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- W2980347658 abstract "Cancer remains one of the leading causes of death worldwide. Conventional therapeutic strategies usually offer limited specificity, resulting in severe side effects and toxicity to normal tissues. Targeted cancer therapy, on the other hand, can improve the therapeutic potential of anti-cancer agents and decrease unwanted side effects. Targeted applications of cytolethal bacterial toxins have been found to be especially useful for the specific eradication of cancer cells. Targeting is either mediated by peptides or by protein-targeting moieties, such as antibodies, antibody fragments, cell-penetrating peptides (CPPs), growth factors, or cytokines. Together with a toxin domain, these molecules are more commonly referred to as immunotoxins. Targeting can also be achieved through gene delivery and cell-specific expression of a toxin. Of the available cytolethal toxins, diphtheria toxin (DT) is one of the most frequently used for these strategies. Of the many DT-based therapeutic strategies investigated to date, two immunotoxins, OntakTM and TagraxofuspTM, have gained FDA approval for clinical application. Despite some success with immunotoxins, suicide-gene therapy strategies, whereby controlled tumor-specific expression of DT is used for the eradication of malignant cells, are gaining prominence. The first part of this review focuses on DT-based immunotoxins, and it then discusses recent developments in tumor-specific expression of DT." @default.
- W2980347658 created "2019-10-25" @default.
- W2980347658 creator A5023781129 @default.
- W2980347658 creator A5061744331 @default.
- W2980347658 creator A5082198631 @default.
- W2980347658 date "2019-10-18" @default.
- W2980347658 modified "2023-10-18" @default.
- W2980347658 title "Targeted Diphtheria Toxin-Based Therapy: A Review Article" @default.
- W2980347658 cites W116741446 @default.
- W2980347658 cites W120152197 @default.
- W2980347658 cites W124601896 @default.
- W2980347658 cites W135338193 @default.
- W2980347658 cites W1493771451 @default.
- W2980347658 cites W1501842015 @default.
- W2980347658 cites W1516277032 @default.
- W2980347658 cites W1517716046 @default.
- W2980347658 cites W1527910349 @default.
- W2980347658 cites W1531134906 @default.
- W2980347658 cites W1534592663 @default.
- W2980347658 cites W1534691359 @default.
- W2980347658 cites W1536306303 @default.
- W2980347658 cites W1539969696 @default.
- W2980347658 cites W1541033317 @default.
- W2980347658 cites W154358934 @default.
- W2980347658 cites W1544416678 @default.
- W2980347658 cites W1571012244 @default.
- W2980347658 cites W1587863277 @default.
- W2980347658 cites W1588873317 @default.
- W2980347658 cites W1593005511 @default.
- W2980347658 cites W1646228632 @default.
- W2980347658 cites W1791836312 @default.
- W2980347658 cites W1795529600 @default.
- W2980347658 cites W1822949416 @default.
- W2980347658 cites W1895474562 @default.
- W2980347658 cites W1914044259 @default.
- W2980347658 cites W1917619044 @default.
- W2980347658 cites W1929606806 @default.
- W2980347658 cites W1950588385 @default.
- W2980347658 cites W1963726513 @default.
- W2980347658 cites W1964546894 @default.
- W2980347658 cites W1967073350 @default.
- W2980347658 cites W1971334971 @default.
- W2980347658 cites W1973948008 @default.
- W2980347658 cites W1975163469 @default.
- W2980347658 cites W1976437285 @default.
- W2980347658 cites W1977609480 @default.
- W2980347658 cites W1978240510 @default.
- W2980347658 cites W1978972286 @default.
- W2980347658 cites W1979327226 @default.
- W2980347658 cites W1980910331 @default.
- W2980347658 cites W1981859242 @default.
- W2980347658 cites W1981871099 @default.
- W2980347658 cites W1983553062 @default.
- W2980347658 cites W1983919470 @default.
- W2980347658 cites W1984198105 @default.
- W2980347658 cites W1987827326 @default.
- W2980347658 cites W1988166707 @default.
- W2980347658 cites W1989269073 @default.
- W2980347658 cites W1989922145 @default.
- W2980347658 cites W1990563353 @default.
- W2980347658 cites W1991485947 @default.
- W2980347658 cites W1994138031 @default.
- W2980347658 cites W1997390675 @default.
- W2980347658 cites W2001663882 @default.
- W2980347658 cites W2003811964 @default.
- W2980347658 cites W2004618110 @default.
- W2980347658 cites W2004635420 @default.
- W2980347658 cites W2009296736 @default.
- W2980347658 cites W2010305809 @default.
- W2980347658 cites W2012396846 @default.
- W2980347658 cites W2012502190 @default.
- W2980347658 cites W2013722500 @default.
- W2980347658 cites W2015573790 @default.
- W2980347658 cites W2018658367 @default.
- W2980347658 cites W2018927746 @default.
- W2980347658 cites W2020853616 @default.
- W2980347658 cites W2020873726 @default.
- W2980347658 cites W2023664605 @default.
- W2980347658 cites W2026623183 @default.
- W2980347658 cites W2027278953 @default.
- W2980347658 cites W2027437657 @default.
- W2980347658 cites W2027531502 @default.
- W2980347658 cites W2027812158 @default.
- W2980347658 cites W2029842376 @default.
- W2980347658 cites W2033206993 @default.
- W2980347658 cites W2034015894 @default.
- W2980347658 cites W2034637992 @default.
- W2980347658 cites W2035247318 @default.
- W2980347658 cites W2035523654 @default.
- W2980347658 cites W2036659547 @default.
- W2980347658 cites W2037580616 @default.
- W2980347658 cites W2038426832 @default.
- W2980347658 cites W2039981728 @default.
- W2980347658 cites W2041003006 @default.
- W2980347658 cites W2041056208 @default.
- W2980347658 cites W2041700684 @default.
- W2980347658 cites W2043006112 @default.
- W2980347658 cites W2043732412 @default.
- W2980347658 cites W2043869761 @default.
- W2980347658 cites W2044142547 @default.