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- W2980322588 abstract "Abstract Our behaviour is shaped by its consequences – we seek rewards and avoid harm. It has been reported that individuals vary markedly in their avoidance of detrimental consequences, i.e. in their sensitivity to punishment. The underpinnings of this variability are poorly understood; they may be driven by differences in aversion sensitivity, motivation for reward, and/or instrumental control. We examined these hypotheses by applying several analysis strategies to the behaviour of rats ( n = 48; 18 female) trained in a task permitting concurrent assessment of punishment, reward-seeking, and Pavlovian fear. We show that punishment insensitivity is a unique phenotype, unrelated to differences in reward-seeking and Pavlovian fear, and due to a failure of instrumental control. Subjects insensitive to punishment are afraid of aversive events, they are simply unable to change their behaviour to avoid them." @default.
- W2980322588 created "2019-10-25" @default.
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- W2980322588 date "2019-10-17" @default.
- W2980322588 modified "2023-10-16" @default.
- W2980322588 title "Punishment insensitivity emerges from impaired contingency detection, not aversion insensitivity or reward dominance" @default.
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- W2980322588 doi "https://doi.org/10.1101/808873" @default.
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