FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980420293> ?p ?o ?g. }

• W2980420293 endingPage "A466" @default.
• W2980420293 startingPage "A465" @default.
• W2980420293 abstract "SESSION TITLE: Monday Electronic Posters 5 SESSION TYPE: Original Inv Poster Discussion PRESENTED ON: 10/21/2019 02:30 PM - 03:15 PM PURPOSE: The Tobacco Heating System (THS) 2.2 is a novel product that electrically heats tobacco at temperatures significantly lower (< 350°C) than those generated when burning cigarettes (CC), producing substantially lower levels of harmful and potentially harmful constituents, with a mean decrease of 90%. A randomized, two-arm parallel group, multicenter exposure study conducted in the U.S. (NCT02396381) demonstrated statistically significant changes in five of eight biomarkers of effect (BoEff) at six months among adults switching to THS compared with those who continued smoking, meeting the primary study objective, with all BoEff moving in the direction of smoking cessation (SC). The study was extended by an additional six months (NCT02649556), and these favorable changes were maintained over 12 months. METHODS: This analysis was designed to explore the effect of switching to THS (n=17) compared with continued smoking (n=28) in a subgroup of subjects from the two aforementioned exposure studies with baseline spirometry indicating mild to moderate chronic obstructive pulmonary disease (COPD) according to GOLD 2018 criteria. Results from a subset of subjects (n=18) with mild COPD from a one-year continuous smoking abstinence study (NCT02432729) were used as a reference. The analysis was also conducted on a broadened subgroup including subjects with obstruction defined by forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ≤ 0.75, based on the Lung Health Study’s review1 of mild to moderate COPD that defined obstruction with the precedent American Thoracic Society guidelines. The main respiratory and cardiovascular endpoints were white blood cell count (WBC), soluble intercellular adhesion molecule 1 (sICAM-1), and 8-epi-prostaglandin F2α (8-epi-PGF2α). RESULTS: After 12 months of follow up, favorable shifts in the direction of changes observed in SC were observed for most of the BoEff in COPD subjects following predominant (>=70%) THS use. The magnitude of these shifts was more pronounced than those observed in the general population of exposure studies, where a majority of healthy subjects were enrolled, with a THS-CC difference of 72 mL in FEV1 among COPD subjects and a reduction for THS of 1.95 GI/L in WBC, 6.8% in sICAM-1, and 28% in 8-epi-PGF2α compared with CC. CONCLUSIONS: he results of this preliminary analysis are coherent with the main study findings, with marked changes observed among subjects with COPD. CLINICAL IMPLICATIONS: The results of this preliminary analysis suggest reduced harm potential for THS compared with smoking in mild to moderate COPD subjects. DISCLOSURES: Employee relationship with Philip Morris Products S.A. Please note: >$100000 Added 01/29/2019 by S. Michael Ansari, source=Web Response, value=Salary No relevant relationships by Ashraf Elamin, source=Web Response Employee relationship with Philip Morris Products SA Please note: >$100000 Added 03/15/2019 by Loyse Felber Medlin, source=Web Response, value=Salary No relevant relationships by Christelle Haziza, source=Web Response My spouse/partner as a Employee relationship with Medtronic Please note: >$100000 Added 03/15/2019 by Nicola Lama, source=Web Response, value=Salary Employee relationship with PMP SA Please note: >$100000 Added 03/15/2019 by Nicola Lama, source=Web Response, value=Salary My spouse/partner as a Stock holder relationship with Medtronic Please note: $20001 - $100000 Added 03/15/2019 by Nicola Lama, source=Web Response, value=stocks No relevant relationships by Francesco Sergio, source=Web Response" @default.
• W2980420293 created "2019-10-25" @default.
• W2980420293 creator A5013328989 @default.
• W2980420293 creator A5023917646 @default.
• W2980420293 creator A5032393679 @default.
• W2980420293 creator A5084713895 @default.
• W2980420293 creator A5087638288 @default.
• W2980420293 creator A5091599756 @default.
• W2980420293 date "2019-10-01" @default.
• W2980420293 modified "2023-09-27" @default.
• W2980420293 title "TOBACCO HEATING SYSTEM 2.2 IN MILD TO MODERATE COPD SUBJECTS: AN EXPLORATORY ANALYSIS" @default.
• W2980420293 doi "https://doi.org/10.1016/j.chest.2019.08.485" @default.
• W2980420293 hasPublicationYear "2019" @default.
• W2980420293 type Work @default.
• W2980420293 sameAs 2980420293 @default.
• W2980420293 citedByCount "1" @default.
• W2980420293 countsByYear W29804202932021 @default.
• W2980420293 crossrefType "journal-article" @default.
• W2980420293 hasAuthorship W2980420293A5013328989 @default.
• W2980420293 hasAuthorship W2980420293A5023917646 @default.
• W2980420293 hasAuthorship W2980420293A5032393679 @default.
• W2980420293 hasAuthorship W2980420293A5084713895 @default.
• W2980420293 hasAuthorship W2980420293A5087638288 @default.
• W2980420293 hasAuthorship W2980420293A5091599756 @default.
• W2980420293 hasConcept C118552586 @default.
• W2980420293 hasConcept C126322002 @default.
• W2980420293 hasConcept C142724271 @default.
• W2980420293 hasConcept C165637977 @default.
• W2980420293 hasConcept C1862650 @default.
• W2980420293 hasConcept C187960798 @default.
• W2980420293 hasConcept C2776042228 @default.
• W2980420293 hasConcept C2776780178 @default.
• W2980420293 hasConcept C2777714996 @default.
• W2980420293 hasConcept C2777843972 @default.
• W2980420293 hasConcept C2780333948 @default.
• W2980420293 hasConcept C2780687700 @default.
• W2980420293 hasConcept C2992779976 @default.
• W2980420293 hasConcept C3018587741 @default.
• W2980420293 hasConcept C44249647 @default.
• W2980420293 hasConcept C55520419 @default.
• W2980420293 hasConcept C71924100 @default.
• W2980420293 hasConceptScore W2980420293C118552586 @default.
• W2980420293 hasConceptScore W2980420293C126322002 @default.
• W2980420293 hasConceptScore W2980420293C142724271 @default.
• W2980420293 hasConceptScore W2980420293C165637977 @default.
• W2980420293 hasConceptScore W2980420293C1862650 @default.
• W2980420293 hasConceptScore W2980420293C187960798 @default.
• W2980420293 hasConceptScore W2980420293C2776042228 @default.
• W2980420293 hasConceptScore W2980420293C2776780178 @default.
• W2980420293 hasConceptScore W2980420293C2777714996 @default.
• W2980420293 hasConceptScore W2980420293C2777843972 @default.
• W2980420293 hasConceptScore W2980420293C2780333948 @default.
• W2980420293 hasConceptScore W2980420293C2780687700 @default.
• W2980420293 hasConceptScore W2980420293C2992779976 @default.
• W2980420293 hasConceptScore W2980420293C3018587741 @default.
• W2980420293 hasConceptScore W2980420293C44249647 @default.
• W2980420293 hasConceptScore W2980420293C55520419 @default.
• W2980420293 hasConceptScore W2980420293C71924100 @default.
• W2980420293 hasIssue "4" @default.
• W2980420293 hasLocation W29804202931 @default.
• W2980420293 hasOpenAccess W2980420293 @default.
• W2980420293 hasPrimaryLocation W29804202931 @default.
• W2980420293 hasRelatedWork W1789955178 @default.
• W2980420293 hasRelatedWork W1978764073 @default.
• W2980420293 hasRelatedWork W1981370845 @default.
• W2980420293 hasRelatedWork W1997708290 @default.
• W2980420293 hasRelatedWork W2005813999 @default.
• W2980420293 hasRelatedWork W2062563256 @default.
• W2980420293 hasRelatedWork W2470095143 @default.
• W2980420293 hasRelatedWork W3082051405 @default.
• W2980420293 hasRelatedWork W3111354819 @default.
• W2980420293 hasRelatedWork W65928832 @default.
• W2980420293 hasVolume "156" @default.
• W2980420293 isParatext "false" @default.
• W2980420293 isRetracted "false" @default.
• W2980420293 magId "2980420293" @default.
• W2980420293 workType "article" @default.