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- W2980300727 abstract "The cerebellum has a parasagittal modular architecture characterized by precisely organized climbing fiber (CF) projections that are congruent with alternating aldolase C/zebrin II expression. However, the behavioral relevance of CF inputs into individual modules remains poorly understood. Here, we used two-photon calcium imaging in the cerebellar hemisphere Crus II in mice performing an auditory go/no-go task to investigate the functional differences in CF inputs to modules. CF signals in medial modules show anticipatory decreases, early increases, secondary increases, and reward-related increases or decreases, which represent quick motor initiation, go cues, fast motor behavior, and positive reward outcomes. CF signals in lateral modules show early increases and reward-related decreases, which represent no-go and/or go cues and positive reward outcomes. The boundaries of CF functions broadly correspond to those of aldolase C patterning. These results indicate that spatially segregated CF inputs in different modules play distinct roles in the execution of goal-directed behavior." @default.
- W2980300727 created "2019-10-18" @default.
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- W2980300727 date "2019-10-09" @default.
- W2980300727 modified "2023-10-06" @default.
- W2980300727 title "Modular organization of cerebellar climbing fiber inputs during goal-directed behavior" @default.
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- W2980300727 doi "https://doi.org/10.7554/elife.47021" @default.
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