FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980373684> ?p ?o ?g. }

• W2980373684 endingPage "7863" @default.
• W2980373684 startingPage "7853" @default.
• W2980373684 abstract "BACKGROUND Laryngeal cancer is one of the most common malignant tumors of the head and neck. Natural compounds in traditional Chinese medicine provide many valuable potential compounds for tumor chemotherapy. Esculetin, a coumarin derivative from several herbs, inhibits proliferation of many types of cancer cells, but its anticancer effect in laryngeal cancer is still not clear. MATERIAL AND METHODS We performed in vitro proliferation assay, invasion assay, and migration assay to assess the effect of esculetin against LC, and in vivo nude mouse xenograft animal model was used as well. Flow cytometry was conducted to analyze the effect of esculetin on cell cycle of LC cells, and Western blot analysis was used to assess the effect esculetin on the JAK-STAT signaling pathway. RESULTS Esculetin remarkably inhibits proliferation, migration, and invasion of LC cells, and reduces in vivo xenograft tumor growth and tumor weight in a dose-dependent manner. Our molecular mechanism study demonstrated that esculetin significantly inhibits STAT3 phosphorylation and blocks translocation of STAT3 into the nucleus, and esculetin also blocks the cell cycle in G1/S phase. CONCLUSIONS In a summary, by inhibiting the STAT3 activation, esculetin shows potential anticancer effects against the laryngeal cancer." @default.
• W2980373684 created "2019-10-25" @default.
• W2980373684 creator A5000801878 @default.
• W2980373684 creator A5008644202 @default.
• W2980373684 creator A5022727895 @default.
• W2980373684 date "2019-10-20" @default.
• W2980373684 modified "2023-10-16" @default.
• W2980373684 title "Esculetin Inhibits Proliferation, Invasion, and Migration of Laryngeal Cancer In Vitro and In Vivo by Inhibiting Janus Kinas (JAK)-Signal Transducer and Activator of Transcription-3 (STAT3) Activation" @default.
• W2980373684 cites W1487876821 @default.
• W2980373684 cites W1550784771 @default.
• W2980373684 cites W1751920243 @default.
• W2980373684 cites W1786592402 @default.
• W2980373684 cites W1832569329 @default.
• W2980373684 cites W1857236668 @default.
• W2980373684 cites W1967237104 @default.
• W2980373684 cites W1983402038 @default.
• W2980373684 cites W1998122509 @default.
• W2980373684 cites W2024274851 @default.
• W2980373684 cites W2025540625 @default.
• W2980373684 cites W2029626852 @default.
• W2980373684 cites W2034210115 @default.
• W2980373684 cites W2057609551 @default.
• W2980373684 cites W2078011082 @default.
• W2980373684 cites W2113231588 @default.
• W2980373684 cites W2145348778 @default.
• W2980373684 cites W2158104043 @default.
• W2980373684 cites W2168457230 @default.
• W2980373684 cites W2177851140 @default.
• W2980373684 cites W2278002112 @default.
• W2980373684 cites W2318269950 @default.
• W2980373684 cites W2346576155 @default.
• W2980373684 cites W2471418100 @default.
• W2980373684 cites W251101325 @default.
• W2980373684 cites W2518545475 @default.
• W2980373684 cites W2557888310 @default.
• W2980373684 cites W2572959384 @default.
• W2980373684 cites W2583708031 @default.
• W2980373684 cites W2591819610 @default.
• W2980373684 cites W2592397452 @default.
• W2980373684 cites W2593109836 @default.
• W2980373684 cites W2627077433 @default.
• W2980373684 cites W2743896081 @default.
• W2980373684 cites W2745712403 @default.
• W2980373684 cites W2786346836 @default.
• W2980373684 cites W2790240293 @default.
• W2980373684 cites W2795798410 @default.
• W2980373684 cites W281569570 @default.
• W2980373684 cites W4211144854 @default.
• W2980373684 doi "https://doi.org/10.12659/msm.916246" @default.
• W2980373684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6820344" @default.
• W2980373684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31630150" @default.
• W2980373684 hasPublicationYear "2019" @default.
• W2980373684 type Work @default.
• W2980373684 sameAs 2980373684 @default.
• W2980373684 citedByCount "19" @default.
• W2980373684 countsByYear W29803736842020 @default.
• W2980373684 countsByYear W29803736842021 @default.
• W2980373684 countsByYear W29803736842022 @default.
• W2980373684 countsByYear W29803736842023 @default.
• W2980373684 crossrefType "journal-article" @default.
• W2980373684 hasAuthorship W2980373684A5000801878 @default.
• W2980373684 hasAuthorship W2980373684A5008644202 @default.
• W2980373684 hasAuthorship W2980373684A5022727895 @default.
• W2980373684 hasBestOaLocation W29803736842 @default.
• W2980373684 hasConcept C112392421 @default.
• W2980373684 hasConcept C150903083 @default.
• W2980373684 hasConcept C171958077 @default.
• W2980373684 hasConcept C185592680 @default.
• W2980373684 hasConcept C190283241 @default.
• W2980373684 hasConcept C202751555 @default.
• W2980373684 hasConcept C207001950 @default.
• W2980373684 hasConcept C2778277574 @default.
• W2980373684 hasConcept C2778923194 @default.
• W2980373684 hasConcept C2780783641 @default.
• W2980373684 hasConcept C29537977 @default.
• W2980373684 hasConcept C502942594 @default.
• W2980373684 hasConcept C55493867 @default.
• W2980373684 hasConcept C62112901 @default.
• W2980373684 hasConcept C62478195 @default.
• W2980373684 hasConcept C86803240 @default.
• W2980373684 hasConcept C98274493 @default.
• W2980373684 hasConceptScore W2980373684C112392421 @default.
• W2980373684 hasConceptScore W2980373684C150903083 @default.
• W2980373684 hasConceptScore W2980373684C171958077 @default.
• W2980373684 hasConceptScore W2980373684C185592680 @default.
• W2980373684 hasConceptScore W2980373684C190283241 @default.
• W2980373684 hasConceptScore W2980373684C202751555 @default.
• W2980373684 hasConceptScore W2980373684C207001950 @default.
• W2980373684 hasConceptScore W2980373684C2778277574 @default.
• W2980373684 hasConceptScore W2980373684C2778923194 @default.
• W2980373684 hasConceptScore W2980373684C2780783641 @default.
• W2980373684 hasConceptScore W2980373684C29537977 @default.
• W2980373684 hasConceptScore W2980373684C502942594 @default.
• W2980373684 hasConceptScore W2980373684C55493867 @default.
• W2980373684 hasConceptScore W2980373684C62112901 @default.
• W2980373684 hasConceptScore W2980373684C62478195 @default.
• W2980373684 hasConceptScore W2980373684C86803240 @default.
• W2980373684 hasConceptScore W2980373684C98274493 @default.

• next