FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980431328> ?p ?o ?g. }

• W2980431328 abstract "Androgens play a key role in the male development. All the physiological processes in the body, including the production of testosterone, have their chronobiological features. Aging is accompanied by a disruption in the regulation of chronobiological processes. With androgen deficiency, these changes occur at any age. In recent years, transdermal forms of testosterone have become very popular in the treatment of this condition.To evaluate the effectiveness and chronobiological features of various regimens of testosterone gel therapy for external use in men with androgen deficiency.The study comprised 90 men aged 45 to 60 years with testosterone deficiency. Patients were randomized into three groups of 30 people each. In group I (control) patients received basic therapy, including exercise, diet, and multivitamins. In group II, patients received basic therapy concurrently with testosterone gel for external use (Androgel) at a daily dose of 5 g (1 sachet). Patients in group III were administered basic therapy in combination with 10 g testosterone (2 sachets). The effectiveness of treatment was assessed at 3 (visit 2) and 6 (visit 3) months. Depending on the results of visit 2, a correction of therapy was carried out, if necessary. During each visit, the patients underwent evaluation, including hematocrit, levels of FSH, LH, prolactin, total testosterone, blood SHBG, waist circumference, and body weight. Patients completed the ICEF-5 questionnaire, the Hamilton scale (HDRS, HARS), and the SF-36 questionnaire. We also tested the patients for the chronobiological status and desynchronosis.During the visit I, the homogeneity of the study population was confirmed. At three months, the patients of groups II and III showed a more pronounced increase in testosterone, a decrease in body weight and waist circumference, as well as an improvement in the psycho-emotional status and quality of life according to the questionnaires. Desynchronosis persisted in 25 (83.3%), 9 (30%), and 4 (13.3%) patients in groups I, II, and III, respectively. Given the findings, the treatment was adjusted. The patients in the groups were divided into subgroups A and B. In subgroups A, patients continued to receive initial therapy, and in subgroups B, the treatment was adjusted. At six months, the level of GT increased to normal values in all subgroups except subgroup IA. The most marked reduction in body weight and waist circumference was noted in subgroups IA, IIA, and IIIB. A significant decrease in the average scores on the HDRS and HARS scales and an improvement in the SF-36 scale were observed in the subgroups IA, IIA, IIIB. Desynchronosis persisted in 3, 2, and one patient in subgroups IB, IIB, and IIIA.The testosterone gel therapy in patients with androgen deficiency can effectively reverse the manifestations of the disease and normalize the chronorhythm. Transdermal testosterone gel at a daily dose of 5 g in the morning can be recommended to alleviate clinical manifestations of the disease and eliminate desynchronosis in this category of patients. In patients with low baseline testosterone levels, it is advisable to administer the drug at a daily dose of 10 g." @default.
• W2980431328 created "2019-10-25" @default.
• W2980431328 creator A5021192830 @default.
• W2980431328 creator A5050480430 @default.
• W2980431328 creator A5055334345 @default.
• W2980431328 date "2018-10-09" @default.
• W2980431328 modified "2023-09-26" @default.
• W2980431328 title "Chronobiological features of different regimens of testosterone gel therapy in men with androgen deficiency" @default.
• W2980431328 doi "https://doi.org/10.18565/urology.2018.4.88-95" @default.
• W2980431328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30761795" @default.
• W2980431328 hasPublicationYear "2018" @default.
• W2980431328 type Work @default.
• W2980431328 sameAs 2980431328 @default.
• W2980431328 citedByCount "0" @default.
• W2980431328 crossrefType "journal-article" @default.
• W2980431328 hasAuthorship W2980431328A5021192830 @default.
• W2980431328 hasAuthorship W2980431328A5050480430 @default.
• W2980431328 hasAuthorship W2980431328A5055334345 @default.
• W2980431328 hasConcept C126322002 @default.
• W2980431328 hasConcept C134018914 @default.
• W2980431328 hasConcept C2777911890 @default.
• W2980431328 hasConcept C2779279991 @default.
• W2980431328 hasConcept C2779665388 @default.
• W2980431328 hasConcept C2908647359 @default.
• W2980431328 hasConcept C42407357 @default.
• W2980431328 hasConcept C71315377 @default.
• W2980431328 hasConcept C71924100 @default.
• W2980431328 hasConcept C99454951 @default.
• W2980431328 hasConceptScore W2980431328C126322002 @default.
• W2980431328 hasConceptScore W2980431328C134018914 @default.
• W2980431328 hasConceptScore W2980431328C2777911890 @default.
• W2980431328 hasConceptScore W2980431328C2779279991 @default.
• W2980431328 hasConceptScore W2980431328C2779665388 @default.
• W2980431328 hasConceptScore W2980431328C2908647359 @default.
• W2980431328 hasConceptScore W2980431328C42407357 @default.
• W2980431328 hasConceptScore W2980431328C71315377 @default.
• W2980431328 hasConceptScore W2980431328C71924100 @default.
• W2980431328 hasConceptScore W2980431328C99454951 @default.
• W2980431328 hasLocation W29804313281 @default.
• W2980431328 hasLocation W29804313282 @default.
• W2980431328 hasOpenAccess W2980431328 @default.
• W2980431328 hasPrimaryLocation W29804313281 @default.
• W2980431328 hasRelatedWork W1979452793 @default.
• W2980431328 hasRelatedWork W1981433740 @default.
• W2980431328 hasRelatedWork W1986311037 @default.
• W2980431328 hasRelatedWork W1986969712 @default.
• W2980431328 hasRelatedWork W2023030003 @default.
• W2980431328 hasRelatedWork W2024718203 @default.
• W2980431328 hasRelatedWork W2030888955 @default.
• W2980431328 hasRelatedWork W2061554880 @default.
• W2980431328 hasRelatedWork W2083564258 @default.
• W2980431328 hasRelatedWork W2908463329 @default.
• W2980431328 isParatext "false" @default.
• W2980431328 isRetracted "false" @default.
• W2980431328 magId "2980431328" @default.
• W2980431328 workType "article" @default.