FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980367074> ?p ?o ?g. }

• W2980367074 abstract "Emerging epidemiologic and neurotoxicological data suggest PM2.5 (particulate matter with aerodynamic diameter <2.5 μm) as a novel environmental risk factor for Alzheimer's disease and related dementias (ADRD), which may disproportionately affect socially disadvantaged individuals (e.g., less educated). Cognitive reserve (CR) may explain discrepancies between severity of neuropathology and cognitive performance. We prospectively investigated whether a statistically-defined measure of CR modifies the association of PM2.5 on ADRD incidence. Subjects were community-dwelling Women's Health Initiative Memory Study participants, ages 65–79 years at baseline and free of dementia at enrollment. Incident centrally-adjudicated (DSM-IV criteria) ADRD was based on annual (1996-2010) cognitive screening, neuropsychiatric evaluation, and clinical data. Three-year moving average PM2.5 residential exposures were aggregated from daily 1999–2010 estimates from nationwide spatiotemporal modeling, integrating local monitoring and atmospheric air predictions. CR was derived via a structural equation model following a Multiple Indicator, Multiple Cause framework, with cognitive scores and educational attainment as reflective indicators and physical activity and occupational attainment as formative latent variables of CR. We examined whether the resulting CR measure (median-split) modified ADRD risk associated with residing in locations exceeding the US National Ambient Air Quality Standard (3-year average PM2.5 >12 vs. ≤12 μg/m3), adjusting for potential confounders, with proportional hazards regression. Among 6113 women, 262 were classified as incident cases of ADRD (average follow-up 8.8 years). Residing in locations with high PM2.5 was associated with increased ADRD risk (hazard ratio [HR]=1.70; 95% CI [1.31, 2.22]), adjusting for geographic region, age, socioeconomic characteristics, lifestyle, clinical characteristics, and hormone therapy. This putative neurotoxic effect of PM2.5 was much greater (interaction p=0.01) among older women with lower educational attainment (≤ high school; HR=2.58, [1.66, 4.02]) compared to their counterparts (> high school; HR=1.35; [0.99, 1.85]). Although non-significant, low CR was associated with increased ADRD risk (HR=1.23; [0.90, 1.68]). The adverse effect of PM2.5 was much greater (interaction p=0.02) among women with low CR (HR=2.13; [1.51, 2.99]) than among women with high CR where the association was no longer significant (HR=1.21; [0.82, 1.78]). Our novel findings support the hypothesis that high CR attenuates the PM2.5 neurotoxicity on brain aging." @default.
• W2980367074 created "2019-10-25" @default.
• W2980367074 creator A5003112344 @default.
• W2980367074 creator A5012817292 @default.
• W2980367074 creator A5018041284 @default.
• W2980367074 creator A5026305547 @default.
• W2980367074 creator A5032500671 @default.
• W2980367074 creator A5032986788 @default.
• W2980367074 creator A5049411008 @default.
• W2980367074 creator A5050410187 @default.
• W2980367074 creator A5053375903 @default.
• W2980367074 creator A5055256446 @default.
• W2980367074 creator A5057988422 @default.
• W2980367074 creator A5062691878 @default.
• W2980367074 creator A5063225225 @default.
• W2980367074 creator A5063732312 @default.
• W2980367074 creator A5067354051 @default.
• W2980367074 creator A5072383371 @default.
• W2980367074 creator A5086664554 @default.
• W2980367074 date "2019-07-01" @default.
• W2980367074 modified "2023-09-27" @default.
• W2980367074 title "P2-555: HETEROGENEITY IN THE INCREASED RISK FOR ALZHEIMER'S DISEASE AND RELATED DEMENTIAS ASSOCIATED WITH FINE PARTICLE EXPOSURE: EXPLORING THE ROLE OF COGNITIVE RESERVE" @default.
• W2980367074 doi "https://doi.org/10.1016/j.jalz.2019.06.2964" @default.
• W2980367074 hasPublicationYear "2019" @default.
• W2980367074 type Work @default.
• W2980367074 sameAs 2980367074 @default.
• W2980367074 citedByCount "0" @default.
• W2980367074 crossrefType "journal-article" @default.
• W2980367074 hasAuthorship W2980367074A5003112344 @default.
• W2980367074 hasAuthorship W2980367074A5012817292 @default.
• W2980367074 hasAuthorship W2980367074A5018041284 @default.
• W2980367074 hasAuthorship W2980367074A5026305547 @default.
• W2980367074 hasAuthorship W2980367074A5032500671 @default.
• W2980367074 hasAuthorship W2980367074A5032986788 @default.
• W2980367074 hasAuthorship W2980367074A5049411008 @default.
• W2980367074 hasAuthorship W2980367074A5050410187 @default.
• W2980367074 hasAuthorship W2980367074A5053375903 @default.
• W2980367074 hasAuthorship W2980367074A5055256446 @default.
• W2980367074 hasAuthorship W2980367074A5057988422 @default.
• W2980367074 hasAuthorship W2980367074A5062691878 @default.
• W2980367074 hasAuthorship W2980367074A5063225225 @default.
• W2980367074 hasAuthorship W2980367074A5063732312 @default.
• W2980367074 hasAuthorship W2980367074A5067354051 @default.
• W2980367074 hasAuthorship W2980367074A5072383371 @default.
• W2980367074 hasAuthorship W2980367074A5086664554 @default.
• W2980367074 hasBestOaLocation W29803670741 @default.
• W2980367074 hasConcept C105795698 @default.
• W2980367074 hasConcept C118552586 @default.
• W2980367074 hasConcept C126322002 @default.
• W2980367074 hasConcept C144024400 @default.
• W2980367074 hasConcept C149923435 @default.
• W2980367074 hasConcept C15744967 @default.
• W2980367074 hasConcept C169900460 @default.
• W2980367074 hasConcept C207103383 @default.
• W2980367074 hasConcept C2779134260 @default.
• W2980367074 hasConcept C2779483572 @default.
• W2980367074 hasConcept C2984863031 @default.
• W2980367074 hasConcept C33923547 @default.
• W2980367074 hasConcept C44249647 @default.
• W2980367074 hasConcept C67739388 @default.
• W2980367074 hasConcept C71104824 @default.
• W2980367074 hasConcept C71924100 @default.
• W2980367074 hasConcept C74909509 @default.
• W2980367074 hasConcept C77350462 @default.
• W2980367074 hasConcept C99454951 @default.
• W2980367074 hasConceptScore W2980367074C105795698 @default.
• W2980367074 hasConceptScore W2980367074C118552586 @default.
• W2980367074 hasConceptScore W2980367074C126322002 @default.
• W2980367074 hasConceptScore W2980367074C144024400 @default.
• W2980367074 hasConceptScore W2980367074C149923435 @default.
• W2980367074 hasConceptScore W2980367074C15744967 @default.
• W2980367074 hasConceptScore W2980367074C169900460 @default.
• W2980367074 hasConceptScore W2980367074C207103383 @default.
• W2980367074 hasConceptScore W2980367074C2779134260 @default.
• W2980367074 hasConceptScore W2980367074C2779483572 @default.
• W2980367074 hasConceptScore W2980367074C2984863031 @default.
• W2980367074 hasConceptScore W2980367074C33923547 @default.
• W2980367074 hasConceptScore W2980367074C44249647 @default.
• W2980367074 hasConceptScore W2980367074C67739388 @default.
• W2980367074 hasConceptScore W2980367074C71104824 @default.
• W2980367074 hasConceptScore W2980367074C71924100 @default.
• W2980367074 hasConceptScore W2980367074C74909509 @default.
• W2980367074 hasConceptScore W2980367074C77350462 @default.
• W2980367074 hasConceptScore W2980367074C99454951 @default.
• W2980367074 hasIssue "7S_Part_16" @default.
• W2980367074 hasLocation W29803670741 @default.
• W2980367074 hasOpenAccess W2980367074 @default.
• W2980367074 hasPrimaryLocation W29803670741 @default.
• W2980367074 hasRelatedWork W182016951 @default.
• W2980367074 hasRelatedWork W2059615097 @default.
• W2980367074 hasRelatedWork W2077992747 @default.
• W2980367074 hasRelatedWork W2172455872 @default.
• W2980367074 hasRelatedWork W2324673403 @default.
• W2980367074 hasRelatedWork W2346048686 @default.
• W2980367074 hasRelatedWork W2561267217 @default.
• W2980367074 hasRelatedWork W2969546739 @default.
• W2980367074 hasRelatedWork W4385271147 @default.
• W2980367074 hasRelatedWork W2741376937 @default.
• W2980367074 hasVolume "15" @default.
• W2980367074 isParatext "false" @default.

• next