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- W2980409898 abstract "Disruption in Default Mode Network (DMN) functional connectivity (FC) is commonly found in Alzheimer's Disease (AD), but studies in MCI have showed conflicting results (normal, hyper or hypoconnectivity) and one of the possible reasons may be the difference regarding AD pathophysiology status in MCI subjects. We compared DMN FC in MCI subjects considering the AT(N) classification and divided subjects in suspected non-Alzheimer's pathophysiology (SNAP), AD continuum (A+) and normal AD biomarkers (N). We recruited 106 volunteers (74 MCI and 32 controls). We classified subgroups based on CSF amyloid-β, total tau and phosphorylated tau results. MCI with altered Aβ were considered A+ (n=40); with t-tau or/and p-tau alterations with normal Aβ were considered SNAP (21) and individuals with normal biomarkers a were considered N (13). All subjects underwent MRI in a 3T scanner. To first identify the DMN, we placed a seed in the posterior cingulate cortex of 50 control subjects generating one spatial map for each one. The resultant DMN mask, which was an average of the 32 maps of controls, was subdivided in 8 non-contiguous regions (PCC, medial frontal, right and left temporal, parietal and hippocampus). Connectivity of these regions were obtained. A multivariate analysis of covariance were performed, using age as covariates. We found significant differences (p<0,05, corrected) in Right-hippocampus, Right-temporal and PCC between controls and all AT(N) subcategories. Right parietal was different only in SNAP and A+. An inspection of the means scores shown lower connectivity in Right subparts of DMN in MCI and higher connectivity in PCC compared to controls. We found a lower connectivity in right subparts of DMN and a higher in PCC in MCI individuals compared to controls, independent of AT(N) status. These findings were not expected and could imply that the different pathologic processes in MCI has similar outcomes on connectivity. Interestingly, we found patterns of hypo and hyperconnectivity in DMN of all MCI subgroups and, in addition, a right-left asymmetry in the studied DMN subparts." @default.
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- W2980409898 date "2019-07-01" @default.
- W2980409898 modified "2023-10-01" @default.
- W2980409898 title "P3-377: DEFAULT MODE NETWORK CONNECTIVITY IN MCI SUBGROUPS ACCORDING TO AT(N) CLASSIFICATION COMPARED TO HEALTHY AGING" @default.
- W2980409898 doi "https://doi.org/10.1016/j.jalz.2019.06.3410" @default.
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