FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980278296> ?p ?o ?g. }

• W2980278296 abstract "Background: Several studies on 18F-FDG-PET/CT have investigated the prognostic role of this imaging modality in different tumors after treatment. Nevertheless, its role in restaging patients with recurrent CM still needs to be defined. Objective: The aim of this retrospective multicenter study was to evaluate the clinical and prognostic impact of 18F-FDG-PET/CT on the restaging process of cutaneous melanoma (CM) after surgery in patients with suspected distant recurrent disease or suspected metastatic progression disease. Materials and Methods: 74 patients surgically treated for CM underwent 18F-FDG-PET/CT for suspected distant recurrent disease or suspected metastatic progression disease. The diagnostic accuracy of visually interpreted 18F-FDG-PET/CT was obtained by considering histology (n=21 patients), other diagnostic imaging modalities performed within 2 months of PET/CT (CT in 52/74 patients and Whole-Body MRI in 18/74 patients) and clinical follow-up (n=74 patients) for at least 24 months containing all the clinical and diagnostic information useful for the PET performance assessment and outcome. Progression-free survival (PFS) and overall survival (OS) were assessed by using the Kaplan- Meier method. The risk of progression (Hazard Ratio-HR) was computed by the Cox regression analysis. Results: Suspicion of recurrent CM was confirmed in 24/27 patients with a positive 18F-FDG-PET/CT scan. Overall, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 18F-FDG-PET/CT were 82%, 93%, 88%, 89%, and 89%, respectively, with area under the curve being 0.87 (95%IC 0.78-0.97; p<0.05). 18F-FDG-PET/CT findings significantly influenced the therapeutic management in 18 patients (modifying therapy in 10 patients; guiding surgery in 8 patients). After 2 years of follow-up, PFS was significantly longer in patients with a negative vs. a positive 18F-FDG-PET/CT scan (90% vs 46%, p<0.05; Fig. 1). Moreover, a negative scan was associated with a significantly longer OS than a positive one (76% vs 39% after 2 years, p<0.05; Fig. 2). In addition, a positive 18F-FDG-PET/CT scan was associated with an increased risk of disease progression (HR=8.2; p0,05). Conclusion: 18F-FDG-PET/CT showed a valuable diagnostic performance in patients with suspicion of recurrent CM. This imaging modality might have an important prognostic value in predicting the survival outcomes, assessing the risk of disease progression, and guiding treatment decision making." @default.
• W2980278296 created "2019-10-18" @default.
• W2980278296 creator A5001401616 @default.
• W2980278296 creator A5004778514 @default.
• W2980278296 creator A5009393412 @default.
• W2980278296 creator A5014098310 @default.
• W2980278296 creator A5015652095 @default.
• W2980278296 creator A5020586666 @default.
• W2980278296 creator A5022259916 @default.
• W2980278296 creator A5032843032 @default.
• W2980278296 creator A5033465412 @default.
• W2980278296 creator A5041824973 @default.
• W2980278296 creator A5048534046 @default.
• W2980278296 creator A5070638674 @default.
• W2980278296 creator A5081353003 @default.
• W2980278296 date "2020-03-13" @default.
• W2980278296 modified "2023-09-23" @default.
• W2980278296 title "Clinical and Prognostic Value of 18F-FDG-PET/CT in the Restaging Process of Recurrent Cutaneous Melanoma" @default.
• W2980278296 cites W1818465258 @default.
• W2980278296 cites W1967726959 @default.
• W2980278296 cites W2012173077 @default.
• W2980278296 cites W2074757843 @default.
• W2980278296 cites W2139283915 @default.
• W2980278296 cites W2141809582 @default.
• W2980278296 cites W2145938281 @default.
• W2980278296 cites W2151714455 @default.
• W2980278296 cites W2167835377 @default.
• W2980278296 cites W2235523093 @default.
• W2980278296 cites W2472818048 @default.
• W2980278296 cites W2508716926 @default.
• W2980278296 cites W2512683441 @default.
• W2980278296 cites W2548699789 @default.
• W2980278296 cites W2579771302 @default.
• W2980278296 cites W2742300299 @default.
• W2980278296 cites W2745823854 @default.
• W2980278296 cites W2763398173 @default.
• W2980278296 cites W2800745461 @default.
• W2980278296 cites W2802901538 @default.
• W2980278296 cites W2802941743 @default.
• W2980278296 cites W2805278470 @default.
• W2980278296 cites W2809784788 @default.
• W2980278296 cites W2886682433 @default.
• W2980278296 cites W2804643719 @default.
• W2980278296 doi "https://doi.org/10.2174/1874471012666191009161826" @default.
• W2980278296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31595860" @default.
• W2980278296 hasPublicationYear "2020" @default.
• W2980278296 type Work @default.
• W2980278296 sameAs 2980278296 @default.
• W2980278296 citedByCount "4" @default.
• W2980278296 countsByYear W29802782962020 @default.
• W2980278296 countsByYear W29802782962022 @default.
• W2980278296 crossrefType "journal-article" @default.
• W2980278296 hasAuthorship W2980278296A5001401616 @default.
• W2980278296 hasAuthorship W2980278296A5004778514 @default.
• W2980278296 hasAuthorship W2980278296A5009393412 @default.
• W2980278296 hasAuthorship W2980278296A5014098310 @default.
• W2980278296 hasAuthorship W2980278296A5015652095 @default.
• W2980278296 hasAuthorship W2980278296A5020586666 @default.
• W2980278296 hasAuthorship W2980278296A5022259916 @default.
• W2980278296 hasAuthorship W2980278296A5032843032 @default.
• W2980278296 hasAuthorship W2980278296A5033465412 @default.
• W2980278296 hasAuthorship W2980278296A5041824973 @default.
• W2980278296 hasAuthorship W2980278296A5048534046 @default.
• W2980278296 hasAuthorship W2980278296A5070638674 @default.
• W2980278296 hasAuthorship W2980278296A5081353003 @default.
• W2980278296 hasConcept C126322002 @default.
• W2980278296 hasConcept C126838900 @default.
• W2980278296 hasConcept C127077266 @default.
• W2980278296 hasConcept C167135981 @default.
• W2980278296 hasConcept C207103383 @default.
• W2980278296 hasConcept C2775842073 @default.
• W2980278296 hasConcept C2777658100 @default.
• W2980278296 hasConcept C2989005 @default.
• W2980278296 hasConcept C3019719930 @default.
• W2980278296 hasConcept C44249647 @default.
• W2980278296 hasConcept C502942594 @default.
• W2980278296 hasConcept C50382708 @default.
• W2980278296 hasConcept C71924100 @default.
• W2980278296 hasConceptScore W2980278296C126322002 @default.
• W2980278296 hasConceptScore W2980278296C126838900 @default.
• W2980278296 hasConceptScore W2980278296C127077266 @default.
• W2980278296 hasConceptScore W2980278296C167135981 @default.
• W2980278296 hasConceptScore W2980278296C207103383 @default.
• W2980278296 hasConceptScore W2980278296C2775842073 @default.
• W2980278296 hasConceptScore W2980278296C2777658100 @default.
• W2980278296 hasConceptScore W2980278296C2989005 @default.
• W2980278296 hasConceptScore W2980278296C3019719930 @default.
• W2980278296 hasConceptScore W2980278296C44249647 @default.
• W2980278296 hasConceptScore W2980278296C502942594 @default.
• W2980278296 hasConceptScore W2980278296C50382708 @default.
• W2980278296 hasConceptScore W2980278296C71924100 @default.
• W2980278296 hasLocation W29802782961 @default.
• W2980278296 hasLocation W29802782962 @default.
• W2980278296 hasOpenAccess W2980278296 @default.
• W2980278296 hasPrimaryLocation W29802782961 @default.
• W2980278296 hasRelatedWork W1997539222 @default.
• W2980278296 hasRelatedWork W2010959245 @default.
• W2980278296 hasRelatedWork W2244776017 @default.
• W2980278296 hasRelatedWork W2765304038 @default.
• W2980278296 hasRelatedWork W2942312716 @default.

• next