Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980276085> ?p ?o ?g. }
Showing items 1 to 32 of
32
with 100 items per page.
- W2980276085 abstract "The vast majority of anticancer chemotherapeutic agents in clinical use have a high incidence of adverse side effects as a result of their lack of specificity towards malignant cells. The therapeutic use of these drugs is therefore limited, despite most of them having potent anti-tumour activity in vitro1. The non-specific actions can be overcome by targeting tumour cells more selectively than healthy cells and this is therefore a major challenge facing modern cancer therapy. Ideally, decreased uptake of these agents by healthy cells would not only decrease their associated toxicity, but also lower the dose required to kill the cancer cell. Current approaches to develop tumour-specific drugs are based on targeting a single deregulated pathway or an overexpressed receptor, and there are a number of molecules that successfully validate this strategy. These include monoclonal antibodies, peptides, folic acid, hormones and growth factors. Although demonstrating selective targeting is feasible, few of these agents are useful therapeutically, since most of the drugs have shown modest cell killing activity2. A valuable alternative to enhance drug specificity is to develop vector systems that have an enhanced affinity towards cancer cells. This would enable better use of already established chemotherapeutic agents as a result of preferential uptake and diminished secondary effects on healthy cells. Over the last few years, polyamine backbones have been studied as one such vector system, aiming to take advantage of the polyamine transport system (PTS) in cancer cells for selective delivery of known anticancer drugs. In this article, we describe the basic principles, as well as recent advances regarding this novel approach." @default.
- W2980276085 created "2019-10-18" @default.
- W2980276085 creator A5073305642 @default.
- W2980276085 creator A5079602229 @default.
- W2980276085 date "2012-02-01" @default.
- W2980276085 modified "2023-09-24" @default.
- W2980276085 title "Targeting tumours: Developing vector systems" @default.
- W2980276085 doi "https://doi.org/10.1042/bio03401022" @default.
- W2980276085 hasPublicationYear "2012" @default.
- W2980276085 type Work @default.
- W2980276085 sameAs 2980276085 @default.
- W2980276085 citedByCount "0" @default.
- W2980276085 crossrefType "journal-article" @default.
- W2980276085 hasAuthorship W2980276085A5073305642 @default.
- W2980276085 hasAuthorship W2980276085A5079602229 @default.
- W2980276085 hasBestOaLocation W29802760851 @default.
- W2980276085 hasConcept C41008148 @default.
- W2980276085 hasConceptScore W2980276085C41008148 @default.
- W2980276085 hasLocation W29802760851 @default.
- W2980276085 hasOpenAccess W2980276085 @default.
- W2980276085 hasPrimaryLocation W29802760851 @default.
- W2980276085 hasRelatedWork W1978403064 @default.
- W2980276085 hasRelatedWork W2081749850 @default.
- W2980276085 hasRelatedWork W2107464363 @default.
- W2980276085 hasRelatedWork W2394929721 @default.
- W2980276085 hasRelatedWork W2466284311 @default.
- W2980276085 hasRelatedWork W2977634795 @default.
- W2980276085 hasRelatedWork W2999193811 @default.
- W2980276085 isParatext "false" @default.
- W2980276085 isRetracted "false" @default.
- W2980276085 magId "2980276085" @default.
- W2980276085 workType "article" @default.