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- W2980334155 abstract "Introduction Acute intestinal infections have occupied a leading place in the infectious pathology in children so far. The condition of intestinal microbiocenosis is one of the factors that determine the severity of intestinal infection, its duration, the outcome and the timing of rehabilitation from the pathogen. One of the very promising techniques for evaluating intestinal microflora in health and disease is the determination of the metabolic activity of the intestinal microflora from the spectrum of short-chain fatty acids (SCFAs). In various diseases of the gastrointestinal tract, including viral diarrhea, the process of formation, absorption and utilization of SCFAs is disrupted, so their concentrations in feces change. The aim of our research was to specify the content and profile of metabolites of the normal intestinal microflora, as well as to scrutinize their diagnostic and prognostic significance for assessing the severity of rotavirus infection in infants. Methods We examined 64 infants with rotavirus infection who were hospitalized in the Pediatrics Research Institute. The presence of rotavirus in feces was confirmed by the method of immune enzyme analysis ELISA. 30 healthy children were in the control group. The evaluation of the levels of (SCFAs) and their overall level was carried out by using the method of gas-liquid chromatography. Results In the acute period of rotavirus infection, there was a significant decrease in the content of acetic [2.478 ± 0.05 mg/ml, p Conclusion Our studies have shown that the determination of the metabolic activity of intestinal microflora from the levels and spectra of SCFAs is important for the assessment of microecological bowel disorders in infants with viral diarrhea which can serve as an additional prognostic and diagnostic criterion for the severity of the course of the disease." @default.
- W2980334155 created "2019-10-25" @default.
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- W2980334155 date "2019-06-01" @default.
- W2980334155 modified "2023-09-27" @default.
- W2980334155 title "GP185 The diagnostic and prognostic value of the short-chain fatty acids in rotavirus diarrheas in infants" @default.
- W2980334155 doi "https://doi.org/10.1136/archdischild-2019-epa.246" @default.
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