Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980397112> ?p ?o ?g. }
- W2980397112 abstract "Ghrelin is an endogenous peptide hormone mainly produced in stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin provides it with potential contributions to many aspects of cancer development and progression. Accordingly, large body of evidence has emerged about attributions of ghrelin to many types of cancer in scales of cell-line, animal, and human studies. However, existing data are controversial. This controversy occurs in two main domains: one is the controversial results in local effects of ghrelin on different types of human cancer cell-lines; the second is the apparent controversy in results of in-vitro and clinical studies that investigated ghrelin attributions to one type of cancer. These inconsistencies have hampered the indications to consider ghrelin as a potential tumor biomarker or therapeutic agent in cancer patients. Previous studies have reviewed different parts of current literature about ghrelin-cancer relationship. Although they have spotted these controversial results in various ways, no specific recommendations have been given to address it. In this study, we comprehensively reviewed in-vitro, in-vivo, and clinical studies and attempted to use following approaches to unravel inconsistencies detected: a) to distinguish local and systemic effects of ghrelin in interpreting its summary clinical role in case of each cancer; b) scrutinizing factors that regulate local effects of ghrelin and could justify different effects of ghrelin on different cancer cell-lines. These approaches could have notable implications for future in-vitro and clinical studies." @default.
- W2980397112 created "2019-10-25" @default.
- W2980397112 creator A5004393280 @default.
- W2980397112 creator A5055505514 @default.
- W2980397112 creator A5060195266 @default.
- W2980397112 creator A5078303159 @default.
- W2980397112 creator A5082264539 @default.
- W2980397112 creator A5084224341 @default.
- W2980397112 date "2019-10-16" @default.
- W2980397112 modified "2023-10-16" @default.
- W2980397112 title "Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy" @default.
- W2980397112 cites W1479745892 @default.
- W2980397112 cites W1488497469 @default.
- W2980397112 cites W1496541440 @default.
- W2980397112 cites W1527872053 @default.
- W2980397112 cites W155664710 @default.
- W2980397112 cites W1764209305 @default.
- W2980397112 cites W1794595911 @default.
- W2980397112 cites W1896432851 @default.
- W2980397112 cites W1911222162 @default.
- W2980397112 cites W1957567082 @default.
- W2980397112 cites W1964081706 @default.
- W2980397112 cites W1966149402 @default.
- W2980397112 cites W1966406941 @default.
- W2980397112 cites W1971585714 @default.
- W2980397112 cites W1971922621 @default.
- W2980397112 cites W1973533356 @default.
- W2980397112 cites W1973960035 @default.
- W2980397112 cites W1976324762 @default.
- W2980397112 cites W1976521535 @default.
- W2980397112 cites W1980151037 @default.
- W2980397112 cites W1983232559 @default.
- W2980397112 cites W1987235632 @default.
- W2980397112 cites W2002128555 @default.
- W2980397112 cites W2008259041 @default.
- W2980397112 cites W2008646871 @default.
- W2980397112 cites W2011325404 @default.
- W2980397112 cites W2014159666 @default.
- W2980397112 cites W2014213263 @default.
- W2980397112 cites W2016047217 @default.
- W2980397112 cites W2019140319 @default.
- W2980397112 cites W2024779930 @default.
- W2980397112 cites W2027406160 @default.
- W2980397112 cites W2027612204 @default.
- W2980397112 cites W2027813981 @default.
- W2980397112 cites W2030037892 @default.
- W2980397112 cites W2033519337 @default.
- W2980397112 cites W2033683767 @default.
- W2980397112 cites W2040447977 @default.
- W2980397112 cites W2041503780 @default.
- W2980397112 cites W2042561254 @default.
- W2980397112 cites W2049364897 @default.
- W2980397112 cites W2058620134 @default.
- W2980397112 cites W2063942882 @default.
- W2980397112 cites W2064270643 @default.
- W2980397112 cites W2065021840 @default.
- W2980397112 cites W2065825748 @default.
- W2980397112 cites W2069204226 @default.
- W2980397112 cites W2069231788 @default.
- W2980397112 cites W2069368135 @default.
- W2980397112 cites W2069867624 @default.
- W2980397112 cites W2070861133 @default.
- W2980397112 cites W2072441425 @default.
- W2980397112 cites W2072911841 @default.
- W2980397112 cites W2073295417 @default.
- W2980397112 cites W2074601711 @default.
- W2980397112 cites W2077387520 @default.
- W2980397112 cites W2080426718 @default.
- W2980397112 cites W2085284312 @default.
- W2980397112 cites W2088174309 @default.
- W2980397112 cites W2089153751 @default.
- W2980397112 cites W2096276013 @default.
- W2980397112 cites W2097743939 @default.
- W2980397112 cites W2097997433 @default.
- W2980397112 cites W2101611974 @default.
- W2980397112 cites W2102144390 @default.
- W2980397112 cites W2103010974 @default.
- W2980397112 cites W2106244076 @default.
- W2980397112 cites W2107254624 @default.
- W2980397112 cites W2108836941 @default.
- W2980397112 cites W2108901938 @default.
- W2980397112 cites W2111750192 @default.
- W2980397112 cites W2112777656 @default.
- W2980397112 cites W2118177871 @default.
- W2980397112 cites W2119914128 @default.
- W2980397112 cites W2120152701 @default.
- W2980397112 cites W2121445703 @default.
- W2980397112 cites W2121730871 @default.
- W2980397112 cites W2122240215 @default.
- W2980397112 cites W2122951432 @default.
- W2980397112 cites W2129261404 @default.
- W2980397112 cites W2130990593 @default.
- W2980397112 cites W2131979270 @default.
- W2980397112 cites W2134824624 @default.
- W2980397112 cites W2137560164 @default.
- W2980397112 cites W2139979797 @default.
- W2980397112 cites W2140937639 @default.
- W2980397112 cites W2146099611 @default.
- W2980397112 cites W2150380049 @default.
- W2980397112 cites W2152012721 @default.