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• W2980262515 abstract "For HIV cure strategies like kick and kill to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some, but not all, ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and clinical models." @default.
• W2980262515 created "2019-10-18" @default.
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• W2980262515 date "2019-12-20" @default.
• W2980262515 modified "2023-09-30" @default.
• W2980262515 title "Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs" @default.
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• W2980262515 doi "https://doi.org/10.1128/aac.01639-19" @default.
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