Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980423849> ?p ?o ?g. }
- W2980423849 abstract "It is well established that aberrant WNT expression and signaling is associated with developmental defects, malignant transformation and carcinogenesis. More recently, WNT ligands have emerged as integral components of host responses to infection but their functions in the context of immune responses are incompletely understood. Roles in the modulation of inflammatory cytokine production, host cell intrinsic innate defense mechanisms, as well as the bridging of innate and adaptive immunity have been described. To what degree WNT responses are defined by the nature of the invading pathogen or are specific for subsets of host cells is currently not well understood. Here we provide an overview of the nature of WNT responses during infection with phylogenetically diverse pathogens and highlight functions of WNT ligands in the host defense against infection. Detailed understanding of how the WNT network orchestrates immune cell functions will not only improve our understanding of the fundamental principles underlying complex immune response, but also help identify therapeutic opportunities or potential risks associated with the pharmacological targeting of the WNT network, as currently pursued for novel therapeutics in cancer and bone disorders." @default.
- W2980423849 created "2019-10-25" @default.
- W2980423849 creator A5009195980 @default.
- W2980423849 creator A5072007540 @default.
- W2980423849 creator A5077716691 @default.
- W2980423849 creator A5078043270 @default.
- W2980423849 date "2019-11-08" @default.
- W2980423849 modified "2023-10-18" @default.
- W2980423849 title "Functions of the WNT Signaling Network in Shaping Host Responses to Infection" @default.
- W2980423849 cites W1094579134 @default.
- W2980423849 cites W1510564517 @default.
- W2980423849 cites W1548904081 @default.
- W2980423849 cites W1576159916 @default.
- W2980423849 cites W1584987732 @default.
- W2980423849 cites W1590355453 @default.
- W2980423849 cites W1624381791 @default.
- W2980423849 cites W1653521872 @default.
- W2980423849 cites W1668249239 @default.
- W2980423849 cites W1816691520 @default.
- W2980423849 cites W1839632455 @default.
- W2980423849 cites W1886161212 @default.
- W2980423849 cites W1898335101 @default.
- W2980423849 cites W1939496219 @default.
- W2980423849 cites W1953291717 @default.
- W2980423849 cites W1964804755 @default.
- W2980423849 cites W1964957275 @default.
- W2980423849 cites W1966122707 @default.
- W2980423849 cites W1967073403 @default.
- W2980423849 cites W1970596089 @default.
- W2980423849 cites W1971354029 @default.
- W2980423849 cites W1973734543 @default.
- W2980423849 cites W1974094726 @default.
- W2980423849 cites W1974595623 @default.
- W2980423849 cites W1977047885 @default.
- W2980423849 cites W1980767418 @default.
- W2980423849 cites W1981349080 @default.
- W2980423849 cites W1981775580 @default.
- W2980423849 cites W1982336014 @default.
- W2980423849 cites W1984466107 @default.
- W2980423849 cites W1985916857 @default.
- W2980423849 cites W1986900494 @default.
- W2980423849 cites W1987488836 @default.
- W2980423849 cites W1990066341 @default.
- W2980423849 cites W1991125926 @default.
- W2980423849 cites W1995046740 @default.
- W2980423849 cites W1996649087 @default.
- W2980423849 cites W1999453326 @default.
- W2980423849 cites W2002019400 @default.
- W2980423849 cites W2003362984 @default.
- W2980423849 cites W2006419043 @default.
- W2980423849 cites W2006595571 @default.
- W2980423849 cites W2009295603 @default.
- W2980423849 cites W2012425967 @default.
- W2980423849 cites W2013891209 @default.
- W2980423849 cites W2015929270 @default.
- W2980423849 cites W2017991098 @default.
- W2980423849 cites W2018204780 @default.
- W2980423849 cites W2020120915 @default.
- W2980423849 cites W2025453970 @default.
- W2980423849 cites W2027995647 @default.
- W2980423849 cites W2039594437 @default.
- W2980423849 cites W2044531485 @default.
- W2980423849 cites W2047975322 @default.
- W2980423849 cites W2048127493 @default.
- W2980423849 cites W2048425686 @default.
- W2980423849 cites W2051624291 @default.
- W2980423849 cites W2055456092 @default.
- W2980423849 cites W2056833504 @default.
- W2980423849 cites W2057718072 @default.
- W2980423849 cites W2059143300 @default.
- W2980423849 cites W2060961438 @default.
- W2980423849 cites W2061310876 @default.
- W2980423849 cites W2061460524 @default.
- W2980423849 cites W2067056588 @default.
- W2980423849 cites W2067937471 @default.
- W2980423849 cites W2069264443 @default.
- W2980423849 cites W2071340135 @default.
- W2980423849 cites W2073027692 @default.
- W2980423849 cites W2073880758 @default.
- W2980423849 cites W2077424157 @default.
- W2980423849 cites W2077875665 @default.
- W2980423849 cites W2079038017 @default.
- W2980423849 cites W2081985759 @default.
- W2980423849 cites W2082465173 @default.
- W2980423849 cites W2084345598 @default.
- W2980423849 cites W2086078586 @default.
- W2980423849 cites W2087251699 @default.
- W2980423849 cites W2087959682 @default.
- W2980423849 cites W2090272171 @default.
- W2980423849 cites W2091323534 @default.
- W2980423849 cites W2091341060 @default.
- W2980423849 cites W2092981956 @default.
- W2980423849 cites W2093459616 @default.
- W2980423849 cites W2096165445 @default.
- W2980423849 cites W2100637185 @default.
- W2980423849 cites W2101314557 @default.
- W2980423849 cites W2101889783 @default.
- W2980423849 cites W2102312968 @default.
- W2980423849 cites W2109898427 @default.
- W2980423849 cites W2111778006 @default.