FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980321746> ?p ?o ?g. }

• W2980321746 endingPage "100983" @default.
• W2980321746 startingPage "100983" @default.
• W2980321746 abstract "The inflammatory response is a highly regulated process, and its dysregulation can lead to the establishment of chronic inflammation and in some cases, to death. Diterpenoids have found to be an important class of phytochemicals possessing anti-inflammatory potential. In present study, some Labdane diterpenoids isolated from Andrographis paniculata like, Andrographolide (compound A); 14-deoxy-11,12-didehydroandrographolide (compound B); 14-Deoxyandrographolide (compound C) and 3,14- Dideoxyandrographolide (compound D) were evaluated for their cyclooxygenase inhibitory, antioxidant and anti-proliferative activity using different cancer cell lines. The results obtained revealed that compound C has maximum inhibitory potential towards COX-2 (83.24%; IC50 9.0 μg/ml). The docking data was found to be in accordance with the in vitro experimental results, with compound C demonstrating the promising binding free energy (-8.1 Kcal/mol). The anti-proliferative data showed that all compounds had significant cytotoxicity towards selected (HCT-15, INT- 407 and HeLa-B75) cancer cell lines, while compounds also demonstrated effective antioxidant potential. The antioxidant profile reveals that, the compound C possess most promising SOR scavenging activity (91.41 ± 1.56%), while the lowest activity was recorded from compound D (16.30 ± 0.25). The results obtained by in silico molecular docking study are in accordance with the in vitro activities. The isolated compounds showing promising anti-inflammatory and antiproliferative activity could be considered for acceleration in research for development of diterpenoids based anti-inflammatory agents." @default.
• W2980321746 created "2019-10-25" @default.
• W2980321746 creator A5020767769 @default.
• W2980321746 creator A5031720406 @default.
• W2980321746 creator A5074898295 @default.
• W2980321746 date "2019-12-01" @default.
• W2980321746 modified "2023-10-18" @default.
• W2980321746 title "An investigation on in vitro anti-inflammatory and antiproliferative potential of isolated Labdane diterpenoids from Andrographis paniculata (Burm. f.) wall. Ex nees: An important medicinal plant prescribed in Ayurveda" @default.
• W2980321746 cites W1494920110 @default.
• W2980321746 cites W1968918185 @default.
• W2980321746 cites W1982480135 @default.
• W2980321746 cites W1983798934 @default.
• W2980321746 cites W1987147444 @default.
• W2980321746 cites W1991800232 @default.
• W2980321746 cites W1997850959 @default.
• W2980321746 cites W1998599343 @default.
• W2980321746 cites W2003709875 @default.
• W2980321746 cites W2011199617 @default.
• W2980321746 cites W2019018257 @default.
• W2980321746 cites W2023284204 @default.
• W2980321746 cites W2026541112 @default.
• W2980321746 cites W2030608460 @default.
• W2980321746 cites W2039619503 @default.
• W2980321746 cites W2046810003 @default.
• W2980321746 cites W2066713292 @default.
• W2980321746 cites W2066920929 @default.
• W2980321746 cites W2070259487 @default.
• W2980321746 cites W2070503345 @default.
• W2980321746 cites W2072639113 @default.
• W2980321746 cites W2073427845 @default.
• W2980321746 cites W2073907979 @default.
• W2980321746 cites W2074473216 @default.
• W2980321746 cites W2075318448 @default.
• W2980321746 cites W2081912151 @default.
• W2980321746 cites W2097997344 @default.
• W2980321746 cites W2100125011 @default.
• W2980321746 cites W2109370496 @default.
• W2980321746 cites W2126853519 @default.
• W2980321746 cites W2130479394 @default.
• W2980321746 cites W2133043485 @default.
• W2980321746 cites W2158534713 @default.
• W2980321746 cites W2162822931 @default.
• W2980321746 cites W2163756514 @default.
• W2980321746 cites W2165526004 @default.
• W2980321746 cites W2192858430 @default.
• W2980321746 cites W2921291045 @default.
• W2980321746 cites W2922852165 @default.
• W2980321746 cites W2961436801 @default.
• W2980321746 cites W1980489241 @default.
• W2980321746 doi "https://doi.org/10.1016/j.eujim.2019.100983" @default.
• W2980321746 hasPublicationYear "2019" @default.
• W2980321746 type Work @default.
• W2980321746 sameAs 2980321746 @default.
• W2980321746 citedByCount "2" @default.
• W2980321746 countsByYear W29803217462021 @default.
• W2980321746 crossrefType "journal-article" @default.
• W2980321746 hasAuthorship W2980321746A5020767769 @default.
• W2980321746 hasAuthorship W2980321746A5031720406 @default.
• W2980321746 hasAuthorship W2980321746A5074898295 @default.
• W2980321746 hasConcept C109316439 @default.
• W2980321746 hasConcept C142724271 @default.
• W2980321746 hasConcept C159110408 @default.
• W2980321746 hasConcept C185592680 @default.
• W2980321746 hasConcept C202751555 @default.
• W2980321746 hasConcept C204787440 @default.
• W2980321746 hasConcept C2776710815 @default.
• W2980321746 hasConcept C2777366897 @default.
• W2980321746 hasConcept C2777970627 @default.
• W2980321746 hasConcept C2778004101 @default.
• W2980321746 hasConcept C2778594897 @default.
• W2980321746 hasConcept C2779311684 @default.
• W2980321746 hasConcept C2779703632 @default.
• W2980321746 hasConcept C2781357234 @default.
• W2980321746 hasConcept C41685203 @default.
• W2980321746 hasConcept C55493867 @default.
• W2980321746 hasConcept C556039675 @default.
• W2980321746 hasConcept C71240020 @default.
• W2980321746 hasConcept C71924100 @default.
• W2980321746 hasConcept C86803240 @default.
• W2980321746 hasConcept C98274493 @default.
• W2980321746 hasConceptScore W2980321746C109316439 @default.
• W2980321746 hasConceptScore W2980321746C142724271 @default.
• W2980321746 hasConceptScore W2980321746C159110408 @default.
• W2980321746 hasConceptScore W2980321746C185592680 @default.
• W2980321746 hasConceptScore W2980321746C202751555 @default.
• W2980321746 hasConceptScore W2980321746C204787440 @default.
• W2980321746 hasConceptScore W2980321746C2776710815 @default.
• W2980321746 hasConceptScore W2980321746C2777366897 @default.
• W2980321746 hasConceptScore W2980321746C2777970627 @default.
• W2980321746 hasConceptScore W2980321746C2778004101 @default.
• W2980321746 hasConceptScore W2980321746C2778594897 @default.
• W2980321746 hasConceptScore W2980321746C2779311684 @default.
• W2980321746 hasConceptScore W2980321746C2779703632 @default.
• W2980321746 hasConceptScore W2980321746C2781357234 @default.
• W2980321746 hasConceptScore W2980321746C41685203 @default.
• W2980321746 hasConceptScore W2980321746C55493867 @default.
• W2980321746 hasConceptScore W2980321746C556039675 @default.
• W2980321746 hasConceptScore W2980321746C71240020 @default.

• next