Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980300989> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W2980300989 abstract "Abstract B2GPI is the major antigen for pathogenic antibodies in antiphospholipid syndrome (APS). The presence of anti-b2GPI antibodies correlates with increased risk for thrombosis and pregnancy loss in patients with APS. In animal models of thrombosis, anti-b2GPI antibodies cause the increase in thrombus size after injury to the vessel wall. We engineered a molecule, A1-A1, that prevents the binding of b2GPI to anionic phospholipids and ApoER2, and studied how it inhibits prothrombotic properties of anti-b2GPI antibodies in vivo using the laser-induced arterial thrombosis model. Lupus-prone (NZWxBXSB)F1 male mice express chronic autoimmune anti-b2GPI antibodies. In (NZWxBXSB)F1 mice, infusion of A1-A1 at a dose of 4 ug/g of body weight caused a decrease in thrombus size of more than 85% as compared to thrombus size in the absence of A1-A1. Similarly, A1-A1 inhibits prothrombotic properties of b2GPI/anti-b2GPI antibody complexes in wild type mice following acute infusion with anti-b2GPI positive APS IgG. The thrombus reduction was due to the binding of A1-A1 to b2GPI, because infusion of LA6, a structural homologue of A1 that does not bind b2GPI, did not affect thrombus size. We did not observe thrombus inhibition by A1-A1 in the absence of anti-b2GPI antibodies, indicating that A1-A1 does not affect normal thrombus formation in the absence of anti-b2GPI antibodies. Disclosures: No relevant conflicts of interest to declare." @default.
- W2980300989 created "2019-10-18" @default.
- W2980300989 creator A5023540480 @default.
- W2980300989 creator A5065189960 @default.
- W2980300989 date "2013-11-15" @default.
- W2980300989 modified "2023-09-27" @default.
- W2980300989 title "Inhibition Of Anti-b2GPI-Dependent Thrombus Enhancement In The Laser-Induced Thrombosis Model In Mice" @default.
- W2980300989 doi "https://doi.org/10.1182/blood.v122.21.1099.1099" @default.
- W2980300989 hasPublicationYear "2013" @default.
- W2980300989 type Work @default.
- W2980300989 sameAs 2980300989 @default.
- W2980300989 citedByCount "0" @default.
- W2980300989 crossrefType "journal-article" @default.
- W2980300989 hasAuthorship W2980300989A5023540480 @default.
- W2980300989 hasAuthorship W2980300989A5065189960 @default.
- W2980300989 hasConcept C126322002 @default.
- W2980300989 hasConcept C159654299 @default.
- W2980300989 hasConcept C203014093 @default.
- W2980300989 hasConcept C2780868729 @default.
- W2980300989 hasConcept C2781362458 @default.
- W2980300989 hasConcept C71924100 @default.
- W2980300989 hasConcept C98274493 @default.
- W2980300989 hasConceptScore W2980300989C126322002 @default.
- W2980300989 hasConceptScore W2980300989C159654299 @default.
- W2980300989 hasConceptScore W2980300989C203014093 @default.
- W2980300989 hasConceptScore W2980300989C2780868729 @default.
- W2980300989 hasConceptScore W2980300989C2781362458 @default.
- W2980300989 hasConceptScore W2980300989C71924100 @default.
- W2980300989 hasConceptScore W2980300989C98274493 @default.
- W2980300989 hasLocation W29803009891 @default.
- W2980300989 hasOpenAccess W2980300989 @default.
- W2980300989 hasPrimaryLocation W29803009891 @default.
- W2980300989 hasRelatedWork W1974727307 @default.
- W2980300989 hasRelatedWork W1986703193 @default.
- W2980300989 hasRelatedWork W1989836808 @default.
- W2980300989 hasRelatedWork W1992492269 @default.
- W2980300989 hasRelatedWork W2004045151 @default.
- W2980300989 hasRelatedWork W2005844105 @default.
- W2980300989 hasRelatedWork W2078927142 @default.
- W2980300989 hasRelatedWork W2135784803 @default.
- W2980300989 hasRelatedWork W2409418092 @default.
- W2980300989 hasRelatedWork W2472727793 @default.
- W2980300989 hasRelatedWork W2558105731 @default.
- W2980300989 hasRelatedWork W2620661709 @default.
- W2980300989 hasRelatedWork W2789595877 @default.
- W2980300989 hasRelatedWork W2802655852 @default.
- W2980300989 hasRelatedWork W2807450139 @default.
- W2980300989 hasRelatedWork W2904196593 @default.
- W2980300989 hasRelatedWork W2919449835 @default.
- W2980300989 hasRelatedWork W3094736105 @default.
- W2980300989 hasRelatedWork W3213678197 @default.
- W2980300989 hasRelatedWork W70106244 @default.
- W2980300989 isParatext "false" @default.
- W2980300989 isRetracted "false" @default.
- W2980300989 magId "2980300989" @default.
- W2980300989 workType "article" @default.