FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980381024> ?p ?o ?g. }

• W2980381024 abstract "Abstract Background Mutators are common in bacterial populations, both in natural isolates and in the lab. The fate of these lineages, which mutation rate is increased up to 100 ×, has long been studied using population genetics models, showing that they can spread in a population following an environmental change. However in stable conditions, they suffer from the increased mutational load, hence being overcome by non-mutators. However, these results don’t take into account the fact that an elevated mutation rate can impact the genetic structure, hence changing the sensitivity of the population to mutations. Here we used Aevol, an in silico experimental evolution platform in which genomic structures are free to evolve, in order to study the fate of mutator populations evolving for a long time in constant conditions. Results Starting from wild-types that were pre-evolved for 300,000 generations, we let 100 mutator populations (point mutation rate ×100) evolve for 100,000 further generations in constant conditions. As expected all populations initially undergo a fitness loss. However, after that the mutator populations started to recover. Most populations ultimately recovered their ancestors fitness, and a significant fraction became even fitter than the non-mutator control clones that evolved in parallel. By analyzing the genomes of the mutators, we show that the fitness recovery is due to two mechanisms: i. an increase in robustness through compaction of the coding part of the mutator genomes, ii. an increase of the selection coefficient that decreases the mean-fitness of the population. Strikingly the latter is due to the accumulation of non-coding sequences in the mutators genomes. Conclusion Our results show that the mutational burden that is classically thought to be associated with mutator phenotype is escapable. On the long run mutators adapted their genomes and reshaped the distribution of mutation effects. Therewith the lineage is able to recover fitness even though the population still suffers the elevated mutation rate. Overall these results change our view of mutator dynamics: by being able to reduce the deleterious effect of the elevated mutation rate, mutator populations may be able to last for a very long time; A situation commonly observed in nature." @default.
• W2980381024 created "2019-10-25" @default.
• W2980381024 creator A5027948774 @default.
• W2980381024 creator A5041639459 @default.
• W2980381024 creator A5060013591 @default.
• W2980381024 date "2019-10-18" @default.
• W2980381024 modified "2023-10-10" @default.
• W2980381024 title "Adapting the engine to the fuel: mutator populations can reduce the mutational load by reorganizing their genome structure" @default.
• W2980381024 cites W104710838 @default.
• W2980381024 cites W1566245339 @default.
• W2980381024 cites W1599229742 @default.
• W2980381024 cites W1842944877 @default.
• W2980381024 cites W1971399377 @default.
• W2980381024 cites W1973081915 @default.
• W2980381024 cites W1977388783 @default.
• W2980381024 cites W1977940795 @default.
• W2980381024 cites W1983153145 @default.
• W2980381024 cites W1990585969 @default.
• W2980381024 cites W2001403617 @default.
• W2980381024 cites W2003916369 @default.
• W2980381024 cites W2008144158 @default.
• W2980381024 cites W2016687536 @default.
• W2980381024 cites W2031581341 @default.
• W2980381024 cites W2035525755 @default.
• W2980381024 cites W2046200816 @default.
• W2980381024 cites W2051116946 @default.
• W2980381024 cites W2055238593 @default.
• W2980381024 cites W2056254121 @default.
• W2980381024 cites W2081567528 @default.
• W2980381024 cites W2086561953 @default.
• W2980381024 cites W2087601214 @default.
• W2980381024 cites W2090853729 @default.
• W2980381024 cites W2102306849 @default.
• W2980381024 cites W2112239989 @default.
• W2980381024 cites W2113422929 @default.
• W2980381024 cites W2116561779 @default.
• W2980381024 cites W2120838291 @default.
• W2980381024 cites W2134153749 @default.
• W2980381024 cites W2135721494 @default.
• W2980381024 cites W2145371963 @default.
• W2980381024 cites W2150452220 @default.
• W2980381024 cites W2151538795 @default.
• W2980381024 cites W2157550743 @default.
• W2980381024 cites W2162570093 @default.
• W2980381024 cites W2163110946 @default.
• W2980381024 cites W2164086560 @default.
• W2980381024 cites W2169720246 @default.
• W2980381024 cites W2171950816 @default.
• W2980381024 cites W2205740488 @default.
• W2980381024 cites W2247230954 @default.
• W2980381024 cites W2263152369 @default.
• W2980381024 cites W2265991105 @default.
• W2980381024 cites W2490493873 @default.
• W2980381024 cites W2593111110 @default.
• W2980381024 cites W2593447578 @default.
• W2980381024 cites W2597039455 @default.
• W2980381024 cites W2603561009 @default.
• W2980381024 cites W2605826472 @default.
• W2980381024 cites W2762187001 @default.
• W2980381024 cites W2763541344 @default.
• W2980381024 cites W2797670317 @default.
• W2980381024 cites W2963220257 @default.
• W2980381024 cites W2968897248 @default.
• W2980381024 doi "https://doi.org/10.1186/s12862-019-1507-z" @default.
• W2980381024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6800497" @default.
• W2980381024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31627727" @default.
• W2980381024 hasPublicationYear "2019" @default.
• W2980381024 type Work @default.
• W2980381024 sameAs 2980381024 @default.
• W2980381024 citedByCount "5" @default.
• W2980381024 countsByYear W29803810242021 @default.
• W2980381024 countsByYear W29803810242022 @default.
• W2980381024 countsByYear W29803810242023 @default.
• W2980381024 crossrefType "journal-article" @default.
• W2980381024 hasAuthorship W2980381024A5027948774 @default.
• W2980381024 hasAuthorship W2980381024A5041639459 @default.
• W2980381024 hasAuthorship W2980381024A5060013591 @default.
• W2980381024 hasBestOaLocation W29803810241 @default.
• W2980381024 hasConcept C104317684 @default.
• W2980381024 hasConcept C141231307 @default.
• W2980381024 hasConcept C144024400 @default.
• W2980381024 hasConcept C149923435 @default.
• W2980381024 hasConcept C176147130 @default.
• W2980381024 hasConcept C24218269 @default.
• W2980381024 hasConcept C2777782036 @default.
• W2980381024 hasConcept C2908647359 @default.
• W2980381024 hasConcept C2910240311 @default.
• W2980381024 hasConcept C2910387474 @default.
• W2980381024 hasConcept C501734568 @default.
• W2980381024 hasConcept C54355233 @default.
• W2980381024 hasConcept C63479239 @default.
• W2980381024 hasConcept C68873052 @default.
• W2980381024 hasConcept C75268714 @default.
• W2980381024 hasConcept C78458016 @default.
• W2980381024 hasConcept C80990810 @default.
• W2980381024 hasConcept C86803240 @default.
• W2980381024 hasConcept C87590526 @default.
• W2980381024 hasConcept C98638677 @default.
• W2980381024 hasConceptScore W2980381024C104317684 @default.
• W2980381024 hasConceptScore W2980381024C141231307 @default.

• next