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- W2980367932 abstract "More than half of all brain metastases show infiltrating rather than displacing growth at the macro‐metastasis/organ parenchyma interface (MMPI), a finding associated with shorter survival. The lymphoid enhancer‐binding factor‐1 (LEF1) is an epithelial‐mesenchymal transition (EMT) transcription factor that is commonly overexpressed in brain‐colonizing cancer cells. Here, we overexpressed LEF1 in an in vivo breast cancer brain colonization model. It shortened survival, albeit without engaging EMT at the MMPI. By differential proteome analysis, we identified a novel function of LEF1 as a regulator of the glutathione (GSH) system, the principal cellular redox buffer. LEF1 overexpression also conferred resistance against therapeutic GSH depletion during brain colonization and improved management of intracellular ROS. We conclude that besides EMT, LEF1 facilitates metastasis by improving the antioxidative capacity of epithelial breast cancer cells, in particular during colonization of the brain parenchyma." @default.
- W2980367932 created "2019-10-25" @default.
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- W2980367932 date "2019-11-11" @default.
- W2980367932 modified "2023-09-26" @default.
- W2980367932 title "LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer" @default.
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- W2980367932 doi "https://doi.org/10.1002/ijc.32742" @default.
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- W2980367932 hasPublicationYear "2019" @default.
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