate-injected mice across all regions for Wnt3, 5a and 9a. Intriguingly, certain Wnt genes demonstrated differential patterns of dysregulation between the ictal and peri-ictal zones, most notably Wnt5B, 7B and DKK-1. Together, these results demonstrate regional variation in Wnt pathway dysregulation early after seizure induction, and surprisingly, suggest that some Wnt-mediated effects might actually temper aberrant neurogenesis after seizures. The Wnt pathway may therefore provide suitable targets for novel therapies that prevent network remodeling and the development of epileptic foci in high-risk patients." @default.
• W2980253192 created "2019-10-18" @default.
• W2980253192 creator A5010852261 @default.
• W2980253192 creator A5050471569 @default.
• W2980253192 date "2019-10-09" @default.
• W2980253192 modified "2023-09-30" @default.
• W2980253192 title "Neuronal network remodeling and Wnt pathway dysregulation in the intra-hippocampal kainate mouse model of temporal lobe epilepsy" @default.
• W2980253192 cites W103143395 @default.
• W2980253192 cites W1487386905 @default.
• W2980253192 cites W1557124033 @default.
• W2980253192 cites W1711524127 @default.
• W2980253192 cites W1964600153 @default.
• W2980253192 cites W1969158362 @default.
• W2980253192 cites W1971228531 @default.
• W2980253192 cites W1987248191 @default.
• W2980253192 cites W1987375164 @default.
• W2980253192 cites W1999006381 @default.
• W2980253192 cites W1999508923 @default.
• W2980253192 cites W2004017387 @default.
• W2980253192 cites W2013705793 @default.
• W2980253192 cites W2014574033 @default.
• W2980253192 cites W2016443275 @default.
• W2980253192 cites W2020652391 @default.
• W2980253192 cites W2026082008 @default.
• W2980253192 cites W2029934873 @default.
• W2980253192 cites W2030091101 @default.
• W2980253192 cites W2034952028 @default.
• W2980253192 cites W2039316630 @default.
• W2980253192 cites W2040821610 @default.
• W2980253192 cites W2040905384 @default.
• W2980253192 cites W2045009795 @default.
• W2980253192 cites W2045549224 @default.
• W2980253192 cites W2047962090 @default.
• W2980253192 cites W2051064821 @default.
• W2980253192 cites W2052543845 @default.
• W2980253192 cites W2057257265 @default.
• W2980253192 cites W2063620236 @default.
• W2980253192 cites W2067128446 @default.
• W2980253192 cites W2074987637 @default.
• W2980253192 cites W2076218857 @default.
• W2980253192 cites W2078686168 @default.
• W2980253192 cites W2081752203 @default.
• W2980253192 cites W2086244825 @default.
• W2980253192 cites W2087203385 @default.
• W2980253192 cites W2088188719 @default.
• W2980253192 cites W2089204174 @default.
• W2980253192 cites W2091406481 @default.
• W2980253192 cites W2093964966 @default.
• W2980253192 cites W2101240752 @default.
• W2980253192 cites W2103946141 @default.
• W2980253192 cites W2107277218 @default.
• W2980253192 cites W2113775152 @default.
• W2980253192 cites W2119137351 @default.
• W2980253192 cites W2123002302 @default.
• W2980253192 cites W2123843070 @default.
• W2980253192 cites W2131037167 @default.
• W2980253192 cites W2135200619 @default.
• W2980253192 cites W2144060956 @default.
• W2980253192 cites W2150682032 @default.
• W2980253192 cites W2150936467 @default.
• W2980253192 cites W2151189924 @default.
• W2980253192 cites W2152826846 @default.
• W2980253192 cites W2155852776 @default.
• W2980253192 cites W2158732238 @default.
• W2980253192 cites W2165420947 @default.
• W2980253192 cites W2213122689 @default.
• W2980253192 cites W2339420972 @default.
• W2980253192 cites W2344324270 @default.
• W2980253192 cites W2417145476 @default.
• W2980253192 cites W2513094297 @default.
• W2980253192 cites W2516645296 @default.
• W2980253192 cites W2570218844 @default.
• W2980253192 cites W2582281786 @default.
• W2980253192 cites W2594931647 @default.
• W2980253192 cites W2613883024 @default.
• W2980253192 cites W2614066616 @default.
• W2980253192 cites W2734664063 @default.
• W2980253192 cites W2735080048 @default.
• W2980253192 cites W2765481101 @default.
• W2980253192 cites W2767164771 @default.
• W2980253192 cites W2792492991 @default.
• W2980253192 cites W2884025504 @default.
• W2980253192 cites W2884533127 @default.
• W2980253192 cites W2904747119 @default.
• W2980253192 cites W1964184380 @default.
• W2980253192 doi "https://doi.org/10.1371/journal.pone.0215789" @default.
• W2980253192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6785072" @default.
• W2980253192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31596871" @default.
• W2980253192 hasPublicationYear "2019" @default.
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