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• W2980345242 abstract "Aim It is challenging to evaluate reproductive potential during childhood. These challenges necessitate the use of invasive dynamic tests. Although the anti‐Mullerian hormone (AMH) is a reliable biomarker in evaluating testicular function, especially in the pre‐pubertal period, there are uncertainties concerning its use in a clinical setting. This study is focused on comparing the AMH and human chorionic gonadotropin (hCG) test in boys with hypogonadism. Methods A total of 160 boys aged between 0 and 18 years who presented with complaints associated with hypogonadism were prospectively enrolled in the study. All children were assigned to the following five groups: gonadal disorders ( n = 34), androgen synthesis and end organ effect disorder ( n = 48), isolated genital malformation disorders ( n = 57), hypogonadotropic hypogonadism ( n = 15) and constitutional delayed puberty ( n = 6). All children underwent a short 3‐day hCG test (1500 U/m 2 /day). The concordance and correlation were evaluated between the hCG test and AMH. Results All groups exhibited a strong correlation ( r 160 = 0.689) and strong concordance (Kappa coefficient 160 = 0.7) between the AMH and hCG test. Values of AMH higher than 32.7 pmol/L and hCG responses higher than 86 pmol/L were significant as indicative markers of functional testicular tissue presence. Conclusions This study has shown that there is a strong correlation between the AMH and short‐term hCG test and that values of AMH higher than 32.7 pmol/L and stimulated testosterone higher than 86 pmol/L can be used as indicators of functionally sufficient testicular tissue. These results indicate that AMH value can be used as a reliable and useful biomarker in the evaluation of the testicular function in 46 XY hypogonadism." @default.
• W2980345242 created "2019-10-25" @default.
• W2980345242 creator A5075718214 @default.
• W2980345242 date "2019-10-15" @default.
• W2980345242 modified "2023-09-27" @default.
• W2980345242 title "Correlation of anti‐Mullerian hormone with humanchorionic gonadotropin test in the evaluation of testicular function of children with 46 XY male hypogonadism: Use of anti‐Mullerian hormone as abiomarker" @default.
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• W2980345242 doi "https://doi.org/10.1111/jpc.14643" @default.
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