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• W2980286516 abstract "// Flavia Alejandra Bruna 1 , 2 , 7 , Leonardo Rafael Romeo 1 , 3 , Fiorella Campo-Verde-Arbocco 1 , David Contador 2 , Silvina G&#x00F3;mez 1 , Flavia Santiano 1 , Corina Ver&#x00F3;nica Sasso 1 , Leila Zyla 1 , Constanza L&#x00F3;pez-Fontana 1 , Juan Carlos Calvo 4 , 5 , Rub&#x00E9;n Walter Car&#x00F3;n 1 and Virginia Pistone-Creydt 1 , 6 1 Instituto de Medicina y Biolog&#x00ED;a Experimental de Cuyo (IMBECU), Centro Cient&#x00ED;fico y Tecnol&#x00F3;gico Mendoza, Consejo Nacional de Investigaciones Cient&#x00ED;ficas y T&#x00E9;cnicas (CONICET), Mendoza, Argentina 2 Centro de Medicina Regenerativa, Facultad de Medicina, Cl&#x00ED;nica Alemana, Universidad del Desarrollo, Santiago, Chile 3 Departamento de Urolog&#x00ED;a y Transplante Renal, Hospital Espa&#x00F1;ol de Mendoza, Mendoza, Argentina 4 Instituto de Biolog&#x00ED;a y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Cient&#x00ED;ficas y T&#x00E9;cnicas (CONICET), Buenos Aires, Argentina 5 Departamento de Qu&#x00ED;mica Biol&#x00F3;gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina 6 Universidad Nacional de Cuyo, Facultad de Ciencias M&#x00E9;dicas, Departamento de Fisiolog&#x00ED;a, Mendoza, Argentina 7 Universidad Nacional de Cuyo, Facultad de Odontolog&#x00ED;a, Mendoza, Argentina Correspondence to: Virginia Pistone-Creydt, email: vpistone@mendoza-conicet.gob.ar Keywords: human renal adipose tissue; renal epithelial cells; cancer; epithelial-stromal interactions; migration Received: February 07, 2019     Accepted: July 29, 2019     Published: September 10, 2019 ABSTRACT Tumor cells can interact with neighboring adipose tissue. We evaluated components present in human adipose explants from normal (hRAN) and kidney cancer (hRAT) tissue, and we evaluated the effects of conditioned media (CMs) from hRAN and hRAT on proliferation, adhesion and migration of tumor and non-tumor human renal epithelial cell lines. In addition, we evaluated the expression of AdipoR1, ObR, CD44, vimentin, pERK and pPI3K on cell lines incubated with CMs. hRAN were obtained from healthy operated donors, and hRAT from patients who underwent a nephrectomy. hRAT showed increased levels of versican, leptin and ObR; and decreased levels of perilipin, adiponectin and AdipoR1, compared to hRAN. Cell lines showed a significant decrease in cell adhesion and increase in cell migration after incubation with hRAT-CMs vs. hRAN- or control-CMs. Surprisingly, HK-2, 786-O and ACHN cells showed a significant decrease in cell migration after incubation with hRAN-CMs vs. control-CMs. No difference in proliferation of cell lines was found after 24 or 48 h of treatment with CMs. AdipoR1 in ACHN and Caki-1 cells decreased significantly after incubation with hRAT-CMs vs. hRAN-CMs and control-CMs. ObR and CD44 increased in tumor line cells, and vimentin increased in non-tumor cells, after incubation with hRAT-CMs vs. hRAN-CMs and control-CMs. We observed an increase in the expression of pERK and pPI3K in HK-2, 786-O and ACHN, incubated with hRAT-CMs. In conclusion, results showed that adipose microenvironment can regulate the behavior of tumor and non tumor human renal epithelial cells." @default.
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• W2980286516 date "2019-09-10" @default.
• W2980286516 modified "2023-10-08" @default.
• W2980286516 title "Human renal adipose tissue from normal and tumor kidney: its influence on renal cell carcinoma" @default.
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• W2980286516 doi "https://doi.org/10.18632/oncotarget.27157" @default.
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